A5092278116- Fluorine in Organic Chemistry
- Inorganic Fluorides and Related Compounds
- Radical Photochemical Reactions
- Oxidative Organic Chemistry Reactions
- Carbon dioxide utilization in catalysis
- Organic Chemistry Cycloaddition Reactions
- Cyclopropane Reaction Mechanisms
Enamine (Ukraine)
2023-2025
A general method to convert simple exocyclic alkenes (no Ar‐substituents) into saturated F2‐rings has been developed. The reaction involves the IIII‐reagent C6F5I(OAc)2 (F5‐PIDA). efficiently works on mg‐, g‐, and even multigram scale.
A general method to convert simple exocyclic alkenes (no Ar‐substituents) into saturated F2‐rings has been developed. The reaction involves the IIII‐reagent C6F5I(OAc)2 (F5‐PIDA). efficiently works on mg‐, g‐, and even multigram scale.
Incorporating fluorine into aliphatic rings induces significant alterations in molecular conformation, acidity/basicity, and lipophilicity. Current methods for synthesizing fluorinated rings, however, involve manipulating functional groups within pre-existing ring systems. Here, we have developed a novel chemical reaction - gem-difluorinative ring-expansion of methylenecycloalkanes. The involves iodine(III) species, allows the preparation gem-difluorinated macrocyclic, fused, spiro, bridged,...
In 2012, bicyclo[1.1.1]pentanes were demonstrated to be bioisosteres of the phenyl ring. Today, after more than a decade, difficulty in their large-scale preparation is still problem, that often outweighs corresponding derivatives becoming clinical candidates. Here, we report practical general reaction gives on mg- kg-quantities using just light. No additional additives or catalysts are needed. Using this strategy, have prepared >300 functionalized (multi)gram scale. So far, most and...
A general method to convert simple exocyclic alkenes (no Ar-substituents) into saturated F2-rings has been developed. The reaction involves the IIII-reagent C6F5I(OAc)2 (F5-PIDA). efficiently works on a mg-, g-, and even multigram scale.