A5049440137- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Glioma Diagnosis and Treatment
- Galectins and Cancer Biology
- Neuroendocrine Tumor Research Advances
- Histone Deacetylase Inhibitors Research
- Glycosylation and Glycoproteins Research
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Surgical Simulation and Training
- Cancer Mechanisms and Therapy
- Spinal Fractures and Fixation Techniques
- Teratomas and Epidermoid Cysts
- Anatomy and Medical Technology
- Head and Neck Surgical Oncology
- Cancer Research and Treatments
- Acute Ischemic Stroke Management
- Immunotherapy and Immune Responses
- Blood Coagulation and Thrombosis Mechanisms
- Spinal Cord Injury Research
- Child Abuse and Related Trauma
- Pelvic and Acetabular Injuries
- Urologic and reproductive health conditions
- Soft tissue tumor case studies
- Fibroblast Growth Factor Research
Medical University of South Carolina
2014-2025
Neurological Surgery
2023
Cincinnati Children's Hospital Medical Center
2015-2017
Neurosciences Institute
2016
BACKGROUND Myelomeningocele and sagittal craniosynostosis are 2 neurosurgical pathologies with complications such as increased intracranial pressure (ICP) hydrocephalus. While the defects commonly occur independently, their simultaneous occurrence is exceptionally rare. OBSERVATIONS The authors report case of a newborn male diagnosed myelomeningocele craniosynostosis. patient underwent surgical repair days after birth. Wound breakdown ventriculomegaly were observed 13 Surgical wound was...
Fixation at the craniovertebral junction (CVJ) is necessary in a variety of pediatric clinical scenarios. Traditionally an occipital bone to cervical fusion preformed, which requires large amount hardware be placed on occiput child. If patient has previously undergone posterior fossa decompression or time procedure, it can difficult anchor plate bone. The authors propose technique that used when faced with this challenge by using condyle as point fixation for construct. Adult cadaveric and...
Hypophosphatasia (HPP) is a rare inherited disorder of bone metabolism that results in the loss function gene coding for tissue-nonspecific alkaline phosphatase (TNSALP). Patients with HPP have defective mineralization as well craniosynostosis can be seen infantile and childhood forms this disease. Traditionally, has had poor prognosis, few children surviving to exhibit phenotype clinical requires surgical intervention. Here, authors report on new advancements enzyme replacement therapy...
Background: Meningiomas represent ∼30% of primary central nervous system (CNS) tumors. Although advances in surgery and radiotherapy have significantly improved survival, there remains an important subset patients whose tumors more aggressive behavior are refractory to conventional therapy. Recent molecular genetics epigenetics suggest that this may be due the deletion DNA repair tumor suppressor gene, CHEK2, neurofibromatosis Type 2 (NF2) mutation on chromosome 22q12, genetic abnormalities...
Optimal intraoperative visualization has been the cornerstone for successful completion of cranial, spinal, and peripheral nerve neurosurgery. The conventional operating microscope most important advance in neurosurgery since its introduction 1957. However, limitations current binocular include magnification, illumination, short field depth requiring frequent manipulation, confocal view, as well challenging surgeon ergonomics. recent advent digital surgical exoscope provided neurosurgeons...
<h3>Objective:</h3> Investigation novel treatment options for Group 3 and 4 medulloblastoma patients <h3>Background:</h3> medulloblastomas (MB) have a significantly worse prognosis when compared to the sonic hedgehog (SHH) or wingless (WNT) -activated subtypes are also most resistant therapy. Current aggressive radiation/chemotherapy practices though improving survival, potential long-term comorbidities with neurocognitive deficits impacting patients' overall quality of life. A key factor...
Acute ischemic stroke (AIS) in the pediatric population is rare. Furthermore, it common for physicians to take significantly longer diagnosing a posterior circulation child than an adult. There are increasing case reports literature of treating AIS children with intravenous tissue plasminogen activator, intra-arterial thrombolysis, and/or mechanical thrombectomy. We present first treated using direct aspiration pass technique (ADAPT) as means
Acute ischemic stroke (AIS) in the pediatric population is rare. Furthermore, it common for physicians to take significantly longer diagnosing a posterior circulation child than an adult. There are increasing case reports literature of treating AIS children with intravenous tissue plasminogen activator, intra-arterial thrombolysis, and/or mechanical thrombectomy. We present first treated using direct aspiration pass technique (ADAPT) as means
BACKGROUND Traumatic aneurysms are a rare sequela of nonaccidental head trauma in infants. The rate (NAT) the pediatric population is increasing; therefore, traumatic an important consideration evaluation patients with abusive trauma. OBSERVATIONS A 24-day-old infant no significant past medical or birth history presented twitching and poor oral intake for 1 day. patient was found to have bilateral subdural hematomas, multifocal contusions, subarachnoid hemorrhage. NAT work-up remarkable...
Abstract BACKGROUND Human glioblastoma (GBM), especially those exhibiting anti-VEGF resistance, overexpress the carbohydrate-binding protein galectin-1 (Gal-1). To develop novel anti-GBM approaches, we developed Gal-1 targeted CAR-T cells to investigate potential antitumor effect with in vitro and ex vivo slice culture models. METHODS Uniform GBM brain cultures were collected using NICO’s Myriad resection tool their Automated Preservation System (APS), designed obtain fresh tumor samples...