A5056326209- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Molecular Sensors and Ion Detection
- Drug Transport and Resistance Mechanisms
- interferon and immune responses
- Immune Response and Inflammation
- Amino Acid Enzymes and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Trace Elements in Health
- Histone Deacetylase Inhibitors Research
- Advanced MRI Techniques and Applications
- Cancer-related gene regulation
- Redox biology and oxidative stress
- Advanced Neuroimaging Techniques and Applications
- HIV/AIDS drug development and treatment
- Mitochondrial Function and Pathology
- Glioma Diagnosis and Treatment
Brown University
2024
Rhode Island Hospital
2024
CeMM Research Center for Molecular Medicine
2020
Austrian Academy of Sciences
2020
Boston College
2017
With more than 450 members, the solute carrier (SLC) group of proteins represents largest class transporters encoded in human genome. Their several-pass transmembrane domain structure and hydrophobicity contribute to orphan status many SLCs, devoid known cargos or chemical inhibitors. We report that SLC belonging different families subcellular compartments are amenable induced degradation by heterobifunctional ligands. Engineering endogenous alleles via tag (dTAG) technology enabled control...
The mitochondria are dynamic organelles that regulate oxidative metabolism and mediate cellular redox homeostasis. Proteins within the exposed to large fluxes in surrounding environment. In particular, cysteine residues mitochondrial proteins sense respond these changes through modifications of thiol group. These result a loss reactivity, which can be monitored using cysteine-reactive chemical probes quantitative mass spectrometry (MS). Analysis cell lysates treated with enable...
Class IIa histone deacetylases (HDACs) are a family of enzymes with minimal deacetylase activity but can function as multi-protein interaction hubs. Here we demonstrate the expression HDAC7, HDAC member, in glioblastoma tumor tissue from 84 patients, patient-derived glioma stem cells (GSCs) six and pediatric diffuse pontine (DIPG) three patients. HDAC7 binds to Histone H3.3 interacts HIRA on chromatin. Targeted downregulation subtype-specific siRNA inhibits while increasing association DAXX...
Background: The invasion of glioblastoma cells beyond the visible tumor margin depicted by conventional neuroimaging is believed to mediate recurrence and predict poor survival. Radiomic biomarkers that are associated with direction extent infiltration are, however, non-existent. Methods: Patients from a single center newly diagnosed (n = 7) underwent preoperative Q-space magnetic resonance imaging (QSI; 3T, 64 gradient directions, b 1000 s/mm2) between 2018 2019. Tumors were manually...