A5030160875- Frailty in Older Adults
- Cardiac, Anesthesia and Surgical Outcomes
- Nutrition and Health in Aging
- Colorectal Cancer Screening and Detection
- Machine Learning in Healthcare
- Colorectal Cancer Surgical Treatments
- Intestinal and Peritoneal Adhesions
- Global Health and Surgery
- Health, Environment, Cognitive Aging
- Birth, Development, and Health
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Hip and Femur Fractures
- Endometriosis Research and Treatment
- Intestinal Malrotation and Obstruction Disorders
- Nutritional Studies and Diet
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Muscle and Compartmental Disorders
- Geriatric Care and Nursing Homes
- Clostridium difficile and Clostridium perfringens research
- Appendicitis Diagnosis and Management
- Microscopic Colitis
- Gastroesophageal reflux and treatments
University of Otago
2018-2024
Christchurch Hospital
2018-2023
University of Edinburgh
2022
The Royal Melbourne Hospital
2020-2021
Taranaki Base Hospital
2016
Frailty is an important concept in modern healthcare due to its association with adverse outcomes. Its prevalence varies the literature and there a paucity of looking at frailty inpatient setting. significance lies on impact resource utilisation costs.To determine adult population tertiary New Zealand hospital.Eligible patients aged 18 years over were invited participate, assessment was performed using Reported Edmonton Frail Scale. A score 8 or more considered frail. Factors associated...
BACKGROUND: Frailty and sarcopenia are important concepts in surgical practice because of their association with adverse postoperative outcomes. Radiologically assessed psoas muscle mass has been proposed as a surrogate for may be predictive poor OBJECTIVE: This study aimed to determine the between sarcopenia, by cross-sectional area, outcomes patients undergoing colorectal cancer surgery. DESIGN: was retrospective review patient records from 2014 2016. SETTINGS: conducted at single tertiary...
Abstract Background: GPR68 is a proton-sensing GPCR reported to play role promoting tumor aggressiveness and immune-evasion, as well in inflammatory disease. Most data supporting these findings come from genetic studies, disclosed small molecule compounds targeting are scarce. Nevertheless, two distinct chemical entities have recently been inhibitors. They used define vitro mechanisms by which may affect disease biology. One of these, FT011, has completed Phase 2 trial for scleroderma...
Abstract Background: Aggressive tumors are often characterized by a fibrotic and acidic microenvironment. These features associated with immune dysfunction, reduced survival, impaired efficacy of chemo- immunotherapies. One axis mediating these functions acts via GPR68, proton-sensing receptor thought to be selectively enriched in cancer fibroblasts (CAFs). In mouse models, GPR68 deletion is tumor burden increased overall potentially reversing immunosuppressive effects the environment. To...
Abstract Background An increasing number of elderly patients are presenting for elective surgery. Pre‐operative risk assessment in this population is inexact due to the complex interplay between age, comorbidity and functional status. Frailty may provide a surrogate measure patient's physiological reserve aid operative decision‐making. The aim study determine association pre‐operative frailty, as assessed using Edmonton Frail Scale, post‐operative outcomes undergoing colorectal cancer...
Multiple tools exist estimating perioperative risk. With an ageing surgical demographic, frailty is becoming increasingly important concept in medicine due to its association with adverse post-operative outcomes. Reduced physical activity a hallmark of frailty, and we postulate that low pre-operative step count may be objective measure frailty. This study aimed determine the between outcomes patients undergoing elective colorectal cancer surgery. A prospective analysis 85 older major surgery...
A diverting ileostomy is typically performed to divert intestinal contents in high-risk colorectal anastomoses. Ileostomy closure associated with high rates of postoperative Clostridium difficile infection (CDI). Risk factors for the development CDI are unclear; however, a correlation has been observed delayed closure. This study aimed assess odds developing patients who had delay reversal ileostomy, compared those no delay.A retrospective cohort was conducted undergoing between 2010 and...
Background Endoscopic retrograde cholangiopancreatography ( ERCP ) is an essential tool in the management of pancreaticobiliary pathology. It technically demanding and has potential to cause significant morbidity mortality. Several trials have identified small centres lower hospital volume as risk factors for success rates higher complication rates. Taranaki Base Hospital TBH a provincial with catchment 100 000, providing its population on‐site service. Transporting patients nearest tertiary...
Abstract Background Sessile serrated lesions (SSL) account for up to 30% of colorectal carcinoma pathogenesis. With multiple classification changes and improvements in colonoscopy equipment technique, historical reporting may have underestimated the true incidence SSLs. This study aimed determine SSLs patients undergoing colonoscopic investigation Canterbury, New Zealand over a 1‐year period describe their clinical pathological characteristics. Methods Electronic records were searched...
Abstract Background Aotearoa New Zealand (AoNZ) guidelines suggest surveillance colonoscopy should be carefully considered after age 75. The authors noted a cluster of patients presenting in their 8th and 9th decade life with new colorectal cancer (CRC) having previously been declined colonoscopy. Methods A 7‐year retrospective analysis was performed who underwent aged between 71 75 years the period 2006 2012. Kaplan–Meier graphs were created survival measured from time index Log rank tests...