A5027090470- Computational Drug Discovery Methods
- MicroRNA in disease regulation
- Renal Transplantation Outcomes and Treatments
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Bioactive Compounds and Antitumor Agents
- Child Nutrition and Water Access
- SARS-CoV-2 and COVID-19 Research
- Peptidase Inhibition and Analysis
- Algal biology and biofuel production
- RNA Research and Splicing
- Agricultural Economics and Practices
- Marine Sponges and Natural Products
- Synthesis and biological activity
- Health and Well-being Studies
- Diverse Scientific Research Studies
- HIV/AIDS drug development and treatment
- Global Maternal and Child Health
- vaccines and immunoinformatics approaches
- Organ Transplantation Techniques and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Neurological Complications and Syndromes
- Phytochemistry and biological activity of medicinal plants
- Essential Oils and Antimicrobial Activity
Dayanand Medical College & Hospital
2020-2025
Central University of Punjab
2019-2024
Adesh University
2020-2024
Navodaya Dental College and Hospital
2024
National Institute of Technology Rourkela
2024
University of Central Punjab
2024
Shobhit University
2024
All India Institute of Medical Sciences Rishikesh
2024
Jawaharlal Nehru Medical College Hospital
2023
Galgotias University
2023
Coronaviruses are contagious pathogens primarily responsible for respiratory and intestinal infections. Research efforts to develop antiviral agents against coronavirus demonstrated the main protease (Mpro) protein may represent effective drug target. X-ray crystallographic structure of SARS-CoV2 Mpro significance Glu166, Cys141, His41 residues involved in dimerization its catalytic function. We performed silico screening compounds from Curcuma longa L. (Zingiberaceae family) inhibition....
The present study explores the SARS-CoV-2 drugable target inhibition efficacy of phytochemicals from Indian medicinal plants using molecular docking, dynamics (MD) simulation, and MM-PBSA analysis. A total 130 were screened against Spike (S)-protein, RNA-dependent RNA polymerase (RdRp), Main protease (Mpro). Result docking showed that Isoquercetin potentially binds with active site/protein binding site Spike, RdRP, Mpro targets a score -8.22, -6.86, -9.73 kcal/mole, respectively. Further, MS...
AbstractThis study carried out in the month of April-June (2009) for which five rivers were chosen i.e. Alaknanda (A), Bhagirathi (B), Ganga (G), Mandakini (M) and Yamuna (Y). Water samples collected from nine monitoring stations viz. Devprayag (2), Gangotri (1), Haridwar Rudraprayag Dakpathar (1) Yamunotri (1). The analyzed physical, chemical microbiological parameters. sample temperatures ranged 7.8 - 280C, pH 7.02 8.16, turbidity 1-15 NTU, DO 6.3 – 10 mg/l BOD 1.4 4.5 mg/l. at showed nil...
At present, more than 200 countries and territories are directly affected by the coronavirus disease-19 (COVID-19) pandemic. Incidence case fatality rate significantly higher among elderly individuals (age > 60 years), type 2 diabetes hypertension patients. Cellular receptor ACE2, serine protease TMPRSS2 exopeptidase CD26 (also known as DPP4) three membrane bound proteins potentially implicated in SARS-CoV-2 infection. We hypothesised that common variants from may play critical role...
There is limited experience with the use of cinacalcet in treatment persistent secondary hyperparathyroidism after kidney transplantation.We retrospectively analyzed our 18 renal allograft recipients who initiated therapy from 1 month to 23 years (median 3 years) posttransplantation and were maintained on drug for 6 months. The daily dose was titrated 30 mg up a maximum 180 achieve reduction serum intact parathyroid hormone (PTH) levels.Sustainable, significant decreases mean calcium...
Only four centers have reported their results with renal transplantation in human immunodeficiency virus (HIV)+ recipients on highly active antiretroviral therapy, and acute rejection (AR) rates consistently ranged from 43% to 67%.We examined the outcomes of eight adult HIV+ primary allograft median 15 (range 8-47) months follow-up multiple other high-risk factors, including African American ethnicity, hepatitis C (HCV) positivity, long waiting times, prior sensitization, paucity live...
Drug-resistance-associated mutation in essential proteins of the viral life cycle is a major concern anti-retroviral therapy. M46I, non-active site HIV-1 protease has been clinically associated with saquinavir resistance HIV patients. A 100 ns molecular dynamics (MD) simulation and MM-PBSA calculations were performed to study mechanism M46I-mutation-based resistance. In order acquire deeper insight into drug-resistance mechanism, flap curling, closed/semi-open/open conformations, active...
Abstract Background The therapeutic landscape for ulcerative colitis (UC) has shifted toward deeper disease control. real-world data on efficacy of tofacitinib in inducing histologic remission (HR) remains limited. We evaluated the achieving endoscopic (ER) and HR. Methods A prospective cohort study was conducted from January 2022 to June 2024. Adult patients with moderate-to-severe UC (Mayo score ≥6, subscore ≥2), who responded induction were included. Paired assessments performed at...
Nano fertilizers are the modern day concept of and possess several benefits over conventional fertilizers. In very small quantity nano have significant impact on growth crop. The present study consisted 11 treatments utilising various combinations urea urea, administered at varied doses concentrations, with each treatment replicated three times in a Randomised Block Design. main objective experiment was to assess varying concentrations yield quality characteristics along shelf life...
A research study was carried out at the Horticulture Research Farm, Department of Horticulture, NAI, SHUATS, located in Prayagraj, Uttar Pradesh, during academic years 2022-23 and 2023-2024. The experiment comprised 11 treatments involving various combinations conventional urea nano urea, applied different levels concentrations, with each treatment replicated three times a Randomised Block Design. main objective to assess impact varying concentrations on growth characteristics Strawberry...
Due to scarcity of fossil fuel, the importance alternative energy sources is ever increasing. The oleaginous microalgae have demonstrated their potential as an source energy, but not achieved commercialization owing some biological and technical inefficiency. Modern methods recombinant strain development for improved efficacy are suffering due inadequate knowledge genome limited molecular tools available manipulation. In present study, microalga Scenedesmus quadricauda LWG002611 was selected...