This study aims to investigate the effect of pretreatment S-ketamine on postoperative depression (POD) for breast cancer patients with mild/moderate depression. The present randomized, double-blinded controlled trial included 303 from June 2017 2018. All were randomly divided into three groups: (1) control group, treated normal saline; (2) racemic ketamine ketamine; (3) S-ketamine. Operation time, blood loss and hospital stay complications recorded. Visual Analog Scale (VAS) score was...

This study aimed to investigate the protective effects and underlying mechanisms of cistanche on sevoflurane-induced aged cognitive dysfunction rat model. Aged (24 months) male SD rats were randomly assigned four groups: control group, sevoflurane + group. Subsequently, inflammatory cytokine levels measured by ELISA, was evaluated water maze test, open-field test fear conditioning test. Three days following anaesthesia, killed hippocampus harvested for analysis relative biomolecules. The...

Evolutionary Reinforcement Learning (ERL), which integrates Algorithms (EAs) and (RL) for optimization, has demonstrated remarkable performance advancements. By fusing the strengths of both approaches, ERL emerged as a promising research direction. This survey offers comprehensive overview diverse branches in ERL. Specifically, we systematically summarize recent advancements relevant algorithms identify three primary directions: EA-assisted optimization RL, RL-assisted EA, synergistic EA RL....

Surface nanocrystallization of metals and alloys via high-frequency ultrasonic shot peening (USP) can significantly increase the mechanical properties materials. However, relationship between external process parameters internal microstructure materials is still unclear an accurate numerical model to simulate USP urgently required for better control grain refinement process. In this study, we successfully realized surface 316L stainless steel using with frequency amplitude 20 kHz 50 μm,...

Abstract Background Sugammadex is a newer medication used for rapid and reliable reversal of neuromuscular blockade. This study evaluated whether sugammadex could reduce the length postoperative hospital stay in patients undergoing abdominal surgery. Methods single center retrospective cohort included who underwent major surgery between January 2015 October 2019. Patients were randomized according to with or spontaneous recovery. The primary outcome was stay. secondary outcomes...

Automatic speech recognition (ASR) that relies on audio input suffers from significant degradation in noisy conditions and is particularly vulnerable to interference. However, video recordings of capture both visual signals, providing a potent source information for training models. Audiovisual (AVSR) systems enhance the robustness ASR by incorporating lip movements associated sound production addition auditory input. There are many audiovisual models transcription, but most them have been...

<title>Abstract</title> Rolling bearing fault detection has developed rapidly in the field of diagnosis technology, and it occupies a very important position this field. Deep learning-based models have achieved significant success. At same time, with continuous improvement new signal processing technologies such as Fourier transform, wavelet transform empirical mode decomposition, technology rolling bearings also been greatly developed, can be said that entered research stage. However, most...

A S8-mediated directed decarboxylative redox-cyclization strategy for the synthesis of 2-substituted benzothiazoles from o-iodoanilines, arylacetic acids, and elemental sulfur catalyzed by cheap copper metal has been developed. This reaction is operationally simple, ligand-free, compatible with a wide range functional groups, provides desired products in good to excellent yields. In addition, gram-scale experiment was carried out furnish PMX 610, an antitumor drug.

Effects of volume-controlled ventilation vs . pressure-controlled on respiratory function and inflammatory factors in patients undergoing video-assisted thoracoscopic radical resection pulmonary carcinoma

Acute lung injury (ALI) is the common and clinically severe complication. Dexmedetomidine (DEX) can protect against lipopolysaccharide (LPS)-induced ALI through anti-apoptosis, anti-inflammatory immune regulatory actions. It well documented that major causes of LPS-induced are endoplasmic reticulum stress (ERS) abnormally elevated CHOP. Moreover, XBP-1 enhance CHOP expression. XBP-1S aggravate ERS U repress ERS. By querying Starbase, miR-135a-5p interacts with lncRNA MALAT1 sponges...

Deep Reinforcement Learning (Deep RL) and Evolutionary Algorithms (EA) are two major paradigms of policy optimization with distinct learning principles, i.e., gradient-based v.s. gradient-free. An appealing research direction is integrating RL EA to devise new methods by fusing their complementary advantages. However, existing works on combining have common drawbacks: 1) the agent agents learn policies individually, neglecting efficient sharing useful knowledge; 2) parameter-level guarantees...

Maintaining adequate oxygenation during one-lung ventilation (OLV) requires high inspired oxygen fraction (FiO2). However, FiO2 also causes inflammatory response and lung injury. Therefore, it remains a great interest to clinicians scientists optimize the care of patients undergoing OLV. The aim this study was determine compare oxygenation, injury OLV in rabbits using 0.6 vs. 1.0. After 30 minutes two-lung (TLV) as baseline, were randomly assigned three groups receiving mechanical for 3...

Discrete-continuous hybrid action space is a natural setting in many practical problems, such as robot control and game AI. However, most previous Reinforcement Learning (RL) works only demonstrate the success controlling with either discrete or continuous space, while seldom take into account space. One naive way to address RL convert unified homogeneous by discretization continualization, so that conventional algorithms can be applied. this ignores underlying structure of also induces...

Abstract Background High FiO 2 during one-lung ventilation (OLV) can improve oxygenation, but increase the risk of atelectasis and oxidative stress. The aim this study was to analyze whether Prostaglandin E 1 (PGE ) oxygenation attenuate stress OLV under a lower . Method Ninety patients selectively undergoing thoracotomy for esophageal cancer were randomly divided into three groups ( n = 30/group): Group P (FiO 0.6, inhaling PGE 0.1 μg/kg), L 0.6) C 1.0). primary outcomes pulmonary shunt...

There is no standard method by which to establish a right one-lung ventilation (OLV) model in rabbits. In the present study, novel proposed compare with two other methods. After 0.5 h of baseline two-lung (TLV), 40 rabbits were randomly divided into sham group (TLV for 3 as contrast) and three right-OLV groups (right OLV different methods): Deep intubation group, clamp blocker (deeply intubate self-made bronchial left main bronchus, method). These methods compared using number variables:...

Learning to collaborate is critical in Multi-Agent Reinforcement (MARL). Previous works promote collaboration by maximizing the correlation of agents' behaviors, which typically characterized Mutual Information (MI) different forms. However, we reveal sub-optimal collaborative behaviors also emerge with strong correlations, and simply MI can, surprisingly, hinder learning towards better collaboration. To address this issue, propose a novel MARL framework, called Progressive Collaboration...

Background: Sugammadex, a modified γ-cyclodextrin that selectively binds to muscle relaxants, is increasingly being used reverse neuromuscular blockade after surgery, but the potential benefits for cancer patients in real-world setting are obscure.

Abstract Background Prostaglandin E1 (PGE1) has been reported to maintain adequate oxygenation among patients under 60% FiO 2 one-lung ventilation (OLV). This research aimed explore whether PGE1 is safe in pulmonary shunt and 40% OLV provide a reference concentration of PGE1. Methods Totally 90 esophageal cancer treated with thoracotomy were enrolled this study, randomly divided into three groups (n = 30/group): Group A (60% 0.1 µg/kg PGE1), B (40% C , 0.2 PGE1). Primary outcomes during OLV....