A5055846948- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Oxidative Organic Chemistry Reactions
- Radical Photochemical Reactions
- Chemical Synthesis and Analysis
- Synthesis and Catalytic Reactions
- Bioactive natural compounds
- Chemical Synthesis and Reactions
- Bioactive Compounds and Antitumor Agents
- Synthesis and biological activity
Xinxiang Medical University
2019-2023
A protocol for visible-light-induced C-H acylation selectively at the C6 position of purine nucleosides with aldehydes under photocatalyst-free conditions was established herein. This allows green, mild, and efficient functionalization various a broad range alkyl aryl aldehydes.
para-Selective hydroxylation of alkyl aryl ethers is established, which proceeds with a ruthenium(II) catalyst, hypervalent iodine(III) and trifluoroacetic anhydride via radical mechanism. This protocol tolerates wide scope substrates provides facile efficient method for preparing clinical drugs monobenzone pramocaine on gram scale.
Daldinins are a novel type of naturally occurring tricyclic heterocycles isolated from Daldinia concentrica. In this study, four daldinin A derivatives with different alkyl side chains were synthesized using the same synthetic protocol. Bioactivity tests first indicated that showed significant protection for endothelial cells against damage caused by high glucose. The derivative compound three carbon atoms on exhibited best effect.
Phthalide is a common type of functional group in natural products and synthetic motifs, which has structural feature containing benzo five-membered lactone ring.Phthalide also popular pharmacophore many bioactive clinical drugs.This review focuses on chemical synthesis methods phthalides established the past ten years.