A5069143331- Inflammation biomarkers and pathways
- Transgenic Plants and Applications
- Research on Leishmaniasis Studies
- Neonatal and Maternal Infections
- Urticaria and Related Conditions
University of Iowa
2019-2024
Cutaneous leishmaniasis (CL) is a parasitic disease causing chronic, ulcerating skin lesions. Most humans infected with the causative Leishmania protozoa are asymptomatic. spp. usually introduced by sand flies into dermis of mammalian hosts in presence bacteria from either host skin, fly gut or both. We hypothesized that at dermal inoculation site major will influence severity infection ensues. A C57BL/6 mouse ear model single coinfection major, Staphylococcus aureus, both showed pathogen...
Abstract Asthma affects 25 million Americans, and recent advances in treatment are effective for only a portion of severe asthma patients. TREM-1, an innate receptor that canonically amplifies inflammatory signaling neutrophils monocytes, plays central role regulating lung inflammation. It is unknown how TREM-1 contributes to allergic pathology. Utilizing murine model asthma, flow cytometry revealed TREM-1+ eosinophils the tissue airway during expression was restricted recruited,...
Abstract Inflammatory agents, microbial products, or stromal factors pre-activate prime neutrophils to respond activating stimuli in a rapid and aggressive manner. Primed exhibit enhanced chemotaxis, phagocytosis, respiratory burst when stimulated by secondary stimuli. We previously reported that Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) mediates neutrophil effector functions such as increased superoxide generation, transepithelial migration, chemotaxis. However, it is...