A5015639016- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Infective Endocarditis Diagnosis and Management
- Transplantation: Methods and Outcomes
- Cardiac pacing and defibrillation studies
- Aortic Disease and Treatment Approaches
- Congenital Heart Disease Studies
- Cystic Fibrosis Research Advances
- Cardiac tumors and thrombi
- Heart Failure Treatment and Management
- Advanced Causal Inference Techniques
- Frailty in Older Adults
- Hemodynamic Monitoring and Therapy
- Intensive Care Unit Cognitive Disorders
- Organ Transplantation Techniques and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiovascular Issues in Pregnancy
- Coronary Artery Anomalies
- Pulmonary Hypertension Research and Treatments
- Geriatric Care and Nursing Homes
- Tracheal and airway disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
London School of Hygiene & Tropical Medicine
2021-2025
St Vincent's Hospital Sydney
2015-2024
UNSW Sydney
2012-2024
St Vincent's Health
2014-2024
New Zealand Association of Counsellors
2023
St Vincent's Hospital
2008-2022
East Lancashire Hospitals NHS Trust
2022
Society of Interventional Radiology
2022
Sydney Children's Hospital
2018-2022
University Hospitals of Morecambe Bay NHS Foundation Trust
2022
Overcoming bias due to confounding and missing data is challenging when analyzing observational data. Propensity scores are commonly used account for the first problem multiple imputation latter. Unfortunately, it not known how best proceed both techniques required. We investigate whether two different approaches combining propensity (Across Within) lead differences in accuracy or precision of exposure effect estimates. Both start by imputing values times. then estimated each resulting...
Left ventricular assist device (LVAD) therapy has been used primarily in patients with end-stage dilated cardiomyopathy (DCM), and hypertrophic (HCM) are generally excluded. We compared outcomes 3 HCM 36 DCM patients. While had smaller left end-diastolic dimensions, average pump flows for the two groups were similar. All marked improvement mean pulmonary arterial pressures cardiac index at 5 months. This analysis shows that heart failure resulting from do benefit centrifugal cfLVAD short to...
The aim of this study was to determine the contribution pre-load and heart rate pump flow in patients implanted with continuous-flow left ventricular assist devices (cfLVADs).Although it is known that cfLVAD increases exercise, unclear if increment driven by increased rate, augmented intrinsic contraction, or enhanced venous return.Two studies were performed HeartWare HVAD. In 11 patients, paced approximately 40 beats/min above baseline then down 30 below pacing (in pacemaker-dependent...
Introduction Target trial emulation is a framework for evaluating the effects of treatments using observational data. The approach involves specifying key elements protocol target (a randomised controlled designed to address question interest) and then describing how best emulate Recent years have seen an uptake in several disease areas, although there are limited examples cystic fibrosis (CF). This describes study which aims assess applicability CF. We aim existing CF what extent results...
G-formula is a popular approach for estimating the effects of time-varying treatments or exposures from longitudinal data. typically implemented using Monte-Carlo simulation, with non-parametric bootstrapping used inference. In data settings missing are common issue, which often handled multiple imputation, but it unclear how and imputation should be combined. We show can Bayesian methods synthetic data, that by doing so, we impute simulate counterfactuals interest within single coherent...
Both implantable cardioverter defibrillators (ICDs) and left ventricular assist devices (LVADs) have a positive impact on survival in the heart failure population. We sought to determine whether these effects are additive or LVAD therapy supersedes ICD therapy.We analyzed data of patients implanted with nonpulsatile LVADs between October 2004 March 2013. Survival ICDs (n = 64) was compared those without 36). Patients exited study at time transplantation death.A total 100 underwent...
Background: Engaging in regular physical activity has a beneficial impact on both health and subjective indicators. The aims of this study were (i) to assess the association between levels self-reported status European adolescents (ii) identify any differences distribution reporting good active inactive subjects across urban areas. Methods: sample comprised 13 783 15-year olds from 21 areas Europe who participated Urban Health Indicators System Part 2 youth survey 2010/11. Data collected...
Abstract The current recommended anticoagulation regimen during continuous flow centrifugal left ventricular device support is a combination of antiplatelet therapy as well oral anticoagulation. Despite this, pump thrombosis occurs in rare situations. We report the risk factors and nonsurgical management outcomes five patients implanted with assist devices who displayed clinical, hemodynamic, laboratory features intrapump thrombosis. This information may use intravenous thrombolytics for...
Background Cystic fibrosis (CF) is a life-threatening genetic disease, affecting around 10 500 people in the UK. Precision medicines have been developed to treat specific CF-gene mutations. The newest, elexacaftor/tezacaftor/ivacaftor (ELEX/TEZ/IVA), has found be highly effective randomised controlled trials (RCTs) and became available large proportion of UK CF patients 2020. Understanding potential health economic impacts ELEX/TEZ/IVA vital planning service provision. Methods We combined...
BiVACOR is a novel total artificial heart (TAH) utilizing single centrifugal magnetically levitated rotor with the ability to modulate pulsatile flow. The device has been successfully tested in bovine model. We undertook multicenter anatomical and virtual fitting study of patients undergoing transplantation.10 were recruited across two transplant centers. A sterilized 1:1 titanium model was inserted into patient's chest post explant, prior implantation donor heart. Measurements recorded...
In the current era of heart transplantation, machine perfusion strategies are emerging as potential additions to armamentarium a transplant unit. Donation after circulatory death (DCD) donor hearts assessed through normothermic (NMP) has helped expand pool. Hypothermic (HMP) is an alternative strategy traditional static cold storage (SCS) when prolonged ischemic time anticipated in brain dead (BD) donors, this important Australia where long distant procurement vital. study we examine...
Continuous flow left ventricular assist devices (cfLVADs) are used in clinical practice for the management of end-stage heart failure. Axial cfLVADS have been associated with increased rates adverse gastrointestinal events such as bleeding angiodysplasia. The purpose this study was to determine incidence tract angiodysplasia and profile patients supported centrifugal cfLVAD, referred endoscopy.A retrospective analysis 66 implanted Ventrassist (n = 33) Heartware continuous LVADs performed....
BackgroundIn late 2012, ivacaftor became available in the UK for people with cystic fibrosis (CF) aged 6 years and over a G551D mutation. Long-term changes treatment patterns have not previously been reported. We investigated long-term CF mutation who took compared these non-ivacaftor-treated cohorts using Cystic Fibrosis Registry.MethodsUsing 2007-2018 data we between four cohorts: 1: ivacaftor-treated; 2: era (2013-2018), ineligible genotype (no mutation); 3: pre-ivacaftor (2007-2012),...