A5102758750- Genetic Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Memory and Neural Mechanisms
- Mitochondrial Function and Pathology
- Acute Ischemic Stroke Management
- Neural dynamics and brain function
- Transcranial Magnetic Stimulation Studies
- Coronary Artery Anomalies
- Complex Network Analysis Techniques
- Artificial Intelligence in Healthcare and Education
- Parkinson's Disease Mechanisms and Treatments
- Sleep and Wakefulness Research
- Advanced Graph Neural Networks
- Motor Control and Adaptation
- Intracerebral and Subarachnoid Hemorrhage Research
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Congenital heart defects research
- Machine Learning in Healthcare
- Neurosurgical Procedures and Complications
- Neurological diseases and metabolism
- Supply Chain and Inventory Management
- MicroRNA in disease regulation
- Atrial Fibrillation Management and Outcomes
Affiliated Hospital of Hangzhou Normal University
2016-2025
University of Otago
2009-2024
Brain Research New Zealand
2017-2024
Biogen (United States)
2024
Beihang University
2023
Broad Institute
2016-2022
Hangzhou Normal University
2022
China University of Petroleum, East China
2020
State Key Laboratory of Industrial Control Technology
2019
Sichuan Economic Management Cadre College
2019
Profiling post-translational modifications represents an alternative dimension to gene expression data in characterizing cellular processes. Many responses drugs are mediated by changes phosphosignaling. We sought develop a common platform on which phosphosignaling could be profiled across thousands of samples, and created targeted MS assay that profiles reduced-representation set phosphopeptides we show strong indicators chemical perturbagens.To the assay, investigated coordinate regulation...
Background With the rise of artificial intelligence (AI) in field dementia biomarker research, exploring its current developmental trends and research focuses has become increasingly important. This study, using literature data mining, analyzes assesses key contributions development scale AI research. Objective The aim this study was to comprehensively evaluate state, hot topics, future globally. Methods thoroughly analyzed application biomarkers across various dimensions, such as...
Abstract Hippocampal place cells have the interesting property of increasing their firing rate when a freely moving animal increases its running speed through cell's field. A previous study from this laboratory showed that movement‐related is disrupted by lesions perirhinal cortex (PrhC). It possible, therefore, PrhC disrupt speed‐modulated sensory information such as optic flow or motor efferent proprioceptive input might be available to hippocampus PrhC. To test hypothesis, rats with...
Acute brainstem syndrome (ABS) may herald multiple sclerosis (MS), neuromyelitis optica (NMO), or occur as an isolated syndrome. The aquaporin 4 (AQP4)-specific serum autoantibody, NMO-IgG, is a biomarker for NMO. However, the role of anti-AQP4 antibody in conversion ABS to NMO unclear.Thirty-one patients with first-event were divided into two groups according presence antibodies, their clinical features and outcomes retrospectively analyzed.Fourteen 31 (45.16 %) seropositive NMO-IgG. 71.43...
Objective To investigate the effectiveness of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) on improvement clinical symptoms in patients with spinocerebellar ataxia type 3 (SCA3). Methods Sixteen SCA3 participants diagnosed by genetic testing were enrolled this sham-controlled and double-blind trial. They received either a 2-week 10-Hz rTMS intervention or sham targeting vermis cerebellum. The Scale for Assessment Rating Ataxia International Cooperative completed at...
Abstract The neural circuitry mediating sensory and motor representations is adaptively tuned by an animal's interaction with its environment. Similarly, higher order such as spatial memories can be modified exposure to a complex environment (CE), but in this case the changes brain that mediate effect are less well understood. Here, we show prolonged CE was associated increased selectivity of CA1 “place cells” particular recording arena compared social control (SC) group. Furthermore, fewer...
An increasing number of resting-state functional magnetic resonance neuroimaging (R-fMRI) studies have used connections as discriminative features for machine learning to identify patients with brain diseases. However, it remains unclear which could serve highly realize the classification autism spectrum disorder (ASD). The aim this study was find ASD-related connectivity patterns and examine whether these had potential provide neuroimaging-based information clinically assist diagnosis ASD...
Information propagation on social networks could be modeled as cascades, and many efforts have been made to predict the future popularity of cascades. However, most existing research treats a cascade an individual sequence. Actually, cascades might correlated with each other due shared users or similar topics. Moreover, preferences semantics are usually continuously evolving over time. In this paper, we propose continuous-time graph learning method for prediction, which first connects...
OBJECTIVE Mechanical thrombectomy using a Solitaire stent retriever has been widely applied as safe and effective method in adult acute ischemic stroke (AIS). However, due to the lack of data, safety effectiveness mechanical pediatric AIS not yet verified. The purpose this study was explore for AIS. METHODS Between January 2012 December 2017, 7 cases were treated via retriever. clinical practice, imaging, follow-up results reviewed, data summarized analyzed. RESULTS ages patients ranged from...
Abstract The pedunculopontine tegmental nucleus of the brainstem (PPTg) has extensive interconnections and neuronal‐behavioural correlates. It is implicated in movement control sensorimotor integration. We investigated whether single neuron activity freely moving rats correlated with components skilled forelimb movement, individual neurons respond to both motor sensory events. found that PPTg showed changes firing rate at different times during reach. This type temporally specific modulation...
Spinal motor neuron (MN) dysfunction is the cause of a number clinically significant movement disorders. Despite recent approval gene therapeutics targeting these MN-related disorders, there are no viral delivery mechanisms that achieve MN-restricted transgene expression. In this study, chromatin accessibility profiling genetically defined mouse MNs was used to identify candidate cis-regulatory elements (CREs) capable driving MN-selective Subsequent testing candidates identified two CREs...
Purpose – The purpose of this paper is to examine the trade relationship between China and other developing countries, analyze regional structure commodity composition, give policy advice promote economic ties them then investigate foundation South‐South cooperation.
Qiu, Mengqiu MD; Chen, Yuchao Li, Dan Jin, Yi Xu, Ting Huang, Ziyang Lu, Xiaodong MD, PhD Author Information