A5057302133- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- interferon and immune responses
- Analytical Chemistry and Chromatography
- Chromosomal and Genetic Variations
- thermodynamics and calorimetric analyses
- DNA and Nucleic Acid Chemistry
- Plant tissue culture and regeneration
Duke University
2016-2019
Durham Technical Community College
2017
NMR-guided evolution of the pyrazine C(5)- and C(6)-positions amiloride reveals a tunable scaffold for selective RNA interactions.
Three-dimensional RNA structures are notoriously difficult to determine, and the link between secondary structure conformation is only beginning be understood. These challenges have hindered identification of guiding principles for small molecule:RNA recognition. We herein demonstrate that strong differential binding ability aminoglycosides can used classify five canonical motifs through principal component analysis (PCA). In these analyses, act as receptors, while labeled with a...
Conformational changes in RNA play vital roles the regulation of many biological systems, yet these can be challenging to visualize. Previously, we demonstrated that Pattern Recognition by Small Molecules (PRRSM) unbiasedly cluster defined secondary structure motifs utilizing an aminoglycoside receptor library. In this work, demonstrate power method visualize folding at level within two distinct riboswitch structures. After labeling three independent positions on each riboswitch, PRRSM...
Using pattern recognition of RNA with small molecules (PRRSM) fluorescent chemosensors and aminoglycosides, we reveal the impact changing environmental conditions on differentiation a range structures as well ability to predict different sequence/size compositions five canonical motifs.