A5101490306- Diet and metabolism studies
- Advanced Drug Delivery Systems
- Pharmacology and Obesity Treatment
- Seaweed-derived Bioactive Compounds
- Carbohydrate Chemistry and Synthesis
- Helicobacter pylori-related gastroenterology studies
- Nutritional Studies and Diet
- Gastroesophageal reflux and treatments
- Glycosylation and Glycoproteins Research
- Drug Solubulity and Delivery Systems
- Dysphagia Assessment and Management
- Protein Hydrolysis and Bioactive Peptides
- Food composition and properties
- Tracheal and airway disorders
- Pineapple and bromelain studies
- Bacterial biofilms and quorum sensing
- RNA Interference and Gene Delivery
- Gastrointestinal motility and disorders
- Oral and gingival health research
- Muscle metabolism and nutrition
- Respiratory Support and Mechanisms
- Esophageal and GI Pathology
- Biochemical Analysis and Sensing Techniques
- Microbial Metabolites in Food Biotechnology
- Diabetes Treatment and Management
Michigan State University
2024
Sparrow Hospital
2023-2024
Newcastle University
2010-2023
Newcastle upon Tyne Hospital
2015-2021
Episcopal Divinity School
1958
St. Mary's College
1958
Bournville College
1958
Museum Boerhaave
1958
Alginates are comprised of mannuronic (M) and guluronic acid (G) have been shown to inhibit enzyme activity. Pancreatic lipase is important in dietary triacylglycerol breakdown; reducing pancreatic activity would reduce breakdown resulting lower amounts being absorbed by the body. Lipase presence biopolymers was assessed enzymatic assay using natural synthetic substrates. Alginate inhibited a maximum 72.2% (±4.1) with substrate (DGGR) 58.0% (±9.7) substrate. High-G alginates from Laminaria...
Abstract The high antibiotic resistance of Pseudomonas aeruginosa (PA) makes it critical to develop alternative antimicrobial agents that are effective and affordable. One the many applications silver nanoparticles (Ag NPs) is their use as an agent against bacteria resistant common antibiotics. key purpose this research was assess antibacterial antibiofilm effectiveness biosynthesized Ag NPs six biofilm-forming clinically isolated strains PA one reference strain (ATCC 27853). were using a...
Alginates are classed as a dietary fibre and have been shown to inhibit digestive enzymes in vitro, therefore could be used an obesity treatment. The current study aims assess whether alginate bread vehicle maintains its inhibition properties despite cooking digestion, may potential treatment for obesity. After 180 min model gut that replicates digestion the mouth, stomach small intestines (AB), control (CB), CB with Manucol® DM alginate, free solution were collected. DM, LFR 5/60 SF200...
Aim: Aim of the study was development ζ potential changing nanoparticles as gene delivery system for cystic fibrosis transmembrane conductance regulator gene. Methods: Chitosan and carboxymethyl cellulose were modified with phosphotyrosine, a substrate brush border enzyme alkaline phosphatase. With these synthesized derivatives, different nanoparticle formulations, including prepared by ionic gelation. Results: A change from negative to positive after enzymatic cleavage could be observed....
MUC2 mucin, the primary gel-forming component of intestinal mucus, is well researched and a model polymerisation post-secretory organisation has been published previously. Recently, several significant developments have made which either introduce new ideas or challenge previous theories. New include an overhaul C-terminal globular structure proposed to harbour previously unobserved domains, site for extra intermolecular disulphide bridge dimer between cysteine 4379 adjacent C-termini....
Lifestyle interventions and physical activity remain the cornerstone of obesity management, as pharmacological therapies (orlistat) are associated with gastrointestinal (GI) side effects. Combining orlistat fibers can reduce effects, improving compliance. Therefore, a fiber that inhibits lipase without effects could help treat obesity. The aims present work were to assess whether alginate enriched bread inhibit fat digestion, acceptability its effect on GI wellbeing. A double-blind,...