A5042305109- Traumatic Brain Injury Research
- Posttraumatic Stress Disorder Research
- Occupational Health and Performance
- Noise Effects and Management
- Older Adults Driving Studies
- SARS-CoV-2 and COVID-19 Research
- Functional Brain Connectivity Studies
- COVID-19 Clinical Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Respiratory viral infections research
- Hearing Loss and Rehabilitation
- COVID-19 and Mental Health
- COVID-19 epidemiological studies
- Automotive and Human Injury Biomechanics
- Air Quality and Health Impacts
- Injury Epidemiology and Prevention
- Anesthesia and Neurotoxicity Research
- SARS-CoV-2 detection and testing
- Health, Environment, Cognitive Aging
- Advanced Neuroimaging Techniques and Applications
Stony Brook University
2020-2024
Stony Brook School
2020-2023
Florida International University
2022
University of Maryland, Baltimore
2022
Introduction This study examined cortical thickness (CTX) in World Trade Center (WTC) responders with cognitive impairment (CI). Methods WTC (N = 99) with/without CI, recruited from an epidemiologic study, completed a T1-MPRAGE protocol. CTX was automatically computed 34 regions of interest. Region-based and surface-based morphometry CI versus unimpaired responders. measures were also compared to published norms. Results Participants 55.8 (SD 0.52) years old; 48 had CI. Compared responders,...
Abstract Prior research has demonstrated high levels of cognitive and physical functional impairments in World Trade Center (WTC) responders. A follow-up neuroimaging study identified changes to white matter connectivity within the cerebellum responders with impairment (CI). In first examine cerebellar cortical thickness WTC CI, we fielded a structural magnetic resonance imaging protocol. ( N = 99) participated (MRI) study, whom 48 had CI. Participants CI did not differ demographically or by...
Abstract Approximately 23% of World Trade Center (WTC) responders are experiencing chronic posttraumatic stress disorder (PTSD) associated with their exposures at the WTC following terrorist attacks 9/11/2001, which has been demonstrated to be a risk factor for cognitive impairment raising concerns regarding brain health. Cortical complexity, as measured by analyzing Fractal Dimension (FD) from T 1 MRI images, reported reduced in variety psychiatric and neurological conditions. In this...
Abstract Introduction The objective of this study was to investigate associations between dementia in World Trade Center (WTC) responders and vivo volumetric measures hippocampal subfield volumes WTC at midlife. Methods A sample 99 divided into unimpaired groups. Participants underwent structural T1‐weighted magnetic resonance imaging. Volumetric included the overall hippocampus eight subfields. Regression models examined measure interest adjusting for confounders including intracranial...
Abstract Background Recent reports suggest that World Trade Center (WTC) responders are at increased risk for cognitive impairment (CI). The current study utilized neuroimaging to determine whether WTC with CI have reduced cortical thickness (CTX). Method (N=99) and without CI, recruited from an epidemiologic of aging among responders, participated in a included T1‐MPRAGE protocol. CTX was computed 34 Desikan‐Killiany atlas regions interest (ROIs). Regional between non‐CI were compared using...
Abstract Responders to the World Trade Center (WTC) attacks on 9/11/2001 inhaled toxic dust and experienced severe trauma for a prolonged period. Studies report that WTC site exposure duration is associated with peripheral inflammation risk developing early-onset dementia (EOD). Free Water Fraction (FWF) can serve as biomarker neuroinflammation by measuring in vivo movement of free water across neurons. The present case-controlled study aimed examine associations between well EOD status...
World Trade Center (WTC) responders have a high risk of early-onset cognitive impairment (CI), but little is known about the etiology including extent to which CI in WTC accompanied by cortical atrophy as common progressive diseases causing age-related such Alzheimer's disease and related dementias. In current study, we entrained an artificial neural network (ANN) determine accuracy thickness (CTX) on magnetic resonance imaging identify at midlife (aged 44-65 years) with possible dementia.A...
More than 8% of responders who participated in the search and rescue efforts at World Trade Center (WTC) following 9/11 developed early-onset cognitive impairment (CI). Approximately 23% were also diagnosed with chronic post-traumatic stress disorder (PTSD).
Purpose Incidence of early onset neurocognitive dysfunction has been reported in World Trade Center (WTC) responders. Ongoing studies are investigating the underlying etiology, as we concerned that an risk neurodegenerative dementia may be occurring because their stressful and neurotoxic exposures to particulate matter when they responded search rescue efforts on September 11, 2001. The purpose this study is report preliminary results from two ongoing positron emission tomography...
Posttraumatic stress disorder (PTSD) has been linked to increased risk of cognitive dysfunction and physical functional impairment (PFI). The objective this prospective cohort study was examine whether PFI associated with incident mild (MCI) among World Trade Center (WTC) responders PTSD. We hypothesized that PTSD would have an elevated MCI mediate increase.
Little is known about the characteristics and causes of early-onset cognitive impairment. Responders to 2001 New York World Trade Center disaster represent an ageing population that was recently shown have excess prevalence Neuroimaging molecular data demonstrate a subgroup affected responders may unique form parietal-dominant Alzheimer's Disease. Recent neuropsychological testing artificial intelligence approaches emerged as methods can be used identify monitor subtypes We utilized from...
Abstract World Trade Center (WTC) responders exposed to traumatic and environmental stressors during rescue recovery efforts have a high prevalence of chronic WTC-related post-traumatic stress disorder (WTC-PTSD). We investigated neural mechanisms underlying WTC-PTSD by applying eigenvector centrality (EC) metrics data-driven methods on resting state functional magnetic resonance (fMRI). identified how EC differences relate WTC-exposure behavioral symptoms. found that connectivity...
The men and women involved in rescue recovery operations at the 9/11 World Trade Center (WTC) site have a greater prevalence (23%) of persistent, clinically significant post-traumatic stress disorder (PTSD). Recent structural functional magnetic resonance imaging (MRI) studies demonstrate neural differences between WTC responders with without PTSD. Here, we used brain age, novel MRI-based data-driven biomarker optimized to detect accelerated aging, examined impact PTSD on this process. Using...
Background Amyloid-β proteins, a hallmark of Alzheimer's disease, are believed to play an adaptive role in the cerebral immune response. Objective Amyloid is response and could similar air pollution exposures. In present study, we examined whether WTC exposure duration was associated with amyloidosis responders. Methods responders (aged 44–65 years) who varied but did not use personalized protective equipment were assessed using positron-emission tomography [ 18 F]-Florbetaben. The outcome...
Abstract World Trade Center (WTC) responders exposed to traumatic and environmental stressors during rescue recovery efforts have higher prevalence (23%) of persistent, clinically significant WTC-related post-traumatic stress disorder (WTC-PTSD). Here, we applied eigenvector centrality (EC) metrics data driven methods on resting state functional magnetic resonance (fMRI) outcomes investigate neural mechanisms underlying WTC-PTSD identify how EC shifts in brain areas relate WTC-exposure...
World Trade Center (WTC) responders demonstrate elevated risk for cognitive impairment (CI) consistent with Alzheimer's Disease and Related Dementias (ADRD). Neuropsychological test performance is valuable in early detection efforts non-invasive longitudinal tracking of populations at ADRD. We hypothesized that WTC-CI would be associated a greater number errors on the clock drawing task (CDT).The CDT was administered to with/without CI who participated case/control study. diagnosed following...
Objective: Functional connectivity of the default mode network (DMN) during rest has been shown to be different among adults with Mild Cognitive Impairment (MCI) relative aged-matched individuals without MCI and is predictive transition dementia. Post-traumatic stress disorder (PTSD) also associated aberrant DMN. Prior work from this group demonstrated a higher rate PTSD World Trade Center (WTC) responders general population. The current study sought investigate main interactive effects on...
Introduction: World Trade Center (WTC) responders have high prevalence (23%) of persistent, clinically significant WTC-related post-traumatic stress disorder (PTSD). Recent structural magnetic resonance imaging (MRI) studies demonstrate anatomical differences between WTC with and without PTSD. We used resting state functional (rs-fMRI) to investigate neural mechanisms underlying WTC-PTSD identify changes in local brain areas associated exposure. Methods: Using graph theory analysis rs-fMRI...
Abstract Background Though the Montreal Cognitive Assessment (MoCA) is validated for cross‐sectional assessment, there limited guidance as to methods reliably identifying incident cases of Mild Impairment (MCI) and dementia. The goal this study was examine characteristics individuals identified having MCI dementia using different diagnostic routines. Methods World Trade Center (WTC) responders are a unique population, not only because historic significance traumatic exposures many endured...