A5070787383- Peptidase Inhibition and Analysis
- FOXO transcription factor regulation
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Signaling Pathways in Disease
- RNA modifications and cancer
- Hippo pathway signaling and YAP/TAZ
- Autophagy in Disease and Therapy
- Cancer Mechanisms and Therapy
- PARP inhibition in cancer therapy
- Ubiquitin and proteasome pathways
First Affiliated Hospital of Nanchang University
2022-2024
Nanchang University
2022-2023
Abstract Background Large tumor suppressor kinase 1 (LATS1), one of the predominant components Hippo pathway, has been characterized as a key player controlling proliferation and invasion cancer cells, including gastric (GC) cells. However, mechanism by which functional stability LATS1 is modulated yet to be elucidated. Methods Online prediction tools, immunohistochemistry western blotting assays were used explore expression WW domain-containing E3 ubiquitin ligase 2 (WWP2) in GC cells...
Aberrant expression of tripartite motif 11 (TRIM11) and the Wnt/β-catenin pathway are essential for facilitating tumorigenesis progression in multiple types cancer. To investigate molecular changes linking dysregulation TRIM11 activation gastric cancer (GC) progression. The levels were detected GC tissues cells by immunohistochemistry western blotting. role growth, proliferation, invasion was observed a series cell functional experiments further verified vivo. Co-immunoprecipitation (Co-IP),...
Abstract Mounting evidence has proposed the importance of Wnt/β-catenin pathway and tripartite motif 31 (TRIM31) in certain malignancies. Our research aimed to clarify correlation between aberrant TRIM31 expression during gastric cancer (GC) oncogenesis development. was drastically elevated GC tissues closely associated with aggressive clinical outcomes poor prognosis. Moreover, downregulation attenuated cell proliferation invasion vitro. Mechanistically, could bind ubiquitinate Axin1...
Abstract Despite the importance of radiation therapy as a nonsurgical treatment for non-small cell lung cancer (NSCLC), resistance has always been concern because poor patient response and outcomes. Therefore, it is crucial to identify novel targets increase effectiveness radiotherapy investigate mechanisms underlying radioresistance. Previously, we demonstrated that Spindlin 1 (SPIN1) was related tumour initiation progression. In this study, found SPIN1 expression higher in NSCLC tissues...
Abstract Background Radioresistance is a predominant obstacle of effective treatments in non-small cell lung cancer (NSCLC), while the underlying mechanism remains incompletely elucidated. Spindlin 1(SPIN1) has been reported to participate tumor initiation and progression. Herein, this study aims explore role SPIN1 NSCLC progression radioresistance. Methods Bioinformatics analysis, immunohistochemistry (IHC) western blotting were performed test expression samples lines. The carcinogenic was...