A5044655916- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Nanoplatforms for cancer theranostics
- Immune Response and Inflammation
- CAR-T cell therapy research
- Advanced Biosensing Techniques and Applications
- Antimicrobial agents and applications
- Bacteriophages and microbial interactions
- Advanced biosensing and bioanalysis techniques
- Immune Cell Function and Interaction
- Medical and Biological Ozone Research
- Erythrocyte Function and Pathophysiology
- vaccines and immunoinformatics approaches
- Advanced Nanomaterials in Catalysis
- Ocular Surface and Contact Lens
- Quantum Dots Synthesis And Properties
- Bacterial Infections and Vaccines
- Cancer Immunotherapy and Biomarkers
University of Maryland, College Park
2014-2022
United States Army Combat Capabilities Development Command
2019
Recent studies reveal many biomaterial vaccine carriers are able to activate immunostimulatory pathways, even in the absence of other immune signals. How changing properties polymers during biodegradation impact this intrinsic immunogenicity is not well studied, yet information could contribute rational design degradable that help direct response. We use poly(beta-amino esters) (PBAEs) explore as a function degree polymer degradation and form (e.g., soluble, particles). PBAE particles...
Treatments for autoimmunity - diseases where the immune system mistakenly attacks self-molecules are not curative and leave patients immunocompromised. New studies aimed at more specific treatments reveal development of inflammation or tolerance is influenced by form self-antigens presented. Using a mouse model multiple sclerosis (MS), we show first time that quantum dots (QDs) can be used to generate immunological controlling density self-antigen on QDs. These assemblies display dense...
Autoimmune diseases occur when the immune system incorrectly recognizes self-molecules as foreign; in case of multiple sclerosis (MS), myelin is attacked. Intriguingly, new studies reveal toll-like receptors (TLRs), pathways usually involved generating responses against pathogens, play a significant role driving autoimmune disease both humans and animal models. We reasoned polyplexes formed from self-antigen regulatory TLR antagonists might limit signaling during differentiation...
Vaccines and immunotherapies that elicit specific types of immune responses offer transformative potential to tackle disease. The mechanisms governing the processing signals-events determine type response generated-are incredibly complex. Understanding these processes would inform more rational vaccine design by linking carrier properties, mechanisms, relevant timescales impacts on response. This goal is pursued using nanostructured materials-termed polyelectrolyte multilayers-built entirely...
Local signal integration in lymph nodes (LNs) controls the potency and selectivity of immune responses. Here, intra-LN depots were used to direct communication within treated LNs, causing programmable divergent systemic immunotherapy outcomes.
In article number 1700290, Christopher M. Jewell and co-workers use quantum dots (yellow) to track control the display density of self-molecules mistakenly attacked during autoimmune diseases. This precise changes self-molecule processing by antigen-presenting cells (purple), reprogramming disease-driving inflammatory T (red) become regulatory (developing white region on cell) that disease eliminate paralysis.
Abstract Myelin, a matrix that insulates the axons of neurons, is attacked by immune system in multiple sclerosis (MS), leading to neurodegeneration. MS treatments are currently limited because they non-curative and broadly-acting immunosuppressants can leave patients immunocompromised. Recent reports show co-delivery myelin peptides (MOG) along with regulatory signals promote tolerance rather than cause inflammation. New studies reveal inflammatory toll-like receptors (TLRs) play...