A5030016673- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Hernia repair and management
- Esophageal Cancer Research and Treatment
- Minimally Invasive Surgical Techniques
- Pelvic and Acetabular Injuries
- Surgical Simulation and Training
- Bariatric Surgery and Outcomes
- Congenital Diaphragmatic Hernia Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Gastrointestinal disorders and treatments
- Nutrition and Health in Aging
- Dysphagia Assessment and Management
- Anatomy and Medical Technology
- Colorectal Cancer Surgical Treatments
- Frailty in Older Adults
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Adipokines, Inflammation, and Metabolic Diseases
- Ethics in Clinical Research
- Legume Nitrogen Fixing Symbiosis
- Abdominal Surgery and Complications
- Anesthesia and Sedative Agents
- Pelvic floor disorders treatments
- Patient-Provider Communication in Healthcare
Medical College of Wisconsin
2013-2017
University Hospital Bratislava
2016
Comenius University Bratislava
2016
Presidency University
2015
Objective: Despite widespread use of proton pump inhibitors (PPIs), the incidence esophageal adenocarcinoma (EAC) continues to rise. PPIs reduce reflux acidity, but only transiently inactivate gastric enzymes. Nonacid reflux, specifically nonacid pepsin, contributes carcinogenesis in larynx. Given carcinogenic potential pepsin and inefficacy prevent EAC, presence effect esophagus should be investigated. Methods: Normal Barrett’s biopsies from 8 patients were collected for analysis via...
Previous randomized controlled trials have demonstrated that partial fundoplication following Heller myotomy results in less pathologic acid exposure to the esophagus when compared without fundoplication. Recent studies questioned necessity of a fundoplication, especially limited hiatal dissection (LHD) is performed and angle His preserved.This retrospective review prospectively maintained data. All patients underwent primary for achalasia over 30-month period. In select patients, an LHD was...
<p class="abstract"><strong>Background:</strong> Electronic consent for research has shown success in clinical trial models, but not been rigorously evaluated as an alternative to conventional paper consent. We sought design a 21 CFR Part 11 compliant iPad-based electronic Informed Consent Form (eICF) with Research Data Capture (REDCap). As secondary aim, we compare subject workload between eICF and groups.</p><p...
We sought to characterize the changes in esophagogastric junction (EGJ) distensibility during Heller Myotomy with Dor fundoplication using EndoFLIP device. Intraoperative measurements on 14 patients undergoing myotomy were conducted over an 18-month period. Minimum esophageal diameter, cross-sectional areas, and index measured at 30 40 mL catheter volumes before myotomy, postmyotomy, following fundoplication. Distensibility is defined as narrowest area divided by corresponding pressure...
Evidence for naturally occurring programmed cell death in Marchantia polymorpha tuberculate rhizoids as a function of age is described. Membrane degradation and DNA fragmentation, two major events that occur during death, are detected quantified using Trypan Blue staining the TUNEL Assay. permeability fragmentation both increase aged. Spermine suppressed this response; hydrogen peroxide accelerated it. This research has advanced study PCD by demonstrating nutrient recycling thallus interrelated.
Purpose: We sought to evaluate the feasibility, safety, and difficulty of performing per-oral endoscopic myotomy (POEM) procedure in setting a prior Heller using survival porcine model. Methods: Four pigs underwent laparoscopic with Dor partial anterior fundoplication followed by POEM performed 4 weeks later. Two additional served as controls, undergoing only POEM. Results: All procedures were completed without complications. The revisional was not significantly more difficult than controls...
Introduction: Peripheral adiposity is associated with better metabolic health and higher plasma adiponectin (ADPN) levels. Since ADPN secreted mainly by adipose tissue (AT), it intriguing that visceral (VAT) lower levels poor health. Hypothesis: We hypothesized various AT depots differ in their ability to secrete ADPN. Methods: Paired samples (VAT subcutaneous (SAT)) were collected from 19 subjects (10 women, 15 obese) undergoing elective abdominal surgery. The cultured the supernatant was...