A5017636518- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Medical Imaging Techniques and Applications
- Ergonomics and Musculoskeletal Disorders
- Polydiacetylene-based materials and applications
- Food Allergy and Anaphylaxis Research
- Gastrointestinal disorders and treatments
- Appendicitis Diagnosis and Management
- Ocular Disorders and Treatments
- Eosinophilic Esophagitis
- Retinopathy of Prematurity Studies
- Nuclear Physics and Applications
- Hemispheric Asymmetry in Neuroscience
- Pharmacological Effects of Natural Compounds
- Esophageal and GI Pathology
- Fibroblast Growth Factor Research
- Advanced Glycation End Products research
- Metallurgy and Material Science
- Effects of Vibration on Health
- Biopolymer Synthesis and Applications
- Gastroesophageal reflux and treatments
- Infant Health and Development
- Ophthalmology and Visual Impairment Studies
National University of Singapore
2003-2024
Northern Health
2023
Royal Hobart Hospital
2022
Khoo Teck Puat Hospital
2015
National Taipei University
2012
National Yang Ming Chiao Tung University
2012
Singapore National Eye Center
2003-2010
Singapore Eye Research Institute
2003-2007
Roswell Park Comprehensive Cancer Center
2005
University of Calgary
1992-1997
CLEC5A/MDL-1, a member of the myeloid C-type lectin family expressed on macrophages and neutrophils, is critical for dengue virus (DV)-induced hemorrhagic fever shock syndrome in Stat1⁻/⁻ mice ConA-treated wild type mice. However, whether CLEC5A involved pathogenesis viral encephalitis has not yet been investigated. To investigate role to regulate JEV-induced neuroinflammation, antagonistic anti-CLEC5A mAb CLEC5A-deficient were generated. We find that Japanese (JEV) directly interacts with...
Impaired gallbladder motility is an established factor in cholesterol gallstone formation. We assessed whether altered small intestinal smooth muscle contractility with slow transit might potentiate formation by further impeding enterohepatic cycling of bile acids. Ground squirrels were fed a 1% or trace (controls) diet. Small was evaluated from 51Cr distribution conscious, fasted animals 20 minutes after infusion into the proximal jejunum. and determined vitro . Biliary lipid secretion...
Infected Necrotizing Pancreatitis carries a high mortality and necessitates intervention to achieve sepsis control. The surgical strategy for proven infected necrosis has evolved, with abandonment of open necrosectomy step-up approach consisting percutaneous drains Video-assisted retroperitoneal debridement (VARD). We present case that underwent VARD complicated by bleeding colonic perforation describe its management.A 38 year-old male acute pancreatitis developed necrotizing pancreatitis....
The management of patients with locally advanced rectal cancer (LARC) has evolved the aim reducing local recurrence and improving survival. Current practice developed from refinements in surgical technique, availability different types preoperative imaging, selective or blanket use neoadjuvant treatment (usually radiation) sophisticated efforts exploring multimodality treatments to achieve organ preservation. Both short-course radiotherapy (SCPRT) long-course chemoradiation (CRT) are...
Fos immunohistochemistry was used to identify myenteric neurons activated as a consequence of intestinal anaphylaxis in Hooded-Lister rats sensitized egg albumin (EA 10 micrograms ip). After incubation test solutions, or after vivo challenge, jejunal tissues were processed for with an anti-Fos antibody (1:500, TF161). The neuronal identity the Fos-labeled nuclei confirmed by double labeling neuron-specific enclose (1:1,000). In vitro studies, exposure control tissue 50 mM K(+)-Krebs-EA (2 x...
A 58-year old man who was undergoing treatment for an oropharyngeal carcinoma experiencing significant dysphagia and underwent endoscopy placement of a percutaneous endoscopic gastrostomy (PEG) tube. Examination the stomach revealed superficial erosions consistent with mild antral gastritis, double-pylorus deformity identified (Fig. [1]).
The neural modulation of gallbladder filling-emptying and duodenal delivery canine hepatic biliary output was studied in conscious dogs using transient cold blockade or transection the cervical vagosympathetic nerves previously isolated skin loops on either side neck. Gallbladder defined as algebraic difference between a steady-state rate secretion [established by continuous intravenous infusion [14C]taurocholic acid (TCA)] [14C]TCA (measured marker perfusion). Duodenal motility recorded...
Colonic smooth muscle function may be altered in food protein hypersensitivity reactions and could contribute to the clinical manifestation of diarrhea. To characterize such functional changes elucidate mediators mechanisms involved. Hooded-Lister rats were sensitized by intraperitoneal injection egg albumin (10 micrograms), controls sham with saline. Fourteen days later contractility longitudinally oriented distal colonic segments (mucosa intact) studied standard tissue baths response...
Abstract Background The uptake of CYP2C19 testing has been limited, as clinicians opined majority patients with acute coronary syndrome (ACS) undergoing percutaneous interventions (PCI) should receive Ticagrelor per international guidelines. Remaining minority high bleeding risk (HBR) would be on Clopidogrel from the outset. We set out to study how clinicians’ knowledge phenotype affects choice P2Y12 inhibitors, and thus real-world clinical outcomes for ACS patients. report interim findings...
Advances in endovascular technology have expanded the treatment options for intracranial aneurysms. Intrasaccular flow diversion is a relatively new technique that aims to disrupt blood inflow at neck of aneurysm, hence promoting intrasaccular thrombosis. The Woven EndoBridge device (WEB; MicroVention, Aliso Viejo, CA, USA) an US Food and Drug Administration approved diverter wide-necked We report early interim clinical radiological outcomes patients with both ruptured unruptured aneurysms...
To determine whether Yersinia enterocolitica (YE) enteritis has an effect on the biomechanical properties of intestinal smooth muscle, New Zealand White rabbits (600-900 g) were divided into infected group (n = 9) and sham-infected animals fed ad libitum 9), or pair with 9). Animals inoculated 10(10) organisms YE in 10 ml NaHCO3 (infected group) (sham-infected control pair-fed groups) at time 0. Daily food intake, weight gain, excretion noted. Six days later killed longitudinal muscle strips...