A5040077747- RNA modifications and cancer
- Atherosclerosis and Cardiovascular Diseases
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- RNA and protein synthesis mechanisms
- Genomics, phytochemicals, and oxidative stress
- Lung Cancer Research Studies
- Mitochondrial Function and Pathology
- Cancer, Lipids, and Metabolism
- Glycosylation and Glycoproteins Research
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- T-cell and Retrovirus Studies
Goethe University Frankfurt
2025
The University of Texas MD Anderson Cancer Center
2021
Background Citrulline post-translational modification of proteins is mediated by protein arginine deiminase (PADI) family members and has been associated with autoimmune diseases. The role PADI-citrullinome in immune response cancer not evaluated. We hypothesized that PADI-mediated citrullinome a source neoantigens induces response. Methods Protein expression PADI was evaluated 196 cell lines means indepth proteomic profiling. Gene assessed using messenger RNA data sets from Cancer Genome...
Abstract RNA modifications are essential for the regulation of cellular processes and have a key role in diseases such as cancer neurological disorders. A major challenge analysis modification is differentiation between isomers, including methylated nucleosides well uridine pseudouridine. solution their differential chemical reactivity which enables isomer discrimination by mass spectrometry (MS) or sequencing. In this study, we systematically determine hydrazine with its native an...
SUMMARY Selective autophagy of mitochondria is known to promote survival and progression cancer cells in various malignancies including triple-negative breast (TNBC). Here, we aimed identify the essential metabolic adaptations that support mitochondrial quality control with goal uncover actionable vulnerabilities therapeutic potential. Using an integrated approach proteomics untargeted stable-isotope resolved metabolomics, coupled functional experimental analyses, define alternative...
Abstract Nuclear factor erythroid 2-related 2 (NRF2) is aberrantly activated in about 93% of pancreatic cancers. Activated NRF2 regulates multiple downstream molecules involved cancer cell metabolic reprogramming, translational control, and treatment resistance; however, targeting for therapy remains largely unexplored. In this study, we used the online computational tool CellMiner TM to explore NCI-60 drug databases compounds with anticancer activities correlating most closely mRNA...
Small-cell-lung cancer (SCLC) is associated with overexpression of oncogenes including Myc family genes and YAP1 inactivation tumor suppressor genes. We performed in-depth proteomic profiling plasmas collected from 15 individuals newly diagnosed early stage SCLC before the diagnosis compared findings plasma profiles 30 matched controls to determine occurrence signatures that reflect disease pathogenesis. A total 272 proteins were elevated (area under receiver operating characteristic curve...