A5068595028- Pharmaceutical studies and practices
- Food Allergy and Anaphylaxis Research
- Child and Adolescent Health
- Patient Safety and Medication Errors
- Pharmaceutical Practices and Patient Outcomes
- Allergic Rhinitis and Sensitization
- Breastfeeding Practices and Influences
- Asthma and respiratory diseases
- Cardiac Arrest and Resuscitation
- Clinical Nutrition and Gastroenterology
- Celiac Disease Research and Management
- Dental Health and Care Utilization
- Contact Dermatitis and Allergies
- Child Abuse and Trauma
- Infant Nutrition and Health
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Drug-Induced Adverse Reactions
- Infant Health and Development
- Emergency and Acute Care Studies
- Healthcare Systems and Technology
- Poisoning and overdose treatments
- Trauma and Emergency Care Studies
- Child Nutrition and Water Access
- Microscopic Colitis
Noah's Ark Children's Hospital for Wales
2015-2024
Cardiff and Vale University Health Board
2010-2024
University Hospital of Wales
1998-2019
Cardiff University
2004-2015
Boston Children's Hospital
2007-2015
University Hospital Llandough
1993-2014
Bristol Royal Hospital for Children
2013
University of Wales
1999-2002
University of Turin
2002
Wythenshawe Hospital
2002
<h3>Background</h3> The long-term prognosis of Henoch-Schönlein Purpura (HSP) is predominantly determined by the extent renal involvement. There no consensus as to whether treatment with prednisolone at presentation can prevent or ameliorate progression nephropathy in HSP. <h3>Methods</h3> Children under 18 years age new-onset HSP were randomly assigned receive placebo for 14 days. primary outcomes (a) presence proteinuria 12 months (defined urine protein : creatinine ratio (UP UC) >20...
Depending on the duration and severity, psychological tension physical stress can enhance or suppress immune system in both humans animals. Although it is well established that alters release of various hormones neurotransmitters, mechanisms by which affects responses remain elusive. We report here mice subjected to chronic 12-hour daily restraint for two days exhibited a significant reduction splenocytes, process likely mediated apoptosis as demonstrated terminal deoxynucleotidyl...
There has been a growing recognition that coeliac disease is much more common than previously recognised, and this coincided with the increasingly widespread use of serological testing.To determine whether age at presentation clinical have changed advent testing.A 21-year review prospectively recorded data on mode biopsy confirmed in single regional centre. Presenting features over past 5 years were compared those previous 16 years. Between 1983 1989 (inclusive), no testing was undertaken;...
Maternal smoking rates in pregnancy have declined, particularly the non‐manual social classes, and perinatal mortality fallen over last 20 years. We therefore re‐evaluated relationship between maternal cigarette outcome against this background. A total of 608 stillbirths 634 infant deaths were identified using All Wales Perinatal Survey. The cause death was classified clinicopathological system. class groupings compared with those a cohort 16047 survivors born to women resident South...
Abstract Cryptosporidium infection is usually self limited, but can be a life threatening illness in immunocompromised patients. Probiotics have been used successfully the treatment of acute diarrhoea and they also shown to limit parvum animal models. The first case successful resolution prolonged cryptosporidiosis with probiotic reported.
The Brazilian shrub Baccharis megapotamica contains significant amounts of antibiotic trichothecenes. When these plants are grown in the United States, they devoid mycotoxins. Feeding experiments with fungus-produced trichothecenes show that absorbs, translocates, and chemically alters compounds to ones structures analogous those found plant its native habitat. mycotoxins, which have no apparent ill effect megapotamica, kill tomatoes, peppers, artichokes.
Abstract Background Intramuscular epinephrine (adrenaline) is the first‐line therapy for anaphylaxis and prompt administration improves outcome. In 2011, two autoinjectors existed in United Kingdom, differing their users' method: EpiPen ® Anapen . We routinely train all families who receive these devices. Aim To evaluate: Maternal competence using following our standard training package. Which device mothers found easier to use. Methods Mothers with no previous autoinjector experience were...
Introduction Children are at higher risk of medication errors due to the complexity drug prescribing and administration in this patient group. Intravenous (IV) paracetamol overdose differs from by ingestion as there is no enteral absorptive buffering. We provide first national UK data focusing on paediatric IV poisoning. Methods All telephone enquiries National Poisons Information Service between 2008 2021 regarding children less than 18 years old concerning were extracted Database (UKPID)....
Objective To examine if the weight of a child determines adverse events following oral antibiotics prescription. Design Population respective cohort using linked general practice (GP), hospital data and linkage with Welsh Demographic Service for demographic information. Data was performed Wales health data, extracted from SAIL (Secure Anonymised Information Linkage) databank. Inclusion Children (0–12 years) prescribed by their GP in Wales. Exposure Antibiotic prescription (penicillins,...
Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary hypertension, and unknown aetiology. It has seldom been described in association with malignant cytotoxic chemotherapy, there have only two previous reports an Hodgkin's [1, 2]. We report third case which developed 14 yrs after had diagnosed treated, initially radiotherapy subsequently chemotherapy.
Parenteral nutrition (PN) is an essential component of neonatal care for those infants who are unable to tolerate adequate enteral feeding. Its use not without complications such as biochemical derangements, sepsis, thrombosis, extravasation fluid, and death. Such can be reduced by meticulous management PN in response abnormalities, teams, policies reduce staff training more aware pericardial pleural effusions. We ascertained the current practices administration all units with 6 or intensive...
<h3>Background</h3> Prescribing errors complicate a significant number of paediatric admissions. Ongoing training and monitoring prescribing competency in junior doctors has occurred Cardiff since 2001, alongside national measures aimed at improving competency. <h3>Aim</h3> doctors9 to assess the effect these local initiatives. <h3>Methods</h3> Junior receive subsequent assessment on induction. A 1 h bleep-free session concerning precedes completion four tasks. British National Formulary for...
Children with peanut allergy are almost always advised to avoid nuts for life. There have been recent reports from academic centres that in some cases the might resolve and thus these dietary restrictions can be lifted. To evaluate resolution of a selected group children general paediatric setting. 4–16 yr old clear history an allergic reaction peanuts who had not any previous 2 were eligible. Specific immunoglobulin E (IgE) or skin prick test (SPT) at time diagnosis was sought. A SPT...
<h3>Background:</h3> At least 5% of paediatric admissions are complicated by medication error. Nurses can prevent some errors correctly verifying prescriptions before administering drugs, which requires adequate drug calculation skills and familiarity with the BNFc. We wished to explore whether a newly devised chart would improve nurses' dose ability thus potentially reduce doctors' prescription errors. <h3>Aims:</h3> To calculate doses gentamicin for neonates children using new simple...
Recent high-profile medico-legal cases such as the death of Victoria Climbie and subsequent Laming report have highlighted widespread deficiencies in child protection practice. Junior doctors are frontline staff regularly facing issues with potentially major legal implications, including protection, Gillick competence, consent, professional responsibility/accountability. It is therefore important for them to be aware understand Children Act, common principles practices, particularly current,...
<h3>Aims</h3> The Royal College of Paediatrics and Child Health (RCPCH) Science Research Department was commissioned by the to develop national care pathways for children with allergies; food allergy is second pathway. focus on defining competences required improve equity received allergic conditions. <h3>Method</h3> pathway developed a multidisciplinary working group based comprehensive review evidence. reviewed broad stakeholders including public approved Allergy Care Pathways Project...
Objectives To estimate the incidence, characteristics and outcomes of 10-fold or greater a tenth less medication errors in children aged <16 years Wales. Design Population-based surveillance study July 2017 to June 2019. Cases were identified by paediatricians hospital pharmacists using monthly electronic Welsh Paediatric Surveillance Unit (WPSU) reporting system. Patients ‘Definite’ incident occurred when received all any incorrect dose medication. ‘Near miss’ was where prescribed,...
Abstract Optimal nutrition is one of the fundamental components for infants to reach their full growth and neurodevelopmental potential. Best practice facilitated by a contemporaneous, multidisciplinary, evidence‐based policy. Such evidence has recently been reviewed. We have assessed: prevalence policies in neonatal units UK Eire; application hypothetical cases; availability dietetic input; whether any differences existed between non‐regional regional units. A standardized questionnaire was...
Background Intracavity infusion of fibrin sealant-based agents, as a novel modality to control internal bleeding, is associated with an increase pneumoperitoneum (PP) pressure. The safe limit such has not been well defined in hypovolemic subjects. purpose this study was evaluate the hemodynamic and metabolic effects increasing PP pressure define limits carbon dioxide (CO2) insufflation controlled hemorrhage rat model. Methods Ninety male rats (474 ± 6 g, 37° 1°C) were anesthetized,...
Recent research has not only questioned the necessity of iron supplementation in human milk substitutes prior to weaning, but also suggested some potential adverse effects. This study investigated hypothesis that infant formula need contain added first 3 mo. Healthy term infants were recruited into a double-blind controlled trial and randomized receive either new no (New; <0.1 mg Fe 100 ml(-1)) or standard (Standard; 0.5 for mo life. A breastfed reference group was studied. Iron status...