A5086763765- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Neural dynamics and brain function
- Poverty, Education, and Child Welfare
- Vaccine Coverage and Hesitancy
- Neurological disorders and treatments
- Neuroendocrine regulation and behavior
- Infant Development and Preterm Care
- Stress Responses and Cortisol
- Maternal Mental Health During Pregnancy and Postpartum
- Early Childhood Education and Development
- Neuroscience of respiration and sleep
- Tryptophan and brain disorders
- Food Security and Health in Diverse Populations
- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Neuroscience and Music Perception
- EEG and Brain-Computer Interfaces
- Child Nutrition and Water Access
- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Phytochemistry and Biological Activities
- Antioxidant Activity and Oxidative Stress
Universidade Federal do ABC
2010-2025
Inserm
2008-2015
Universidade de São Paulo
1997-2010
Fundação Faculdade de Odontologia
2010
Université Paris Cité
2008
Sorbonne Université
2008
Universidad Nacional de Córdoba
2006
Estácio (Brazil)
2003
Universidade de Ribeirão Preto
1997-2000
St George's Hospital
1999
To assess vaccination coverage, based on the National Immunization Program schedule, among children receiving financial support from Family Income Transfer Program, Brazil, according to family socioeconomic status and maternal characteristics.3,242 under 12 months old were assessed between August/2018 April/2019, of whom 3,008 reassessed September/2019 January/2020. The analyses performed using multilevel models (level 3, Federative Unit; level 2, municipality; 1, children).Vaccination...
Resumo O Programa Criança Feliz (PCF) atinge 1,4 milhão de crianças brasileiras menores três anos com visitas domiciliares visando o desenvolvimento neuropsicomotor. Com base em modelo conceitual, avaliou-se implementação e impacto do PCF estudo randomizado, 30 municípios. Ao todo 3.242 foram alocadas para grupo intervenção (GI) ou controle (GC), sendo 80,0% acompanhadas prospectivamente durante anos. foi avaliado pelo Ages and Stages Questionnaire (ASQ3). Análises por intenção tratar...
Schizophrenic patients show deficits on stimulus salience tasks such as latent inhibition and blocking, which measure the ability to disregard irrelevant stimuli. Amphetamine-treated animals similar in analogous tasks, thereby providing a model of stimulus-selection observed schizophrenia. In two experiments, effect indirect dopamine (DA) agonist D-amphetamine sulphate (1.0 mg/kg, i.p.) Kamin blocking overshadowing were examined compared, rat, using conditioned lick suppression procedure....
Prepulse inhibition (PPI) is a behavioral test in which the startle reflex response to high-intensity stimulus (pulse) inhibited by prior presentation of weak (prepulse). The classic neural circuitry that mediates localized brainstem; however, recent studies point contribution structures involved higher cognitive functions regulating sensorimotor gating, particularly forebrain regions innervated dopaminergic nuclei. aim present study was verify role dorsal striatum (DS) and transmitting...
Abstract l ‐DOPA is still the drug of choice to treat Parkinson’s disease although adverse side effects appear after several years treatment. These are thought be consequence plastic re‐arrangements nigrostriatal connections, such as sprouting dopaminergic terminals or post‐synaptic changes. Pleiotrophin, a trophic factor that we have shown up‐regulated in striatum parkinsonian rats long‐term treatment may play role these To determine whether one three known pleiotrophin receptors [ N...
Background: Altered sensorimotor gating has been demonstrated by Prepulse Inhibition (PPI) tests in patients with psychosis. Recent advances signal processing methods allow assessment of neural PPI through electroencephalogram (EEG) recording during acoustic startle response measures (classic muscular PPI). Simultaneous measurements (eye-blink) and phenomena test may help to better understand sensorial dysfunctions In this study, we aimed assess simultaneously early bipolar disorder...
Abstract The Happy Child Program (Programa Criança Feliz - PCF, in Portuguese) reaches 1.4 million Brazilian children under three years of age with home visits aimed at promoting neuropsychomotor development. Based on a conceptual model, PCF implementation and impact were evaluated randomized study 30 municipalities. A total 3,242 allocated to the intervention (IG) or control (CG) group, 80.0% whom prospectively followed up from late 2018 2021. Development was assessed by Ages Stages...
Prepulse inhibition (PPI) test has been widely used to evaluate sensorimotor gating. In humans, deficits in this mechanism are measured through the orbicularis muscle response using electromyography (EMG). Although can be modulated by several brain structures and is impaired some pathologies as schizophrenia bipolar disorder, neural PPI evaluation rarely performed humans. Since eye blinks a side effect of stimulation, they strongly contaminate electroencephalogram (EEG) signal. This paper...
Abstract Background We tested the hypothesis that children of non-depressed mothers perform better in a developmental test at 3 years than depressed mothers. Method Longitudinal analysis from trial to assess impact child development promotion program 30 Brazilian municipalities. Mothers and were appraised first-year post-partum, 1 after enrollment. Child was assessed through Ages Stages Questionnaire (ASQ3) maternal depression Edinburgh Postnatal Depression Scale (EPDS). Crude adjusted beta...
Systemic injection of the nitric oxide (NO) synthase inhibitor N(G)-nitro-L-arginine (LNO) prevents disruptive effect amphetamine (Amph) on prepulse inhibition (PPI), a sensorimotor gating model in which amplitude acoustic startle response (ASR) to startling sound (pulse) is reduced when preceded immediately by weaker stimulus (prepulse). Given that dopamine (DA) projections basolateral amygdala (BLA) are involved control information processing, our aim was investigate if intra-BLA...
The disruption of neurodevelopment is a hypothesis for the emergence schizophrenia. Some evidence supports that redox imbalance could account developmental impairments associated with Additionally, there deficit in glutathione (GSH), main antioxidant, this disorder. injection metilazoximetanol acetate (MAM) on 17th day gestation Wistar rats recapitulates neurodevelopmental and oxidative stress offspring exposed to MAM treatment present early adulthood behavioral neurochemical deficits...
Modelos experimentais baseados no aumento da neurotransmissão dopaminérgica mimetizam aspectos comportamentais e neuroquímicos característicos esquizofrenia. Psicoestimulantes, como a anfetamina, são utilizados com esta finalidade, pois aumentam os níveis de dopamina extracelular nas vias mesocorticolímbica mesoestriatal. As limitações manipulação direta do sistema dopaminérgico nos modelos animais incentivam abordagens complementares. O óxido nítrico (NO), um neurotransmissor atípico que...
Prepulse inhibition (PPI) consists of a reduction the acoustic startle reflex (SR) magnitude (measured with EMG) when startling stimulus is preceded by non-startling one. This behavior has been extensively investigated in studies related to schizophrenia, since sensory-motor deficit plays central role its pathophysiology. However, same auditory stimuli that trigger SR also provoke intense evoked responses (AEP), which can be measured EEG. Comparing these two types responses, acquired...