A5028821682- Bipolar Disorder and Treatment
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Electrolyte and hormonal disorders
- Neuroscience of respiration and sleep
- Genetic Syndromes and Imprinting
- Advanced MRI Techniques and Applications
- Epilepsy research and treatment
- Fetal and Pediatric Neurological Disorders
- Mental Health Research Topics
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Schizophrenia research and treatment
- Advanced NMR Techniques and Applications
- Vestibular and auditory disorders
- Sleep and Wakefulness Research
- Suicide and Self-Harm Studies
- Neonatal and fetal brain pathology
- Ion Transport and Channel Regulation
- Circadian rhythm and melatonin
- Child and Adolescent Psychosocial and Emotional Development
University of Iowa
2022-2024
BACKGROUNDSeizure-induced inhibition of respiration plays a critical role in sudden unexpected death epilepsy (SUDEP). However, the mechanisms underlying seizure-induced central apnea pediatric are unknown.METHODSWe studied 8 patients with intractable undergoing intracranial electroencephalography. We recorded during seizures and electrical stimulation mapping 174 forebrain sites. A machine-learning algorithm was used to delineate brain regions that inhibit respiration.RESULTSIn 2 patients,...
Postictal apnea is thought to be a major cause of sudden unexpected death in epilepsy (SUDEP). However, the mechanisms underlying postictal are unknown. To understand causes apnea, we used multimodal approach study brain breathing control 20 patients (ranging from pediatric adult) undergoing intracranial electroencephalography for intractable epilepsy. Our results indicate that amygdala seizures can apnea. Moreover, identified distinct region within where electrical stimulation was...
Purpose Studies of the neural underpinnings bipolar type I disorder have focused on emotional control network. However, there is also growing evidence for cerebellar involvement, including abnormal structure, function, and metabolism. Here, we sought to assess functional connectivity vermis with cerebrum in whether might depend mood. Methods This cross-sectional study enrolled 128 participants 83 comparison who completed a 3 T magnetic resonance imaging (MRI) study, which included anatomical...
Studies of the neural underpinnings bipolar type I disorder have focused on emotional control network. However, there is also growing evidence for cerebellar involvement, including abnormal structure, function, and metabolism. Here, we sought to assess functional connectivity cerebellum with cerebrum in whether any effects might depend mood.This cross-sectional study enrolled 128 participants 83 comparison who completed a 3T MRI scan, which included anatomical imaging as well resting state...
Abstract Introduction Functional decline in the hippocampus is a prominent neurodegenerative feature of Alzheimer’s Disease and related dementias. Alterations circadian rhythms can exacerbate cognitive aging neurodegeneration. This study examined how dim light melatonin onset (DLMO) associated with resting state functional connectivity three cortical regions (i.e., prefrontal, temporal, posterior cingulate). Methods We studied data from 52 later-life adults (mean age =70.0 SD= 6.3)....
This study used resting state functional connectivity to of the cerebellar vermis with cerebrum in bipolar disorder.
Bipolar disorder is a serious psychiatric condition whose cause remains unknown. Previous diffusion MRI studies suggest white matter alterations may be involved, but standard tensor scalars provide limited information regarding potential pathophysiology. Here we used Neurite Orientation Dispersion and Density Imaging (NODDI) to examine select bundles additional changes in microstructure. We found that the uncinate fasciculus, cingulum hippocampus, corpus callosum genu showed evidence of...
Abstract Background The neural underpinnings of bipolar disorder (BD) remain poorly understood. cerebellum is ideally positioned to modulate emotional regulation circuitry yet has been understudied in BD. Previous studies have suggested differences cerebellar activity and metabolism BD, however findings on structural contradictory. Methods We collected 3T anatomical MRI scans from participants with (N = 131) without 81) BD type I. Differences volumes were assessed along factors that...
This study used 31P and 1H MRS to brain metabolic differences in bipolar disorder. Data from 64 participants with BD 42 controls was acquired the right putamen cerebellar vermis were at 7T. The observed reduced pHi support of prior work that has proposed mitochondrial dysfunction where there is an impaired ability utilize pyruvate oxidative phosphorylation. A shift phosphorylation toward glycolytic energy production likely increases lactate acid, CO2 levels, free protons resulting tissue...