A5069613156- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Pharmaceutical studies and practices
- Adolescent and Pediatric Healthcare
- Celiac Disease Research and Management
- Autoimmune and Inflammatory Disorders Research
- Child Nutrition and Feeding Issues
- Pregnancy and Medication Impact
- Pediatric Pain Management Techniques
- Breastfeeding Practices and Influences
- Immunodeficiency and Autoimmune Disorders
- Gastroesophageal reflux and treatments
- Childhood Cancer Survivors' Quality of Life
- Helicobacter pylori-related gastroenterology studies
- Digestive system and related health
- Gastrointestinal motility and disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Intestinal and Peritoneal Adhesions
- Pancreatitis Pathology and Treatment
- Intestinal Malrotation and Obstruction Disorders
- Liver Diseases and Immunity
- Circadian rhythm and melatonin
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Viral gastroenteritis research and epidemiology
Tel Aviv University
2016-2025
Tel Aviv Sourasky Medical Center
2014-2025
Schneider Children's Medical Center
2019-2024
Chang Gung Children's Hospital
2017
Assistance Publique – Hôpitaux de Paris
2015
Université Paris-Sud
2015
The pharmacokinetics of biologic agents can differ between children and adults with inflammatory bowel disease (IBD), often necessitating modified paediatric dosing strategies. To define the exposure-response relationship vedolizumab in IBD VedoKids cohort including effect baseline clearance on deep biochemical remission (normal C-reactive protein [CRP]/erythrocyte sedimentation rate [ESR] steroid-free remission) at 30 weeks, to use population pharmacokinetic models find best matches adult...
Abstract Background Tasty&HealthyTM (T&H) is a whole food diet aimed at alleviating inflammation in Crohn’s disease (CD). It excludes processed food, gluten, red meat, and dairy (except for plain yogurt), but does not include mandatory ingredients or partial enteral nutrition with formula as the CD Exclusion Diet. In this RCT we evaluated T&H an intervention persistent subclinical compared continuing habitual diet. (NCT#04239248; TASTI-E). Methods Patients CD, aged 6-40 years,...
There are scarce data available on upadacitinib in children with Crohn's disease (CD). To evaluate the effectiveness and safety of as an induction therapy paediatric CD. This was a multicentre retrospective study between 2022 2024 treated for remission active CD conducted 30 centres worldwide affiliated IBD Interest Porto group ESPGHAN. We recorded demographic, clinical laboratory adverse events (AEs) at week 8 post-induction. The analysis primary outcome based upon intention-to-treat (ITT)...
Current data on ustekinumab therapy in children with ulcerative colitis (UC) or unclassified inflammatory bowel disease (IBDU) are limited. We aimed to evaluate the effectiveness and safety of pediatric UC IBDU.
Neutrophil extracellular traps (NETs) are fibers composed of chromatin and neutrophil proteins released by activated neutrophils. NETs trap kill microbes, activate dendritic T cells, implicated in autoimmune vascular diseases. The pathogenesis inflammatory bowel disease (IBD) is multifactorial characterized chronic active mucosal inflammation with controversial contribution Our aim to describe the involvement pediatric IBD. We retrospectively examined biopsies from small colon children at...
ABSTRACT Objectives: Inflammatory bowel disease (IBD) has a high impact on nutritional status. Sarcopenia is related to higher risk of surgery and rescue therapy in adults with IBD; however, comparable data pediatric populations are scarce. We evaluated muscle mass as predictor outcome IBD. Methods: All IBD patients who underwent magnetic resonance enterography (MRE) during 2008 2019 were included. Muscle was assessed by measuring the area psoas at upper level L3 MRE. The divided body...
Objectives: Escalation of the ustekinumab (UST) maintenance dosage was effective in adults with Crohn disease (CD), but no data are available for children. We evaluated effectiveness and safety dose escalation UST pediatric CD. Methods: This a retrospective multicenter study from 25 centers affiliated IBD Interest Porto groups ESPGHAN. included children CD who initiated at standard dosing underwent either to intervals shorter than 8 weeks or re-induction due active disease. Demographic,...
There is no model for the process of transition adolescents with inflammatory bowel diseases (IBD) to adult care protocol. We recently established a clinic where 17-year-old 18-year-old IBD patients are seen by multidisciplinary team including pediatric and gastroenterologists expertise in treatments, an nurse, psychologist. quantitatively describe this its benefits, correlate demographic parameters self-efficacy adolescent before after transition.All enrolled our between January 2013...
Abstract Background Functional abdominal pain (FAP) disorders are one of the most common gastrointestinal in children. We aimed to define association between obesity and functional assess differences overweight/obese children normal weight with FAP disorders. Methods conducted a retrospective study (2–18 years old) clinical diagnosis who were followed-up our pediatric gastroenterology unit 1/2016–10/2018. defined according ROME IV criteria. Body mass index (BMI) percentiles by CDC standards....
Abstract Background The Tasty&Healthy™ (T&H) diet offers a flexible alternative to exclusive enteral nutrition (EEN) for inducing remission in Crohn’s disease (CD). Unlike CDED, it excludes processed foods, gluten, red meat, and most dairy but does not rely on formula or mandatory ingredients. "MyTasty" trial aimed assess the effectiveness feasibility of T&H maintaining children adults with CD, gradual reintroduction gluten Methods Patients CD (4-37 years age) who entered deep...
Abstract Background Recent advances in inflammatory bowel disease (IBD) therapies have provided patients with a variety of medications different routes administration. We aimed to assess parental preferences regarding medication administration and identify factors influencing these Methods This cross-sectional study surveyed parents children IBD using comprehensive questionnaire that focused on treatment experiences, preferences, attitudes towards switching from intravenous (IV) subcutaneous...
Abstract Background Loss of response (LOR) to first biologic agent is not uncommon. One the most challenging mechanisms LOR pharmacodynamic (inflammatory activity in presence adequate trough concentrations, TC). We aimed explore outcomes pediatric patients with Crohn’s disease following adalimumab failure. Methods conducted a retrospective longitudinal cohort study 6 Israeli centers. Data who experienced (as agent) TC (>7.5 mcg/ml) and switched either infliximab or ustekinumab were...
Abstract Background Data on upadacitinib therapy in children with ulcerative colitis (UC) or unclassified inflammatory bowel disease (IBD-U) are scarce. We aimed to evaluate the effectiveness and safety of as an induction pediatric UC IBD-U. Methods In this multicenter retrospective study, treated for remission active IBD-U from 30 centers worldwide were enrolled. Demographic, clinical laboratory data well adverse events (AEs) recorded at week 8 post induction. Results One hundred included...
Abstract Background Data on upadacitinib therapy in children with Crohn’s disease (CD) are scarce. We aimed to evaluate the effectiveness and safety of as an induction pediatric CD. Methods A multicenter retrospective study treated for remission active CD from 30 centers worldwide affiliated IBD Interest Porto group ESPGHAN between 2022 2024. Demographic, clinical, laboratory, imaging data well adverse events (AEs) were recorded at week 8 post induction. The analysis primary outcome was...
ABSTRACT Aim The adherence to a gluten‐free diet ( GFD ) in celiac disease CD is influenced by socioeconomic factors and language barriers, which are especially relevant minority populations. study aimed compare outcomes children of Eritrean asylum seekers living Israel those native Israeli children. Methods This retrospective case–control included demographic, clinical, laboratory, endoscopic, histologic data all diagnosed with during 2015–2023. For each child, 5 consecutive served as...
The role of hepcidin in inflammatory bowel disease [IBD] children with anaemia is poorly understood. However, it has been shown that vitamin D suppresses expression. We aimed to assess serum levels and the effect treatment on those newly diagnosed IBD paediatric patients.Eighty-five were prospectively recruited Dana-Dwek Children's Hospital [40 IBD, 45 healthy controls, 47% female, mean age 13.5 ± 3.4 years]. Blood samples for measurement interleukin 6 [IL-6], C-reactive protein [CRP],...
Abstract Background Non-alcoholic fatty liver disease (NAFLD) can range from simple steatosis to steatohepatitis with or without fibrosis. The predictors for fibrosis and the effect of nutritional intervention on hepatic in pediatric population are not well established. We aimed investigate effects short-term among obese adolescents NAFLD. Methods Cross-sectional study adolescents. Sociodemographic clinical data were collected. Liver was estimated by Shearwave elastography. All participants...
This study described disease characteristics and long-term outcomes in patients diagnosed with very early onset inflammatory bowel (VEOIBD) (diagnosed before 6 years of age) infantile-IBD (before 2 years).
Summary Background Incidence rate and temporal trends in coeliac disease autoimmunity incidence vary worldwide with most data available from North American European countries. Aims To explore of their relation to increase screening tests Israel. Methods A large retrospective population‐based study was conducted Maccabi Healthcare Services, a 2.3‐million‐member health maintenance organisation operating The cohort included all patients newly diagnosed based on first positive anti‐tissue...
Objectives: Inflammatory bowel disease (IBD) has been historically associated with underweight and malnutrition. The impact of both obesity on the clinical course IBD in adults is controversial. This study described association between body mass index (BMI) at diagnosis to children IBD.Methods: We reviewed medical records from database 'Dana-Dwek' Children's Hospital 2010 2016. Demographic anthropometric data were collected as characteristics, therapy. Patients categorized quartiles...