A5047661429- Marine Ecology and Invasive Species
- Marine Invertebrate Physiology and Ecology
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Planarian Biology and Electrostimulation
- Environmental Toxicology and Ecotoxicology
- Advanced MRI Techniques and Applications
- Parasite Biology and Host Interactions
- Cancer, Lipids, and Metabolism
- Prostate Cancer Diagnosis and Treatment
- Heavy Metal Exposure and Toxicity
- Cancer-related gene regulation
- Prostate Cancer Treatment and Research
- Parasites and Host Interactions
Universität Innsbruck
2021-2025
Innsbruck Medical University
2024-2025
Abstract β-Catenin has two major functions conserved across metazoans. It enables the interaction of classical cadherin with actin and it is main transcription factor activated by canonical Wnt pathway. In these functions, acts in patterning body axis early embroys, cell differentiation proliferation. flatworms, four β-catenin homologs have been identified planarian Schmidtea mediterranea. Functional studies revealed that only Smed-β-catenin1 can transduce signal plays a part defining...
Earthworms are well-established model organisms for testing the effects of heavy metal pollution. How DNA methylation affects cadmium (Cd) detoxification processes such as expression metallothionein 2 (MT2), however, is largely unknown. We therefore exposed Lumbricus terrestris to 200 mg concentrations Cd and 5-aza-2′-deoxycytidine (Aza), a demethylating agent, sampled tissue coelomocytes, cells innate immune system, 48 h. MT2 transcription significantly increased in Cd- Cd-Aza-treated...
Despite clinical suspicion of prostate cancer (PCa), 20-25% patients exhibit a tumor-negative biopsy result.
<title>Abstract</title> β-Catenin has two major functions conserved across metazoans. It enables the interaction of classical cadherin with actin at apical junctional complexes and it is main transcription factor activated by canonical Wnt pathway. In these functions, acts in cell differentiation, proliferation, determining body axis early embryos. 4 β-catenin homologs have been described highly regenerating planarian flatworm <italic>Schmidtea mediterranea</italic>. Among them, only...
Earthworms are affected by physical stress, like injury, and exposure to xenobiotics, such as the toxic metal cadmium (Cd), which enters environment mainly through industry agriculture. The stress response single combination of both stressors was examined in regenerative unharmed tissue Lumbricus terrestris reveal if a natural insult injury (amputation) interferes with Cd detoxification mechanisms. We characterized roles metallothionein 1 (MT1) MT2 isoforms, heat shock protein 70 well immune...