<h3>Background</h3> Inhaled corticosteroid (ICS) use could decrease local immunity of the lung. Concerns have been raised regarding risk tuberculosis (TB) development among ICS users. The aim this study was to elucidate association between and TB patients with various respiratory diseases in South Korea, an intermediate-TB-burden country. <h3>Methods</h3> A nested case-control based on Korean national claims database performed. eligible cohort consisted 853 439 new adult users inhaled...

Background/Aims We evaluated the prevalence and characteristics of thyroid nodules detected by ultrasound (US) at health checkups associated clinical parameters. Methods A total 72,319 subjects who underwent US three checkup centers in Korea from January 2004 to December 2010 were included this study. The correlations between presence other parameters analyzed. Results cysts was 34.2% (n = 24,757). Thyroid more prevalent women older age groups. Among with size information 24,686), 18,833...

A system that combines technology and web-based coaching can help treat chronic conditions such as diabetes. However, the effectiveness of apps in mobile health (mHealth) interventions is inconclusive unclear due to heterogeneous varying follow-up durations. In addition, randomized controlled trial data are limited, long-term lacking, especially for integrated into electronic medical records.We aimed assess effect an record-integrated app personalized diabetes self-care, focusing on...

BackgroundCCL2/C–C chemokine receptor 2 (CCR2) signalling is suggested to play a significant role in various kidney diseases including diabetic nephropathy. We investigated the renoprotective effect of CCR2 antagonist, RS102895, on development nephropathy type mouse model.

Objective: The suicide rate in South Korea was the highest among Organisation for Economic Co-operation and Development (OECD) countries 2011. Although adolescents is lower than that of adults reported to be decreasing young males some countries, it has consistently increased recent years Korea. We aimed determine prevalence, pattern, predictors suicidal ideation attempt past 12 months. Methods: A total sample 72,623 aged 12–18 who responded a web-based anonymous self-reported survey between...

This study was conducted to analyze the association between digestive symptoms and sleep disturbance, determine if any are related disturbance. a cross-sectional of 5792 subjects surveyed in community-based cohort. Subjects provided information regarding quality as assessed by Pittsburgh Sleep Quality Index (PSQI), well Gastrointestinal Symptom Rating Scale (GSRS). Logistic regressions were used examine factors associated with quality. The mean PSQI global score no disturbances group (n =...

Background: Current research has not investigated the effect of thyroid-stimulating hormone suppression therapy with levothyroxine on risk for developing subsequent primary cancers (SPCs). This study aimed to investigate association between dosage and SPCs in thyroid cancer patients.Methods: We conducted a nationwide population-based retrospective cohort form Korean National Health Insurance database. included 342,920 patients 2004 2018. Patients were divided into non-levothyroxine groups,...

The authors investigated the rupture rate among patients with untreated unruptured intracranial aneurysms (UIAs) in South Korea during 2006-2009.A longitudinal study using national representative health-claim data, including all hospital records for every Korean citizen, was used. Patients a UIA who were 18-80 years old 2006 identified I67.1 ICD-10 code. To select eligible patients, historical period of 1 year prior to first diagnosis utilized. previous diagnosis, subarachnoid hemorrhage...

Tyrosinase is a key enzyme in melanin synthesis, catalyzing the initial rate-limiting steps of synthesis. Abnormal and excessive synthesis primary cause serious skin disorders including melasma, senile lentigo, freckles, age spots. In attempts to find potent safe tyrosinase inhibitors, we designed synthesized novel compound, (Z)-3-(3-bromo-4-hydroxybenzylidene)thiochroman-4-one (MHY1498), evaluated its inhibitory activity vitro silico. The chemical structures...

More than half of the patients have reported improper management breakthrough cancer pain. Empirical evidence is lacking concerning effectiveness pain education on control. This study aimed to examine effects individual control, use short-acting analgesics for pain, quality life outcomes, and rectification patients' misconceptions regarding pain.A quasi-experimental design was used. In total, 176 (102 inpatients 74 outpatients) 163 (93 70 completed questionnaires intensity, life, medication...

Usual source of care (USC) is one the hallmarks primary care. We aimed to examine status having a USC and its patient-related sociodemographic factors among Korean adults.Data were obtained from 2012 Korea Health Panel survey. participants selected for study who aged 18 years or older replied questionnaire items on (n = 11,935).Of participants, 21.5% had usual place 13.9% physician. Reasons not seldom being ill (66.1%), preference visit multiple medical institutions (27.9%), others. The...

BackgroundPeroxisome proliferator-activated receptor (PPAR)-δ is a ligand-activated transcription factor in regulating gene expression and believed to play an important role various kidney diseases including diabetic nephropathy. This study investigated the efficacy of GW610742, highly specific agonist for PPAR-δ, treatment

Abstract Background The outcomes of education and counseling by medical professionals for patients with type 2 diabetes mellitus (T2DM) are unclear. This study examined the effects Chronic Disease Management Program (CDMP), a health insurance fee-for-service benefit, on incidence diabetic complications in newly diagnosed T2DM using National Health Insurance data. Methods Patients aged ≥ 20 years from 2010 to 2014 were followed up until 2015. Selection bias was minimized propensity score...

Aim: To investigate factors that affect the place of death (POD) terminal cancer patients. Materials and Methods: We recruited 702 consecutive patients (<TEX>${\geq}18$</TEX> years) from 12 centers during July 2005 to October 2006, 481 completed questionnaire. In April 2011, we linked data for 96.0% (n=462) deceased POD using 2005-2009 certificate Korea's National Statistical Office. The primary outcome variable was POD, predictive value variables pertaining caregivers evaluated univariate...

Aging is associated with increased fat mass and elevated serum leptin levels (hyperleptinemia), causing proinflammation in the kidneys where it plays a primary role removal of endogenous from circulation. Lymphocyte-specific kinase (Lck) positive regulator inflammatory signaling potential treatment target for age-related diseases, but its unknown. Here, we investigated how Lck influences hyperleptinemia-induced inflammation kidney tissues 6- 21-month-old rats. Results indicate that...

(1) Objective: This study examined the incidence and risk factors contributing to progression diabetes mellitus (DM) in a seven-year follow-up of non-diabetic National Health Examinees. (2) Methods: For this retrospective observational cohort study, we used two national representative databases: Screening (HEALS) database 2009 Insurance Service (NHIS) 2009–2015. The eligible subjects without DM with blood sugar levels &lt;126 mg/dL were selected using HEALS database. subsequent clinical...

This study investigated the effectiveness of an integrative medicine program (IMP) for dementia prevention on cognitive function, depression and quality life (QOL) elderly in a public health center.This employed before-after design to assess IMP community dwelling over 60 without diagnosis dementia. Cognitive function was measured using Mini Mental State Examination Dementia screening (MMSE-DS), digit span test (DST) trail making (TMT). The Geriatric Depression Scale Short Form- Korean...

This retrospective cohort study was done to investigate the incidence of hypertension and its relation fasting blood glucose level in Korea. The eligible non-hypertensive subjects (n = 3,396,187) among National Health Insurance Service-National Screening (NHIS-HEALS) examinees 10,644,911) 2009 were followed up until 2015. A Cox proportional hazards regression used estimate risk high for incident while controlling covariates’ confounding effect. cumulative rate 10.6% seven years (11.6% men...