A5047765476- Stroke Rehabilitation and Recovery
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Neuroscience and Neuropharmacology Research
- Thermal Regulation in Medicine
- Neurological Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Anesthesia and Neurotoxicity Research
- Neurogenesis and neuroplasticity mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Transcranial Magnetic Stimulation Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal and fetal brain pathology
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disorders and Treatments
- Cerebral Palsy and Movement Disorders
- Neural dynamics and brain function
- Nerve injury and regeneration
- Olfactory and Sensory Function Studies
- Cardiac Ischemia and Reperfusion
- Dementia and Cognitive Impairment Research
- Thermoregulation and physiological responses
- Advanced MRI Techniques and Applications
- Diet and metabolism studies
- Adipose Tissue and Metabolism
University of Ottawa
2015-2025
Ottawa Hospital
2017-2023
Ottawa Hospital Research Institute
2018-2023
Ottawa University
2023
Florey Institute of Neuroscience and Mental Health
2023
The University of Melbourne
2023
Heart and Stroke Foundation
2013-2022
Ontario Brain Institute
2021
uOttawa Brain and Mind Research Institute
2018-2021
Memorial University of Newfoundland
2008-2017
The first Stroke Recovery and Rehabilitation Roundtable established a game changing set of new standards for stroke recovery research. Common language definitions were required to develop an agreed framework spanning the four working groups: translation basic science, biomarkers recovery, measurement in clinical trials intervention development reporting. This paper outlines by our group vision accelerating progress
To maximize the effectiveness of rehabilitative therapies after stroke, it is critical to determine when brain most responsive (i.e., plastic) sensorimotor experience injury and focus such efforts within this period. Here, we compared efficacy 5 weeks enriched rehabilitation (ER) initiated at d (ER5), ER14, or ER30 focal ischemia, as judged by functional outcome neuromorphological change. ER5 provided marked improvement in skilled forelimb reaching ability ladder-rung- narrow-beam-walking...
Chronic impairment of forelimb and digit movement is a common problem after stroke that resistant to therapy. Previous studies have demonstrated enrichment improves behavioral outcome focal ischemia; however, postischemic alone not capable enhancing fine function. Therefore, we combined environmental with daily skilled-reach training assess the effect intensive task-specific rehabilitation on long-term functional outcome. Rats were subjected either endothelin-1-induced ischemia or sham...
Animal models suggest that a month of heightened plasticity occurs in the brain after stroke, accompanied by most recovery from impairment. This period peri-infarct and remote is associated with changes excitatory/inhibitory balance spatial extent activation cortical maps structural remodeling. The best time for experience training to improve outcome unclear. In animal models, very early (<5 days onset) intense may lead increased histological damage. Conversely, late rehabilitation...
In the gerbil, brief global forebrain ischemia induces profound habituation and working memory impairments that stem from delayed hippocampal CA1 death. Short duration postischemic hypothermia has been shown to reduce loss, but such reports are controversial, as it is thought protection may be transient. The purpose of this study was investigate whether prolonged provided long-term functional neuroprotection. Previously, 90% anterior neurons were rescued (30 d survival) when 24 hr (32...
Background and Purpose— Brain-derived neurotrophic factor (BDNF) is involved in neuronal survival, synaptic plasticity, learning memory, neuroplasticity. Further, exogenous treatment with BDNF or exposing animals to enrichment exercise regimens, which also increase BDNF, enhances behavioral recovery after brain injury. Thus, the beneficial effects of rehabilitation promoting stroke may depend on BDNF. We tested this hypothesis by evaluating contribution motor skill relearning...
The first Stroke Recovery and Rehabilitation Roundtable established a game changing set of new standards for stroke recovery research. Common language definitions were required to develop an agreed framework spanning the four working groups: translation basic science, biomarkers recovery, measurement in clinical trials intervention development reporting. This paper outlines by our group vision accelerating progress
Background and Purpose— Previous estimates of the number prevalence individuals experiencing effects stroke in Canada are out date exclude critical population groups. It is essential to have complete data that report on disability for monitoring planning purposes. The objective was provide an updated estimate (and its regions), trending since 2000 forecasted 2038. Methods— prevalence, trends, projected were estimated using region-specific survey adjusted account children aged <12 years...
Abstract Intracerebral hemorrhage (ICH) is characterized by parenchymal hematoma formation with surrounding inflammation. Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of neurological diseases defined inflammation and cell death. To investigate expression profile pathogenic aspects MMPs ICH, we examined MMP vivo using a collagenase‐induced rat model ICH. ICH increased brain MMP‐2, ‐3, ‐7, ‐9 mRNA levels relative to sham‐injected (control) animals vicinity...
Delayed but prolonged hypothermia persistently decreases cell death and functional deficits after global cerebral ischemia in rodents. Postischemic also reduces infarction middle artery occlusion (MCAO) rat. Because initial neuroprotection is sometimes transient may not subserve recovery, especially on demanding tasks, the authors examined whether postischemic cooling would reduce forelimb reaching MCAO. Male spontaneously hypertensive rats were trained to retrieve food pellets a staircase...
Abstract Cortical stem cell transplantation may help replace lost brain cells after stroke and improve the functional outcome. In this study, we transplanted human embryonic (hESC)‐derived neural precursor (hNPCs) or vehicle into cortex of rats permanent distal middle cerebral artery occlusion (dMCAO) sham‐operation, followed recovery in cylinder staircase tests. The hNPCs were examined prior to transplantation, they expressed neuroectodermal markers but not for undifferentiated hESCs...
Abstract In many recovering hemiparetic stroke patients, movement of the affected limb elicits ipsilateral activation sensorimotor areas within undamaged hemisphere, which is not observed in control subjects. Following middle cerebral artery occlusion, rats received intensive enriched‐rehabilitation (ER) impaired forelimb for 4 weeks. Weekly assessments on a skilled reaching test demonstrated significant improvement ischemic animals over weeks ER ( P < 0.05). We hypothesized that if motor...
Rats lever pressed for concurrent electrical stimulation of the lateral hypothalamus and ventral tegmentum. The pulse-pair technique was used, with first pulse each pair applied to one electrode second other electrode; intrapair interval varied. effectiveness stimulation, measured behaviorally, increased abruptly (within .4 msec) as in range from 1.0 2.0 msec. These results, which do not resemble single-electrode refractory period are interpreted evidence collision directly stimulated,...
Stroke recovery is the next frontier in stroke medicine. While growth rehabilitation and research exponential, a number of barriers hamper our ability to rapidly progress field. Standardized terminology absent both animal human research, methods are poorly described, biomarkers not well defined, we lack consistent timeframes or measures examine outcomes. Agreed conventions for developing, monitoring, evaluating reporting interventions directed at improving lacking, current approaches often...