A5056049358- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Monoclonal and Polyclonal Antibodies Research
- Venous Thromboembolism Diagnosis and Management
- Cancer Mechanisms and Therapy
- Cancer Treatment and Pharmacology
- Immunotherapy and Immune Responses
- Animal Virus Infections Studies
- MicroRNA in disease regulation
- Palliative Care and End-of-Life Issues
- Immune Cell Function and Interaction
- Molecular Biology Techniques and Applications
- T-cell and B-cell Immunology
- Gene expression and cancer classification
- Cancer survivorship and care
- Prostate Cancer Treatment and Research
- Advanced Biosensing Techniques and Applications
- Chemotherapy-related skin toxicity
- Frailty in Older Adults
- Central Venous Catheters and Hemodialysis
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Microtubule and mitosis dynamics
- Immunotoxicology and immune responses
North Shore University Hospital
2004-2024
Northwell Health
2009-2024
Long Island Jewish Medical Center
2015-2024
University of Edinburgh
2024
University of Cambridge
2021-2023
Cancer Research UK
2021-2023
Cancer Research UK Cambridge Center
2023
West Virginia University
2021
University of East Anglia
2017-2020
Norwich Research Park
2019-2020
Oncogene amplification has been observed in a broad spectrum of human tumors and associated with poor prognosis for patients several different types malignancies. Importantly, at biopsy, the amplified genes localize to acentric extrachromosomal elements such as double-minute chromosomes (DMs) vast majority cases. We show here that treatment tumor cell lines low concentrations hydroxyurea accelerates loss their extrachromosomally oncogenes. The decreases MYC copy number line correlated...
Abstract The drivers of recurrence and resistance in ovarian high grade serous carcinoma remain unclear. We investigate the acquisition by collecting tumour biopsies from a cohort 276 women with relapsed BriTROC-1 study. Panel sequencing shows close concordance between diagnosis relapse, only four discordant cases. There is also very strong copy number no significant difference purity, ploidy or focal somatic alterations, even when stratified platinum sensitivity prior chemotherapy lines....
Abstract Purpose: Ovarian high-grade serous carcinoma (HGSC) is usually diagnosed at late stage. We investigated whether late-stage HGSC has unique genomic characteristics consistent with acquisition of evolutionary advantage compared early-stage tumors. Experimental Design: performed targeted next-generation sequencing and shallow whole-genome (sWGS) on pretreatment samples from 43 patients FIGO stage I–IIA to investigate somatic mutations copy-number (CN) alterations (SCNA). results 52...
Hypersensitivity is a well-known complication of the platinum agents cisplatin and carboplatin. Although hypersensitivity to oxaliplatin has been noted, incidence varies significantly in reports. Risk factors for developing reactions specifically have not evaluated. We report 5-year our clinical program, patient disease characteristics associated with its occurrence, review literature.Clinical information on all patients treated between September 2002 August 2007 was retrospectively...
Murine lymphoid cells sensitized against allografts express two types of cytotoxicity measured in vitro short-term assays 2 to 3 hr by 51Cr release. One type is specific target carrying the sensitizing alloantigens, and other nonspecific both syngeneic unrelated requires presence phytohemagglutinin (PHA) or concanavalin A (ConA). Several lines evidence are presented which demonstrate that cytotoxic systems mediated same clone alloimmune effector T lymphocytes lectin-induced not attributable...
Mitochondrial iron import is essential for iron–sulfur cluster formation and heme biosynthesis. Two nuclear-encoded vertebrate mitochondrial high-affinity importers, mitoferrin1 (Mfrn1) Mfrn2, have been identified in mammals. In mice, the gene encoding Mfrn1, solute carrier family 25 member 37 (Slc25a37), highly expressed sites of erythropoiesis, whole-body Slc25a37 deletion leads to lethality. Here, we report that mice with a Slc25a28 (encoding Mfrn2) are born at expected Mendelian ratios,...
Abstract Mating induces extensive physiological, biochemical and behavioural changes in female animals of many taxa. In contrast, the overall phenotypic transcriptomic consequences mating for males, hence how they might differ from those females, are poorly described. Post responses each sex rapidly initiated, predicting existence regulatory mechanisms addition to transcriptional involving de novo gene expression. That post appear different also predicts that genome-wide signatures should...
High-grade serous ovarian carcinoma (HGSOC) is characterised by poor outcome and extreme chromosome instability (CIN). Therapies targeting centrosome amplification (CA), a key mediator of missegregation, may have significant clinical utility in HGSOC. However, the prevalence CA HGSOC, its relationship to genomic biomarkers CIN potential impact on therapeutic response not been defined. Using high-throughput multi-regional microscopy 287 HGSOC tissues 73 cell lines models, here we show that...
Cancer patients have an increased incidence of venous thromboembolism (VTE). Inferior vena cava (IVC) filters are used extensively in the US, and more than 40 000 inserted annually. The impact on survival cancer receiving IVC has not been studied.A retrospective study examined 206 consecutive with VTE to compare effects filter placement anticoagulation (AC) therapy overall (OS), as measured from time VTE. Patients were classified into 3 treatment groups: AC (n = 62), (77), or combination +...
Abstract Low-coverage or shallow whole genome sequencing (sWGS) approaches can efficiently detect somatic copy number aberrations (SCNAs) at low cost. This is clinically important for many cancers, in particular cancers with severe chromosomal instability (CIN) that frequently lack actionable point mutations and are characterised by poor disease outcome. Absolute (ACN), measured DNA copies per cancer cell, required meaningful comparisons between states, but challenging to estimate practice...
Educators have been challenged to identify threshold concepts and develop transformed students. This stands in stark contrast many curriculum design delivery models that currently view students as repositories of knowledge. In this article, we argue educators can reach both goals, stumbling blocks transforming students, through purposeful insightful blending a using conception-focused (CFC) courses built on the integration viewing them lens discipline. process takes advantage student’s...
The presence of villous adenoma in the urinary tract is an exceedingly rare finding. On a histological and cytological level, this tissue essentially identical to that typically found colon. These lesions do have malignancy potential and, when present with coexistent adenocarcinoma, risk recurrence metastasis even after surgical resection. Although adenomas been almost exclusively treated intervention literature, we case underlying adenocarcinoma prostatic urethra was successfully combined...
ABSTRACT Objectives Over half of new cancer diagnoses occur in patients aged 65 or older, with up to 40% experiencing anxiety. The American Society Clinical Oncology recommends using the Generalized Anxiety Disorder Scale (GAD‐7) for anxiety screening, but GAD‐7 psychometric properties this population are unknown. This study examined GAD‐7's reliability, validity, and item parameters, comparing its utility GAD‐2 older adults cancer. Methods cross‐sectional secondary analysis a nationwide...
Abstract Objective One primary source of psychological distress in patients with cancer and their caregivers is uncertainty. However, the uncertainty trajectory its relationship between older adults advanced have rarely been examined. This study describes patient‐caregiver dyads, explores effect geriatric assessment (GA) intervention on trajectory, examines interdependent Methods secondary analysis used longitudinal data from a national cluster‐randomized controlled trial examining GA...