A5079264831- Glaucoma and retinal disorders
- Neurological Disorders and Treatments
- Retinal Development and Disorders
- Nitric Oxide and Endothelin Effects
- Vanadium and Halogenation Chemistry
- Biomedical Research and Pathophysiology
- Advanced Glycation End Products research
- Cerebral Venous Sinus Thrombosis
- Aldose Reductase and Taurine
Universiti Teknologi MARA
2016-2020
Hospital Sungai Buloh
2016
Endothelin-1 (ET-1), a potent vasoconstrictor, is involved in retinal vascular dysregulation and oxidative stress glaucomatous eyes. Taurine (TAU), naturally occurring free amino acid, known for its neuroprotective antioxidant properties. Hence, we evaluated properties against ET-1 induced optic nerve damage. was administered intravitreally to Sprague-Dawley rats TAU injected as pre-, co- or post-treatment. Animals were euthanized seven days post injection. Retinae examined morphology, also...
Purpose: Retinal ganglion cell apoptosis in glaucoma is associated with elevated levels of endothelin-1 (ET1), a potent vasoconstrictor. ET1-induced retinal ischemia leads to altered expression nitric oxide synthase (NOS) isoforms leading increased formation (NO) and nitrosative stress. Since magnesium (Mg) known improve endothelial functions reduce oxidative stress taurine (TAU) possesses antioxidant properties, we investigated the protective effects acetyltaurate (MgAT) against damage...