A5092035080- Malaria Research and Control
- Pregnancy and preeclampsia studies
- Complement system in diseases
- Birth, Development, and Health
- HIV Research and Treatment
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- Hemoglobinopathies and Related Disorders
- Child Nutrition and Water Access
- Immune Cell Function and Interaction
Infectious Diseases Research Collaboration
2024-2025
Makerere University
2023
Fetal growth restriction (FGR) is associated with perinatal death and adverse birth outcomes, as well long-term complications, including increased childhood morbidity, abnormal neurodevelopment, cardio-metabolic diseases in adulthood. Placental epigenetic reprogramming FGR may mediate these outcomes. malaria (PM), characterized by sequestration of Plasmodium falciparum-infected erythrocytes placental intervillous space, the leading global cause FGR, but its impact on epigenetics unknown. We...
Background We conducted a double-blinded, randomized, controlled trial of 2757 pregnant women in Uganda, where resistance malaria parasites to sulfadoxine-pyrimethamine is widespread. Women were randomly assigned (1:1:1) monthly IPTp with sulfadoxine-pyrimethamine, dihydroartemisinin-piperaquine, or dihydroartemisinin-piperaquine plus sulfadoxine-pyrimethamine. The primary outcome was the risk composite adverse birth defined as any following: spontaneous abortion, stillbirth, low birthweight...
Fetal growth restriction (FGR) is associated with perinatal death and adverse birth outcomes, as well long-term complications, including increased childhood morbidity, abnormal neurodevelopment, cardio-metabolic diseases in adulthood. Placental epigenetic reprogramming FGR may mediate these outcomes. malaria (PM), characterized by sequestration of Plasmodium falciparum-infected erythrocytes placental intervillous space, the leading global cause FGR, but its impact on epigenetics unknown. We...
Co‐administration of dihydroartemisinin–piperaquine (DP) and sulfadoxine‐pyrimethamine (SP) for intermittent preventive treatment malaria in pregnancy (IPTp) may be superior preventing adverse birth outcomes compared with either therapy alone, but potential drug–drug interactions require investigation. We conducted intensive sparse pharmacokinetic (PK) studies a subset Ugandan women participating randomized controlled trial monthly IPTp SP vs. DP + SP. Intensive PK sampling was performed...
Background: Malaria in pregnancy causes higher morbidity primigravid women compared to multigravid; however, the correlates and mechanisms underlying this gravidity-dependent protection against remain incompletely understood.Methods: We characterized cellular immune response during second trimester of pregnant (n=203) living eastern Uganda, a highly malaria-endemic region, combining RNA sequencing, multiparameter flow cytometry, functional assays. responses between multigravid assessed...