A5041202529- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Glioma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Intracranial Aneurysms: Treatment and Complications
- Anatomy and Medical Technology
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Facial Nerve Paralysis Treatment and Research
- Surgical Simulation and Training
- Adrenal and Paraganglionic Tumors
- Neurosurgical Procedures and Complications
- Spinal Fractures and Fixation Techniques
- Trigeminal Neuralgia and Treatments
- Fetal and Pediatric Neurological Disorders
- Testicular diseases and treatments
- Ear and Head Tumors
- Cerebral Venous Sinus Thrombosis
- History of Medical Practice
- Ophthalmology and Eye Disorders
- Sarcoma Diagnosis and Treatment
- Craniofacial Disorders and Treatments
- Pelvic and Acetabular Injuries
Mayo Clinic
2015-2024
Sheba Medical Center
2021-2024
WinnMed
2015-2023
University of Central Florida
2023
Florida College
2023
Mayo Clinic in Florida
2015-2022
Tel Aviv University
2022
National Institutes of Health
2021
North American Skull Base Society
2021
National Institute of General Medical Sciences
2021
<h3>BACKGROUND AND PURPOSE:</h3> Normal pressure hydrocephalus is a reversible neurologic disorder characterized by triad of cognitive impairment, gait abnormality, and urinary incontinence that commonly treated with ventriculoperitoneal shunt placement. However, multiple overlapping symptoms often make it difficult to differentiate normal from other types dementia, improved diagnostic techniques would help patient management. MR elastography novel tool could potentially identify patients...
The purpose of this study was to investigate age-corrected brain MR elastography (MRE) findings in four dementia cohorts (Alzheimer disease, with Lewy bodies, frontotemporal dementia, and normal pressure hydrocephalus) determine the potential use as a differentiating biomarker subtypes.Institutional review board approval written informed consent were obtained perform MRE on 84 subjects: 20 patients hydrocephalus, eight Alzheimer five 46 cognitively control subjects. Shear waves 60-Hz...
The complex and dynamic system of fluid flow through the perivascular interstitial spaces CNS has new-found implications for neurological diseases. CSF movement throughout parenchyma is more than could be explained via passive diffusion mechanisms alone. Indeed, a semistructured glial-lymphatic (glymphatic) astrocyte-supported extracellular channels serves to directionally channel fluid, clearing metabolites peptides optimize function. Clinical studies glymphatic network have date proven...
Synonymous variations, which are defined as codon substitutions that do not change the encoded amino acid, were previously thought to have no effect on properties of synthesized protein(s). However, mounting evidence shows these "silent" variations can a significant impact protein expression and function should longer be considered "silent". Here, effects six synonymous non-synonymous found in gene ADAMTS13, von Willebrand Factor (VWF) cleaving hemostatic protease, been investigated using...
OBJECTIVE Type II odontoid fracture is a common injury among elderly patients, particularly given their predisposition toward low-energy falls. Previous studies have demonstrated survival advantage following early surgery patients older than 65 years, yet octogenarians represent medically distinct and rapidly growing population. The authors compared operative nonoperative management in 79 years. METHODS A single-center prospectively maintained trauma database was reviewed using ICD-9 codes...
Stereotactic radiosurgery (SRS) is a safe and effective treatment for acromegaly.
Syndromic diarrhoea/tricho-hepato-enteric syndrome (SD/THE) is a rare congenital syndrome. The main features are intractable diarrhoea of infancy, hair abnormalities, facial dysmorphism, intrauterine growth restriction and immune system abnormalities. It has been linked to abnormalities in two components the putative human ski complex: SKIV2L TTC37. long-term outcome this still unknown. We aim describe outcome, French cohort patients born since 1992.Review clinical biological 15 with SD/THE,...
Idiopathic normal pressure hydrocephalus (iNPH) is a ventriculomegaly syndrome characterized by dementia, urinary incontinence, and gait disturbance, which potentially reversible after ventriculoperitoneal shunting (VPS). Magnetic resonance elastography (MRE) an evolving imaging technology that noninvasively measures tissue viscoelasticity. We studied iNPH patients using MRE prior to shunting, compared them with controls, analyzed associations between findings clinical features, as pilot...
Objective This study was aimed to provide a key update the seminal works of Prof. Albert L. Rhoton Jr., MD, with particular attention previously unpublished insights from oral tradition his fellows, recent technological advances including endoscopy, and high-dynamic range (HDR) photodocumentation, and, local improvements in technique, we have developed optimize efficient neuroanatomic study. Methods Two formaldehyde-fixed cadaveric heads were injected colored latex demonstrate step-by-step...
Sphenoorbital meningioma (SOM) is a unique skull base tumor, characterized by infiltrative involvement and hyperostosis primarily of the lesser wing sphenoid bone, with frequent orbital compartment. SOM often manifests proptosis visual impairment. Surgical technique outcome are highly variable among studies reported in literature. The authors present single-surgeon experience SOM.
Central nervous system (CNS) germ cell tumors (GCTs) are rare malignant neoplasms that arise predominantly in adolescents and young adults. CNS GCTs demonstrate characteristic trends national associations, with implications for both tumor incidence genetics. Although the of is markedly higher East Asia than Western countries, direct comparative analyses between these GCT populations limited.
The central nervous system germ cell tumor (CNS GCT) is a rare and incompletely understood disease. A major outstanding question in the 2015 consensus document for CNS GCT management was utility interpretation of markers human chorionic gonadotropin (HCG) alpha fetoprotein (AFP) diagnosis malignant non-germinomatous GCTs (hereafter NGGCTs) prior to treatment. In current study, we assembled two geographically ethnically different clinical cohorts from Mayo Clinic (1988-2017) intracranial...
<h3>BACKGROUND AND PURPOSE:</h3> Normal pressure hydrocephalus is a treatable cause of dementia associated with distinct mechanical property signatures in the brain as measured by MR elastography. In this study, we tested hypothesis that specific anatomic features normal are unique alterations. Then, summary measures these can be used to predict clinical outcomes. <h3>MATERIALS METHODS:</h3> elastography and structural imaging were performed 128 patients suspected 44 control participants....
OBJECTIVE—Congenital hyperinsulinism, usually associated with severe neonatal hypoglycemia, may progress to diabetes, typically during the 4th decade of life in nonpancreatectomized patients. We aimed genotype ATP-sensitive K+ channel a 10.5-year-old girl presenting overt diabetes following hyperinsulinism infancy. RESEARCH DESIGN AND METHODS—A female aged 10.5 years presented new-onset, antibody-negative (A1C 10.6%). She was born large for gestational age (5 kg) nondiabetic mother and...
Tumor-associated macrophages (TAMs) have been implicated as pathologic actors in phenotypically aggressive vestibular schwannoma (VS), potentially mediated via programmed death-ligand 1 (PD-L1). The authors hypothesized that PD-L1 is a key regulator of the VS immune microenvironment.
Intracranial germ cell tumors (iGCTs) often arise at the neurohypophysis, their second most common origination, following pineal region. Neurohypophyseal iGCTs present with stereotypical symptoms, including pituitary dysfunction and visual field deficit, due to suprasellar location. The goal of this study was a large, longitudinal single-institution experience neurohypophyseal better understand natural history identify opportunities for further improvement in treatment outcomes.