A5083869237- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Renal and related cancers
- RNA modifications and cancer
- Molecular Communication and Nanonetworks
- Protein Tyrosine Phosphatases
- CAR-T cell therapy research
- 3D Printing in Biomedical Research
- Cancer Research and Treatments
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Microfluidic and Bio-sensing Technologies
- Cancer Genomics and Diagnostics
- Ovarian cancer diagnosis and treatment
Saarland University
2018-2023
Autoimmune diseases (AID) such as systemic lupus erythematosus (SLE), primary Sjögren's syndrome (pSS) and rheumatoid arthritis (RA) are chronic inflammatory in which abnormalities of B cell function play a central role. Although it is widely accepted that autoimmune cells hyperactive vivo, full understanding their functional status AID has not been delineated. Here, we present detailed analysis the capabilities dissect mechanisms underlying altered function. Upon BCR activation, decreased...
Abstract In the development of orally inhaled drug products preclinical animal models regularly fail to predict pharmacological as well toxicological responses in humans. Models based on human cells and tissues are potential alternatives experimentation allowing for isolation essential processes biology making them accessible vitro. Here, generation a novel monoclonal cell line “Arlo,” derived from polyclonal alveolar epithelium lentivirus immortalized hAELVi via single‐cell printing, its...
Astrocytes from the cerebral cortex (CTX) and cerebellum (CB) share basic molecular programs, but also form distinct spatial functional subtypes. The regulatory epigenetic layers controlling such regional diversity have not been comprehensively investigated so far. Here, we present an integrated epigenome analysis of methylomes, open chromatin, transcriptomes astroglia populations isolated or young adult mice. Besides a overall similarity in their epigenomic cortical astrocytes cerebellar...
Abstract Background High-grade serous ovarian cancer (HGSOC) is a major unmet need in oncology. The remaining uncertainty on its originating tissue has hampered the discovery of molecular oncogenic pathways and development effective therapies. Methods We used an approach based retention tumors DNA methylation trace (OriPrint) that distinguishes two putative tissues origin HGSOC, fimbrial (FI) surface epithelia (OSE), to stratify HGSOC by several clustering methods, both linear non-linear....
The functions of bone marrow plasma cells (BMPC) beyond antibody production are not fully elucidated and distinct subsets BMPC suggest potential different functions. Phenotypic differences were identified for human depending on CD19 expression. Since is a co-stimulatory molecule the B-cell-receptor (BCR), IgA+ IgM+ express BCR their surface, we here studied whether expression affects cellular responses, such as signaling checkpoint molecules. We analyzed 132 BM samples from individuals...
Abstract High grade serous ovarian cancer (HGSOC) is a major unmet need in oncology. The persistent uncertainty on its originating tissue has contributed to hamper the discovery of oncogenic pathways and effective therapies. Here we define DNA methylation print that distinguishes human fimbrial (FI) surface epithelia (OSE) develop robust epigenetic cell-of-origin tracer stratifies HGSOC FI-and OSE-originated tumors across all available cohorts. We translate this origin-based stratification...
e17063 Background: The still persistent uncertainty in the identification of cell origin high grade serous ovarian cancer (HGSOC), with two candidate originating tissues identified distal tract fallopian tube (FI) and surface epithelium ovary (OSE), has hampered clinically relevant molecular features for this disease to be targeted therapy. This resulted only a negligible improvement patient’s care since introduction carboplatin-based treatments. Methods: To solve issue, here we show an...