A5103155613- Lipid metabolism and biosynthesis
- Pancreatic function and diabetes
- Protein Structure and Dynamics
- Cellular transport and secretion
- Microbial Metabolic Engineering and Bioproduction
- Endoplasmic Reticulum Stress and Disease
Genotype (Germany)
2021
Article14 September 2021Open Access Source DataTransparent process Shortening of membrane lipid acyl chains compensates for phosphatidylcholine deficiency in choline-auxotroph yeast Xue Bao orcid.org/0000-0002-5129-0728 Membrane Biochemistry & Biophysics, Bijvoet Center Biomolecular Research and Institute Biomembranes, Utrecht University, Utrecht, The Netherlands Search more papers by this author Martijn C Koorengevel Marian J A Groot Koerkamp orcid.org/0000-0002-0867-0821 Princess Máxima...
ABSTRACT Phosphatidylcholine (PC) is an abundant membrane lipid component in most eukaryotes including yeast. PC has been assigned a multitude of functions addition to that building block the bilayer. Here we show evolvable essential yeast by isolating suppressor mutants devoid exhibit robust growth. The requirement for suppressed monosomy chromosome XV, or point mutation ACC1 gene encoding acetyl-CoA carboxylase. Although these two genetic adaptations rewire biosynthesis differently, both...