A5031064774- Force Microscopy Techniques and Applications
- Mechanical and Optical Resonators
- Lipid Membrane Structure and Behavior
- Corrosion Behavior and Inhibition
- Cellular Mechanics and Interactions
- Polydiacetylene-based materials and applications
- Thermal and Kinetic Analysis
California Institute of Technology
2019-2022
Pasadena City College
2020
The development of force-responsive molecules called mechanophores is a central component the field polymer mechanochemistry. Mechanophores enable design and fabrication polymers for variety applications ranging from sensing to molecular release self-healing materials. Nevertheless, an insufficient understanding structure-activity relationships limits experimental development, thus computation necessary guide structural mechanophores. constrained geometries simulate external force (CoGEF)...
Stimuli-responsive polymers that release small molecules under mechanical stress are appealing targets for applications ranging from drug delivery to sensing. Here, we describe a modular mechanophore design platform molecular via mechanically triggered cascade reaction. Mechanochemical activation of furan–maleimide Diels–Alder adduct reveals latent furfuryl carbonate subsequently decomposes mild conditions covalently bound cargo molecule. The computationally guided reactive secondary enables...
Structure–activity relationships for strategic substitution of the naphthopyran mechanophore scaffold enable polymeric materials with tunable mechanochromic behavior.
Polymers that release functional small molecules in response to mechanical force are appealing targets for drug delivery, sensing, catalysis, and many other applications. Mechanically sensitive called mechanophores uniquely suited enable molecular with excellent selectivity control, but mechanophore designs capable of releasing cargo diverse chemical functionality limited. Here, we describe a general highly modular platform based on masked 2-furylcarbinol derivatives spontaneously decompose...