A5101808919- Pneumonia and Respiratory Infections
- Microbial infections and disease research
- Acute Lymphoblastic Leukemia research
- Streptococcal Infections and Treatments
- Respiratory and Cough-Related Research
- Cancer-related Molecular Pathways
- Pneumocystis jirovecii pneumonia detection and treatment
- Hematological disorders and diagnostics
- Thyroid Cancer Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Asthma and respiratory diseases
- Acute Myeloid Leukemia Research
- Autoimmune Neurological Disorders and Treatments
- IL-33, ST2, and ILC Pathways
- Inhalation and Respiratory Drug Delivery
- interferon and immune responses
- MicroRNA in disease regulation
- Respiratory viral infections research
- Chronic Myeloid Leukemia Treatments
Tianjin Children's Hospital
2020-2023
Objective To assess the efficacy and safety of omalizumab in children with moderate-to-severe asthma.Data sources We systematically searched MEDLINE, EMBASE, Cochrane for randomized controlled trials (RCTs ) (inception to January 2020).Study selections All RCTs which were conducted childhood adolescence asthma compared or adopted.Results Three studies four publications including 1380 pediatric patients met our criteria. For asthma, decreased exacerbations rate (OR 0.51, 95% CI: 0.44–0.58, p...
The dedifferentiation of differentiated thyroid cancer (DTC) is a challenging problem for radioactive iodine ( 131 I) treatment, also known as radioiodine refractory (RAIR-DTC). purpose this study was to further explore the mechanism redifferentiation dedifferentiated cancer. Ineffective and effective groups I therapy were analyzed compared in both our clinical TCGA samples. Whole-exome sequencing, mutation analysis, transcriptome vitro functional experiments conducted. FLG , FRG1 MUC6 MUC20...
Abstract Background : Analyze the clinical characteristics of Mycoplasma pneumoniae pneumonia with hypoxia in children, and identify related factors MPP. Methods A retrospective case-control study was performed on 345 children (MPP) hospitalized our hospital from January 2017 to June 2019. The features, laboratory data radiological findings were compared between MPP hypoxia, refractory (RMPP) general (GMPP) groups. Results patients (n=69) had a higher incidence extra-pulmonary complications...
Objective: Polo-like kinase 1 (PLK1) modulates leukemia cell apoptosis, proliferation, and cycle arrest in the progression of acute lymphoblastic (ALL). This study intended to investigate dysregulation PLK1 its association with induction therapy response prognosis pediatric ALL patients. Materials Methods: Bone marrow mononuclear samples were collected from 90 patients at baseline on 15th day (D15), as well 20 controls after enrollment, for detection by reverse transcription-quantitative...
Background: MicroRNA (miR)-185-5p participates in the pathology of asthma by regulating immune imbalance, inflammation, periostin synthesis, and smooth muscle contraction. This study intended to explore dysregulation miR-185p its correlation with T-helper (Th)1, Th2 cells, inflammatory cytokines childhood asthma. Methods: In 150 patients 30 healthy controls (HCs), miR-185-5p from peripheral blood mononuclear cells was detected using reverse transcription-quantitative polymerase chain...
Abstract BACKGROUND : Analyze the clinical characteristics of Fulminant Mycoplasma pneumoniae pneumonia (FMPP), and identify related factors predicting FMPP. METHODS A retrospective case-control study was performed on 345 children with (MPP) hospitalized in our hospital from January 2017 to June 2019. The features, laboratory data radiological findings were compared between FMPP group, refractory (RMPP)group general (GMPP) group. RESULTS patients (n=69) had a higher incidence extra-pulmonary...
Abstract BACKGROUND: Analyze the clinical characteristics of Fulminant Mycoplasma pneumoniae pneumonia (FMPP), and explore related factors predicting FMPP. METHODS: A retrospective case-control study was performed on 345 children with (MPP) hospitalized in our Hospital from January 2017 to June 2019. The features, laboratory data radiological findings were compared between FMPP group, refractory (RMPP)group general (GMPP) group. RESULTS: patients (n=69) had more severe presentations, higher...
Abstract Objective: To explore the immune characteristics and short-term prognosis of children with autoimmune encephalitis (AE), then to analyse relationship between them. Methods: A total 78 AE were identified through clinic database inpatient consults in Tianjin Children’s Hospital (238 Long-Yan Road, Bei-Chen District, Tianjin, China) from January 2018 2021. Based on recent follow-up (one-year follow-up) modified Rankin Scale (mRS) score, they divided into a good group (59 cases, mRS...