A5068337152- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- COVID-19 and healthcare impacts
- Diabetes Treatment and Management
- Cardiovascular Disease and Adiposity
- Health Systems, Economic Evaluations, Quality of Life
- Palliative Care and End-of-Life Issues
- Frailty in Older Adults
- Nutrition and Health in Aging
- Cardiac, Anesthesia and Surgical Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Chronic Disease Management Strategies
- Healthcare cost, quality, practices
- COVID-19 Clinical Research Studies
- Lipid metabolism and disorders
- Global Public Health Policies and Epidemiology
- Innovations in Medical Education
- Cardiac Arrhythmias and Treatments
- Adipose Tissue and Metabolism
- Potassium and Related Disorders
- Aortic Disease and Treatment Approaches
- Cardiovascular Health and Risk Factors
- Diet and metabolism studies
- Cardiac electrophysiology and arrhythmias
University of Leeds
2014-2025
Leeds Teaching Hospitals NHS Trust
2021-2024
Society of Interventional Radiology
2019
St James's University Hospital
2017
Universität Ulm
1990
OBJECTIVE Obesity and diabetes frequently coexist, yet their individual contributions to cardiovascular risk remain debated. We explored disease biomarkers, events, mortality in the UK Biobank stratified by BMI diabetes. RESEARCH DESIGN AND METHODS A total of 451,355 participants were ethnicity-specific categories (normal, overweight, obese) status. examined biomarkers including carotid intima-media thickness (CIMT), arterial stiffness, left ventricular ejection fraction (LVEF), cardiac...
Objective To characterise the association between socioeconomic deprivation and adverse outcomes in patients with chronic heart failure (CHF). Methods We prospectively observed 1802 CHF left ventricular ejection fraction (LVEF) ≤45%, recruited four UK hospitals 2006 2014. assessed defined by Index of Multiple Deprivation (IMD) and: mode-specific mortality (mean follow-up 4 years); hospitalisation; cumulative duration hospitalisation (after 1 year). Results A 45-point difference mean IMD...
Background Noncardiovascular death is increasingly common in people with chronic heart failure ( CHF ), yet its causes remain poorly characterized. We aimed to define the prevalence of sepsis and ascertain risk marker profile. Methods Results conducted a prospective cohort study 1802 patients left ventricular ejection fraction ≤45% attending clinics 4 United Kingdom hospitals between 2006 2014. Mode was defined over 10.3‐year follow‐up period (mean years). Competing regression mode‐specific...
BackgroundNon-communicable diseases (NCDs) have been highlighted as important risk factors for COVID-19 mortality. However, insufficient data exist on the wider context of infectious in people with NCDs. We aimed to investigate association between NCDs and death from any infection before pandemic (up Dec 31, 2019).MethodsFor this observational study, we used UK Biobank cohort study explore associated death. excluded participants if were missing comorbidities, body-mass index, smoking status,...
Background: Hospitalization is a common adverse event in people with heart failure and reduced ejection fraction, yet often not primarily due to decompensated (HF). We investigated the long-term prognosis following infection-related hospitalization. Methods: conducted prospective observational cohort study of 711 fraction recruited from 4 specialist HF clinics United Kingdom. All hospitalization episodes (n=1568) were recorded categorized as HF, other cardiovascular disease,...
Estimating survival can aid care planning, but the use of absolute projections be challenging for patients and clinicians to contextualise. We aimed define how heart failure its major comorbidities contribute loss actuarially predicted life expectancy.We conducted an observational cohort study 1794 adults with stable chronic reduced left ventricular ejection fraction, recruited from cardiology outpatient departments four UK hospitals. Data 11-year maximum (5-year median) follow-up period...
The effect of sarcopenia based on the total psoas muscle area (TPMA) CT is inconclusive in patients undergoing abdominal aortic aneurysm (AAA) intervention. aim this prospective cohort study was to evaluate morphometric as a method risk stratification elective AAA intervention.TPMA measured preintervention images endovascular repair (EVAR) or open repair. Mortality assessed relation TPMA using Cox regression analysis, with calculation hazard ratios at 30 days, 1 year and 4 years....
<h3>ABSTRACT</h3> The SARS-CoV-2 pandemic is accompanied by an ever-rising death toll attributed to coronavirus disease 2019 (COVID-19), but questions have persisted regarding deaths formally COVID-19. We aimed provide independent review of clinical features patients who died during hospitalisation with a positive PCR test for and relate these the reported cause death. Between 23 March 28 April 2020, total 162 in our NHS trust. COVID-19 infection was documented as direct 150 (93%). Review...
Abstract During recent decades, changes in lifestyle have led to widespread nutritional obesity and its related complications. Remodelling adipose tissue as a therapeutic goal for complications has attracted much attention continues be actively explored. The endothelium lines all blood vessels is close cells, including adipocytes. been suggested act paracrine organ. We explore the role of endothelial insulin-like growth factor-1 receptor (IGF-1R), modulator white phenotype. show that...
Abstract Aims Progressive deposition of cholesterol in the arterial wall characterizes atherosclerosis, which underpins most cases myocardial infarction and stroke. Insulin-like growth factor-1 (IGF-1) is a hormone that regulates systemic metabolism possesses anti-atherosclerotic properties. We asked whether endothelial-restricted augmentation IGF-1 signaling sufficient to suppress atherogenesis. Methods Results generated mice with over-expression human wildtype IGF-1R (hIGFREO/ApoE-/-) or...
OBJECTIVE Diabetes increases mortality in patients with chronic heart failure (CHF) and reduced left ventricular ejection fraction. Studies have questioned the safety of β-adrenoceptor blockers (β-blockers) some diabetes We examined whether β-blockers ACE inhibitors (ACEIs) are associated differential effects on CHF without diabetes. RESEARCH DESIGN AND METHODS conducted a prospective cohort study 1,797 recruited between 2006 2014, mean follow-up 4 years. β-Blocker dose was expressed as...
Low 25-hydroxyvitamin D (25[OH]D) concentrations have been associated with adverse outcomes in selected populations established chronic heart failure (CHF). However, it remains unclear whether 25[OH]D deficiency is mortality and hospitalisation unselected patients receiving contemporary medical device therapy for CHF. We prospectively examined the prevalence correlates of 1802 ambulatory CHF due to left ventricular systolic dysfunction (left ejection fraction ≤ 45%) attending clinics north...
Observational studies investigating risk factors in coronavirus disease 2019 (COVID-19) have not considered the confounding effects of advanced care planning, such that a valid picture for elderly, frail and multi-morbid patients is unknown. We aimed to report ceiling cardiopulmonary resuscitation (CPR) decisions their association with demographic clinical characteristics as well outcomes during COVID-19 pandemic.Retrospective, observational study conducted between 5th March 7th May 2020 all...
Optimal management of heart failure with reduced ejection fraction (HFrEF) includes titration guideline-directed medical therapy (GDMT) to the highest tolerated dose within licensed range. During hospitalization, GDMT doses are often significantly altered, although it is unknown whether cause hospitalization influences this.
Abstract Aims Current guidelines recommend that disease-modifying pharmacological therapies may be considered for patients who have heart failure with mildly reduced ejection fraction (HFmrEF). We aimed to describe the characteristics, outcomes, provision of and dose-related associations mortality risk in HFmrEF. Methods results explored data from two prospective observational studies, which permitted examination effects across a broad spectrum left ventricular (LVEF). The combined dataset...
This study sought to examine whether the heart rate (HR) at which force-frequency relationship (FFR) slope peaks (critical HR) could be used tailor HR response in chronic failure (CHF) patients with cardiac pacemakers and this favorably influences exercise capacity.CHF secondary left ventricular (LV) systolic dysfunction is characterized by blunting of positive between LV contractility known as FFR.This observational was carried out CHF healthy subjects pacemaker devices. The assessed 3...
Diabetes mellitus (DM) increases heart failure incidence and worsens prognosis, but its molecular basis is poorly defined in humans. We aimed to define the diabetic myocardial transcriptome validate hits their circulating protein form disease mechanisms biomarkers.
We investigated whether total psoas muscle area (TPMA) was representative of the volume (TPMV). Secondly, we assessed there a relationship between two commonly used single slice measurements sarcopenia, TPMA and abdominal (TAMA).Pre-operative CT imaging 110 patients undergoing elective endovascular aneurysm repair were analyzed by trained independent observers. measured at individual vertebral levels second lumbar vertebrae sacrum. TPMV also estimated TAMA third (L3). Observer differences...
Background Therapeutic advances have reduced cardiovascular death rates in people with diseases (CVD). We aimed to define the of and noncardiovascular specified CVDs or accruing multimorbidity. Methods Results studied 493 280 UK residents enrolled Biobank cohort study. The proportion deaths attributed cardiovascular, cancer, infection, other causes were calculated groups defined by 9 distinct self-reported at baseline, number these baseline. Poisson regression analyses then used adjusted...