A5049316533- Advanced Glycation End Products research
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Global Health and Surgery
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Metabolomics and Mass Spectrometry Studies
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Impact on Reproduction
- Cardiovascular Function and Risk Factors
- Neonatal Respiratory Health Research
- Nutrition and Health in Aging
- Biochemical effects in animals
- Alcohol Consumption and Health Effects
- Birth, Development, and Health
- Maternal Mental Health During Pregnancy and Postpartum
- Heart Rate Variability and Autonomic Control
- Infant Development and Preterm Care
- Colorectal Cancer Screening and Detection
- Adipokines, Inflammation, and Metabolic Diseases
- COVID-19 and healthcare impacts
- Diet and metabolism studies
- Breastfeeding Practices and Influences
Assistance Publique – Hôpitaux de Paris
2023
Université Paris-Saclay
2023
Inserm
2023
University of Coimbra
2016-2020
Microvascular dysfunction has been suggested to trigger adipose tissue in obesity. This study investigates the hypothesis that glycation impairs microvascular architecture and expandability with an impact on insulin signalling. Animal models supplemented methylglyoxal (MG), maintained a high-fat diet (HFD) or both (HFDMG) were studied for periepididymal (pEAT) hypoxia local systemic resistance. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was used quantify blood flow vivo,...
BackgroundThe benefits of facilitating breastmilk feeding and close contact between mother neonate (family-centred care; FCC) in the perinatal period are well-established. The aim this study was to determine how delivery FCC practices were impacted for neonates born mothers with SARS-CoV-2 infection during COVID-19 pandemic.MethodsNeonates confirmed pregnancy identified from 'EsPnIC Covid paEdiatric NeonaTal REgistry' (EPICENTRE) multinational cohort 10 March 2020 20 October 2021. EPICENTRE...
Background Type‐2 diabetes mellitus (T2DM) is a metabolic disorder with broad range of complications in the brain that depend on conditions precede its onset, such as obesity and syndromes. It has been suggested neurotransmitter perturbations may emerge even before early stages T2DM high‐caloric intake could adversely influence states. Notwithstanding, evidence for neurochemical structural alterations these are still sparse controversial. Purpose To evaluate high‐fat diet profile integrity...
Nonalcoholic fatty liver disease (NAFLD) is caused by excessive lipid accumulation, but insulin resistance specifically associated with impaired saturation, oxidation, and storage (esterification), besides increased de novo lipogenesis. We hypothesized that dietary glycotoxins could impair hepatic metabolism in obesity contributing to lipotoxicity-driven thus the onset of nonalcoholic steatohepatitis (NASH). In diet-induced obese rats methylglyoxal-induced glycation, magnetic resonance...
Objectives: Non-alcoholic fatty liver disease (NAFLD) is an insulin resistance- and lipotoxicity-related condition. We evaluated the role of glycation, often present without overt hyperglycaemia like in prediabetes obesity1, dysregulation hepatic lipid metabolism induction glucose dysmetabolism. Methods: An animal model high-triglyceride diet-induced obesity (HFD), methylglyoxal (MG)-induced glycation (MG) or both (HFDMG) was used to asses species vivo by 1H nuclear magnetic resonance...
Aims/hypothesis: Microvascular dysfunction has been suggested as a trigger for adipose tissue (AT) in obesity[1]. We investigated the role of glycation[2] impairing AT capillarization, blood flow and expandability. Methods: used an animal model high-fat diet supplemented with methylglyoxal (HFDMG), compared (HFD) or (MG) alone type 2 diabetic Goto-Kakizaki rats (GK). Hypoxia, angiogenic pathways, insulin resistance (through magnetic resonance imaging) were addressed. MG effects on...
Abstract Introduction Early life stress, such as prenatal exposure to exogenous glucocorticoids (GC), can have a negative impact on brain development. Dexamethasone (DEX) is synthetic GC used in preterm pregnancies promote lung maturation. However, DEX induces an anxious-like behaviour male and female offspring at adulthood. Notably, only males respond positively therapeutics with proposed anxiolytic. Objectives Since the influence of neurodevelopmental remains be elucidated could help...