A5079962327- Oral microbiology and periodontitis research
- Enzyme Production and Characterization
- Machine Learning in Bioinformatics
- Parasites and Host Interactions
- Probiotics and Fermented Foods
- Oral Health Pathology and Treatment
- Gut microbiota and health
- Child Nutrition and Water Access
- HIV/AIDS oral health manifestations
- Immune responses and vaccinations
Instituto Butantan
2025
Universidade de São Paulo
2025
Universidade Federal da Bahia
2021-2023
Instituto de Saúde
2022
Dental caries is a multifactorial chronic-infection disease, which starts with bacterial biofilm formation caused mainly by Streptococcus mutans. The use of probiotics has shown numerous health benefits, including in the fight against oral diseases. Strains Lactobacillus fermentum have already probiotic potential S. mutans, but there are still few studies. Thus, aim our study was to evaluate antimicrobial activity inoculum and metabolites produced L. TcUESC01 mutans UA159. For this, growth...
Bacillus Calmette-Guérin (BCG) is one of the most successful vaccines in world and evidence suggests it can be used as a bacterial vector to deliver heterologous antigens. We evaluated whether BCG could biotinylated carrier Schistosoma mansoni antigen tetraspanin-2 (TSP-2) fused with rhizavidin, an avidin analog. was grown biotinylated. The recombinant protein Rzv:TSP-2 produced purified from Escherichia coli. biotinylation coupling analysed by flow cytometry, enzyme-linked immunosorbent...
Dental caries is a global public health problem, being the most common non-communicable disease. Streptococcus mutans, causative agent of human cariogenic dental biofilms, produce glycosyltransferases (Gtfs) whose gene expression modulated by VicRK system, which makes them promising target for biofilm inhibitor developments. Bioinformatics have playing significant role in drug discovery programs mainly novel hit identification. In this study, potential inhibitors against S. mutans VicK...
Background: Dental caries is a global public health problem, being the most common non-communicable disease. Streptococcus mutans causative agent that develops cariogenic dental biofilms in humans due to its ability produce glycosyltransferases (Gtfs). These Gtfs act exopolysaccharides synthesis (EPS) form biofilms. The gene expression encoding modulated by VicRK system, which are promising targets for biofilm inhibitor developments. Objective: Predict druggable sites of VicK protein through...