A5045525216- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Control Systems and Identification
- Genomics and Phylogenetic Studies
- Evolution and Genetic Dynamics
- Evolutionary Game Theory and Cooperation
- Microbial Community Ecology and Physiology
- Health and Medical Studies
- Real-time simulation and control systems
- Advanced Control Systems Optimization
- Fault Detection and Control Systems
- Model-Driven Software Engineering Techniques
- Bioinformatics and Genomic Networks
- Metabolomics and Mass Spectrometry Studies
- Ecosystem dynamics and resilience
- Modeling and Simulation Systems
- Tryptophan and brain disorders
- Model Reduction and Neural Networks
- Dynamics and Control of Mechanical Systems
- Bacteriophages and microbial interactions
- Probabilistic and Robust Engineering Design
- Mental Health Research Topics
- Flexible and Reconfigurable Manufacturing Systems
- Time Series Analysis and Forecasting
- Blood donation and transfusion practices
Futures Group (United States)
2022-2025
Hebrew University of Jerusalem
2018-2023
Massachusetts Institute of Technology
2009-2017
Living Systems (United States)
2016-2017
MathWorks (United States)
2006-2013
University of Michigan
1993-2005
University of Waterloo
2005
Ford Motor Company (United States)
2000
High-throughput sequencing based techniques, such as 16S rRNA gene profiling, have the potential to elucidate complex inner workings of natural microbial communities - be they from world's oceans or human gut. A key step in exploring data is identification dependencies between members these communities, which commonly achieved by correlation analysis. However, it has been known since days Karl Pearson that analysis type generated techniques (referred compositional data) can produce...
Disturbance to human microbiota may underlie several pathologies. Yet, we lack a comprehensive understanding of how lifestyle affects the dynamics human-associated microbial communities.Here, link over 10,000 longitudinal measurements wellness and action daily gut salivary two individuals course one year. These time series show overall communities be stable for months. However, rare events in each subjects’ life rapidly broadly impacted dynamics. Travel from developed developing world...
Genetic exchange is common among bacteria, but its effect on population diversity during ecological differentiation remains controversial. A fundamental question whether advantageous mutations lead to selection of clonal genomes or, as in sexual eukaryotes, sweep through populations their own. Here, we show that two recently diverged ocean has occurred akin a mechanism: few genome regions have swept subpopulations habitat-specific manner, accompanied by gradual separation gene pools...
Mapping the ecological networks of microbial communities is a necessary step toward understanding their assembly rules and predicting temporal behavior. However, existing methods require assuming particular population dynamics model, which not known priori. Moreover, those fitting longitudinal abundance data, are often informative enough for reliable inference. To overcome these limitations, here we develop new method based on steady-state data. Our can infer network topology inter-taxa...
Enterohemorrhagic Escherichia coli (EHEC), particularly serotype O157:H7, causes hemorrhagic colitis, hemolytic uremic syndrome, and even death. In vitro studies showed that Shiga toxin 2 (Stx2), the primary virulence factor expressed by EDL933 (an O157:H7 strain), is encoded 933W prophage. And bacterial subpopulation in which prophage induced producer of Stx2. Using germ-free mouse, we show essential role induction plays infection. An derivative with a single mutation its prophage,...
According to theory, sympatric speciation in sexual eukaryotes is favored when relatively few loci the genome are sufficient for reproductive isolation and adaptation different niches. Here we show a similar result clonally reproducing bacteria, but which comes about reasons. In simulated microbial populations, there an evolutionary tradeoff between early late stages of niche adaptation, resolved required adaptation. At stages, recombination accelerates new niches (ecological speciation) by...
In order to understand the function and structure of microbial communities, one must know all pairwise interactions that occur between different species within community, as these shape community’s functioning. However, measuring can be an extremely difficult task especially when dealing with big complex communities.
Abstract Introduction Optimal use of HIV testing resources accelerates progress towards ending as a global threat. In Kenya, current practices yield 2.8% positivity rate for new diagnoses reported through the national electronic medical record (EMR) system. Increasingly, researchers have explored potential machine learning to improve identification people with undiagnosed referral testing. However, few studies used routinely collected programme data basis implementing real‐time clinical...
Most organisms devote a great deal of time and energy to locating consuming food, making efficient foraging crucial for their evolutionary success. Consequently, Optimal Foraging has been widely studied, but mainly in relatively complex animals with strong sensory cognitive abilities. However, most living organisms, from bacteria lower invertebrates, lack these abilities still must forage efficiently. Here we extend one the main theorems Foraging, Marginal Value Theorem, minimal abilities;...
Introduction Microbes typically form diverse communities of interacting species, whose activities have tremendous impact on the plants, animals, and humans they associate with 1–3 , as well biogeochemistry entire planet 4 . The ability to predict structure these complex is crucial understanding, managing, utilizing them 5 Here, we propose a simple, qualitative assembly rule that predicts community from outcomes competitions between small sets experimentally assess its predictive power using...
Abstract Interspecies interactions shape the structure and function of microbial communities. In particular, positive, growth-promoting can significantly affect diversity productivity natural engineered However, prevalence positive conditions in which they occur are not well understood. To address this knowledge gap, we used kChip, an ultra-high throughput coculture platform, to measure 180,408 among 20 soil bacteria across 40 carbon environments. We find that interactions, often described...
Automotive systems are becoming increasingly difficult and expensive to design successfully as the market demands increasing complexity. Body electronics particularly affected by this trend, a good example being power windows design. This seemingly mundane area involves meeting legislative requirements, which means creating control system that combines input from several sensors follows complex behavioral rules (Prabhu Mosterman, 2004). Traditional methodologies involve writing text...
Today, many leading automotive OEMs and Suppliers are adopting Model-Based Design for the development of embedded systems applications. In this paper, authors review challenges performing configuration management that is adequate use in a production environment models associated files central to Design.