A5074974341- Circadian rhythm and melatonin
- Bat Biology and Ecology Studies
- Neural dynamics and brain function
- Semantic Web and Ontologies
- Sleep and Wakefulness Research
- Spaceflight effects on biology
- Bioinformatics and Genomic Networks
- Research Data Management Practices
- Birth, Development, and Health
- Scientific Computing and Data Management
- Genetics, Bioinformatics, and Biomedical Research
- Artificial Intelligence in Healthcare and Education
- Molecular Biology Techniques and Applications
- Academic Publishing and Open Access
- Pneumonia and Respiratory Infections
- Artificial Intelligence in Healthcare
- Data Mining Algorithms and Applications
- Dietary Effects on Health
- Antimicrobial Resistance in Staphylococcus
- Pharmacological Effects and Assays
- Gene Regulatory Network Analysis
- Thermal Regulation in Medicine
- Gene expression and cancer classification
- Ion channel regulation and function
- Streptococcal Infections and Treatments
National Institute on Aging
2023
National Institute of Diabetes and Digestive and Kidney Diseases
2019
National Institutes of Health
2015-2019
National Heart Lung and Blood Institute
2013-2014
Center for Genomic Science
2007
Stanford University
1996-2004
University of California, Berkeley
1999-2003
Wellesley College
1998
Biomedical research has and will continue to generate large amounts of data (termed ‘big data’) in many formats at all levels. Consequently, there is an increasing need better understand mine the further knowledge foster new discovery. The National Institutes Health (NIH) initiated a Big Data Knowledge (BD2K) initiative maximize use biomedical big data. BD2K seeks define how extract value from data, both for individual investigator overall community, create analytic tools needed enhance...
Understanding the human condition is a Big Data problem. This statement nicely illustrated by articles that follow from seven of Centers for Excellence have been funded National Institutes Health (NIH) to Knowledge (BD2K) initiative. BD2K trans-NIH program, all and at NIH as well Common Fund; it overseen Office Science within Director. The beginnings described previously,1 purpose here provide an overall context, …
Exposure of experimental animals to increased angiotensin II (ANG II) induces hypertension associated with cardiac hypertrophy, inflammation, and myocardial necrosis fibrosis. Some the most effective antihypertensive treatments are those that antagonize ANG II. We investigated gene expression in response acute (24 h) chronic (14 day) infusion mice; 24-h treatment hypertension, 14-day extensive hypertrophy necrosis. For genes differentially expressed treatment, we tested for significant...
Sleep is regulated by independent yet interacting circadian and homeostatic processes. The present study used a novel approach to sleep homeostasis in the absence of influences exposing Siberian hamsters simple phase delay photocycle make them arrhythmic. Because these lacked any organization, their could be studied interactions. Control animals retained rhythmicity after shift re-entrained phase-shifted photocycle. These displayed robust daily sleep-wake rhythms with consolidated during...
Electroencephalographic slow-wave activity (SWA) in non-rapid eye movement (NREM) sleep is directly related to prior sleep/wake history, with high levels of SWA following extended periods wake. Therefore, has been thought reflect the level accumulated need. The discovery that euthermic intervals between hibernation bouts are spent primarily and this characterized by monotonically declining led speculation homeostasis may play a fundamental role regulation timing periodic arousals euthermia....
Exposure to low ambient temperatures (T a ) accelerates appearance of the winter phenotype in Siberian hamsters transferred from long short day lengths. Because melatonin transduces effects length on neuroendocrine axis, authors assessed whether T promotes transition winterlike traits by accelerating onset increased nocturnal secretion or enhancing responsiveness Male were 16L (16 h light/day) 8L (8 photoperiods and held at 5 °C 22 °C. Locomotor activity was recorded continuously, body mass,...
We sought to determine whether ambient temperature (T a ) affects gonadal function by altering the rate at which circadian rhythms entrain short day lengths. Syrian hamsters were housed in cages where they received 14 h of light per (“long days,” 14L) 22°C. Hamsters then transferred receive 10 (“short 10L) and kept 5, 22, or 28°C maintained 14L Body mass estimated testis volume as well duration nocturnal locomotor activity (α), previously established reliable indicator melatonin secretion,...
We investigated circadian and homeostatic regulation of nonrapid eye movement (NREM) sleep in golden-mantled ground squirrels during euthermic intervals between torpor bouts. Slow-wave activity (SWA; 1–4 Hz) sigma (10–15 represent the two dominant electroencephalographic (EEG) frequency components NREM sleep. EEG has a strong component addition to component, whereas SWA mainly reflects homeostasis [Dijk DJ Czeisler CA. J Neurosci 15: 3526–3538, 1995; Dijk DJ, Shanahan TL, Duffy JF, Ronda JM,...
Brain temperature (Tbr), vigilance state, and electroencephalograph slow-wave activity (EEG SWA, 1.0-4.0 Hz) were measured during hibernation spontaneous arousals to euthermia in seven golden-mantled ground squirrels (Spermophilus lateralis). Animals held at air temperatures (Ta) ranging from 6 21 degrees C. SWA was used as a measure of the intensity non-rapid eye movement (NREM) sleep. Squirrels that had hibernated high Ta lower NREM sleep hours following arousal than when they low Ta....
Siberian hamsters as young 16 and 28 d displayed torpor in response to treatment with 2,500 mg/kg 2‐deoxy‐D‐glucose reduced food availability, respectively. In addition, most food‐restricted increased locomotor activity elevated body temperatures the 3 h immediately preceding daily delivery. This anticipatory disappeared within a few days of reimposition ad lib. feeding. Torpor first appeared spontaneously at ∼13 wk age fed maintained short day lengths. The onset this “spontaneous” was...
Arousal from deep hibernation is accompanied by a transient rise of melatonin (Mel) in circulation; there are no comparable analyses Mel concentrations species that undergo much shallower, shorter duration episodes daily torpor. Serum were determined during arousal both natural torpor and induced 2‐deoxy‐D‐glucose (2‐DG) treatment (2,500 mg/kg, intraperitoneal [IP]); blood samples drawn the retro‐orbital sinus anesthetized Siberian hamsters. For animals kept darkness torpor, highest early...
Abstract As more datasets, tools, workflows, APIs, and other digital resources are produced by the research community, it is becoming increasingly difficult to harmonize organize these efforts for maximal synergistic integrated utilization. The Findable, Accessible, Interoperable, Reusable (FAIR) guiding principles have prompted many stakeholders consider strategies tackling this challenge making follow common standards best practices so that they can become organized. Faced with question of...
Tremors are common in mammals emerging from anesthesia. To determine whether appropriate thermal manipulations immediately before emergence anesthesia sufficient to eliminate these tremors, electroencephalographic (EEG) and electromyographic (EMG) activities, hypothalamic temperature (Thy), O2 consumption were monitored 12 rats recovering halothane under three regimes. EEG EMG activities recorded throughout served as feedback signals for controlling anesthetic depth. During anesthesia, Thy...
Circadian activity rhythms of most Siberian hamsters (Phodopus sungorus sungorus) fail to reentrain a 5-h phase shift the light-dark (LD) cycle. Instead, their free-run at periods close 25 h despite continued presence LD This lack behavioral reentrainment necessarily means that molecular oscillators in master circadian pacemaker, SCN, were unable as well. The authors tested hypothesis cycle rendered SCN incapable responding photic input. Animals exposed delay photocycle, and monitored until...
Abstract In Siberian hamsters, day length is encoded by the duration of nocturnal melatonin signal; short and long signals over course several weeks stimulate inhibit somatic gonadal development, respectively, in prepubertal males. We sought to determine whether juvenile male hamsters respond multiple each manner which sequence melatonin‐free interval between affects development. Twenty‐one old gestated maintained a short‐day photoperiod 10 h light/day (10 L), were transferred constant light...