A5043093148- Drug Transport and Resistance Mechanisms
- Alzheimer's disease research and treatments
- Trace Elements in Health
- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Pharmacological Effects and Toxicity Studies
- Fatty Acid Research and Health
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Birth, Development, and Health
- Health and Lifestyle Studies
- Eicosanoids and Hypertension Pharmacology
- Advanced Drug Delivery Systems
- Nuclear Receptors and Signaling
- Diagnosis and Treatment of Venous Diseases
- Cancer, Hypoxia, and Metabolism
- Family and Disability Support Research
- GDF15 and Related Biomarkers
- Diabetes, Cardiovascular Risks, and Lipoproteins
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Infant Nutrition and Health
- Lymphatic System and Diseases
- Cardiovascular Health and Risk Factors
University of Utah
2025
Oxford Instruments (United Kingdom)
2024
Oklahoma City University
2023
Dorothy Pattison Hospital
2019
National Research Council Canada
2013
Institute for Biological Sciences
2006-2010
National Academies of Sciences, Engineering, and Medicine
2008
Alzheimer's disease (AD) is characterized by accumulation and deposition of Abeta peptides in the brain. cerebrovessels occurs many AD patients results cerebral amyloid angiopathy (AD/CAA). Since can be transported across blood-brain barrier (BBB), aberrant trafficking BBB may contribute to brain CAA development. Expression analyses 273 BBB-related genes performed this study showed that drug transporter, ABCG2, was significantly upregulated brains AD/CAA compared with age-matched controls....
Dravet syndrome (DS) and Lennox-Gastaut (LGS) are rare developmental epileptic encephalopathies associated with seizure nonseizure symptoms. A comprehensive understanding of how many individuals affected globally, the diagnostic journey they face, extent mortality these conditions is lacking. Here, we summarize evaluate published data on epidemiology DS LGS in terms prevalence, incidence, diagnosis, genetic mutations, sudden unexpected death epilepsy (SUDEP) rates. The full study protocol...
Abstract Fully elucidating the burden that Lennox–Gastaut syndrome (LGS) places on individuals with disease and their caregivers is critical to improving outcomes quality of life (QoL). This systematic literature review evaluated global illness LGS, including clinical symptom burden, care requirements, QoL, comorbidities, caregiver economic treatment (PROSPERO ID: CRD42022317413). MEDLINE, Embase, Cochrane Library were searched for articles met predetermined criteria. After screening 1442...
Aβ transport (flux) across the blood-brain barrier (BBB) is thought to contribute pathogenesis of Alzheimer's disease as well elimination toxic amyloid from brain by immunotherapy. Several BBB transporters have been implicated in exchange between parenchyma and circulation, including efflux P-glycoprotein/ABCB1 BCRP/ABCG2. Here we describe an application vivo optical imaging methods study wild-type or animals deficient specific transporters. Synthetic human Aβ1-40 scrambled Aβ40-1 peptides...
The development of BPD in preterm neonates is increased by poor growth and nutritional deficits. involvement the fatty acid DHA has been a focus for over decade. However, recent clinical trials show that isolated supplementation may increase subgroups neonates. One explanation lung outcomes DHA-supplemented disruption global profiles expression dominant-negative splice variant key driver development, PPARγ. We previously developed rat model postnatal restriction (PGR) which pups...
The development of BPD in preterm neonates is increased by poor growth and nutritional deficits. involvement the fatty acid DHA has been a focus for over decade. However, recent clinical trials show that isolated supplementation may increase subgroups neonates. One explanation lung outcomes DHA-supplemented disruption global profiles expression dominant-negative splice variant key driver development, PPARγ. We previously developed rat model postnatal restriction (PGR) which pups have...
Lymphoedema is a long-term chronic condition that results from lymphatic insufficiency and may cause skin changes, which can discomfort impact patient' quality of life. The four cornerstones lymphoedema management are exercise, massage, compression care. This article critically examines self-management in focusing on Patients initially demonstrate enthusiasm to undertake the required care independently. However, psychosocial factors, such as financial burden physical restraints, affect...
Alzheimer 's disease (AD) is characterized by accumulation and deposition of Aβ peptides in brain. binds heme forming a complex with peroxidase activities that generates increased levels non-heme iron. Liable iron causes ROS activation, transcription oxidant dependent genes APP. ABCG2 membrane efflux transporter regulates cellular porphyrin levels. induced during hypoxic stress as protective mechanism to regulate toxic protect the brain from substrate accumulation. This study examines role...
Honoring the Gift of Heart Health (HGHH) is a cardiovascular health education curriculum culturally tailored for American Indians (AI). It emphasizes adoption recommendations through lifestyle changes. The NHLBI has not revised HGHH components since 2006. Effectiveness may change overtime and updates be required to influence community behaviors. Therefore, we aimed determine cultural values practices necessary inspiring heart healthy behaviors make on including these in curriculum. We used...
Aβ is a product derived from sequential proteolytic cleavage of β–amyloid precursor protein (APP) by β–and γ–secretases, while APP α–and γ–secretases does not yield Aβ. Since are located in cholesterol–rich lipid rafts cell membrane and α–secretase phospholipid–rich domains membrane, the activities these secretases processing may be subject to changes cholesterol or/and phospholipids cellular membrane. A group ATP–binding cassette (ABC) transporters known transport regulate cells, such as...
Alzheimer's disease (AD) is characterized by accumulation and deposition of Aβ peptides in the brain. Experimental studies showed that can be transported across blood-brain barrier (BBB). Aberrant transport BBB may contribute to Some suggested mis-folded transmitted via transfusion from donors recipients, which a risk factor AD pathogenesis. Several transporters/receptors are involved BBB. MDR-1 P-glycoprotein/ABCB1 (Pgp) highly expressed cerebroendothelial cells acts as major drug...
Alzheimer's disease (AD) is characterized by accumulation and deposition of Aβ peptides in the brain. Experimental studies showed that can be transported across blood-brain barrier (BBB) into or out-of ABCG2 an ATP-dependent membrane efflux transporter expressed at BBB (W. Zhang et al. FASEB J. 17:2085, 2003). We found overexpressed brain with cerebral amyloid angiopathy (D. Callaghan ICAD2008). This study examines involvement transport Aβ1–40 BBB. Cloned hABCG2 empty vector was transfected...
Neuroinflammation is an important mechanism of Alzheimer's disease (AD)–associated neurodegeneration. Accumulation and deposition Aβ around neurovasculature found in the majority AD patients. However, little known whether would result chronic vascular inflammation insufficiency, which may contribute to We showed previously that Aβ1–40 induces strong expression inflammatory genes primary cultured human brain endothelial cells (HBEC) by semi–quantitative RT–PCR analyses, including IL–1β,...
<h3>Background</h3> Despite advances in end of life and palliative care terms education awareness, inequalities still exist, including for people with learning disabilities (Care Quality Commission, 2016). As a hospice passion inclusion, we have partnered SWALLOW charity to establish programme meet this need. was established 1993 by their families develop new way meeting needs; provide an alternative day centres residential homes. We estimate approximately 160 patients family members may...