A5006818369- Nuclear Receptors and Signaling
- Circular RNAs in diseases
- Macrophage Migration Inhibitory Factor
- Acute Lymphoblastic Leukemia research
- Synthesis of Tetrazole Derivatives
- Virus-based gene therapy research
- Sarcoma Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Estrogen and related hormone effects
- Viral gastroenteritis research and epidemiology
- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders Research
- Viral Infectious Diseases and Gene Expression in Insects
- Signaling Pathways in Disease
- Retinoids in leukemia and cellular processes
- Vascular Tumors and Angiosarcomas
- Bone Tumor Diagnosis and Treatments
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Cancer Treatment and Pharmacology
- MicroRNA in disease regulation
- Pharmacogenetics and Drug Metabolism
St. Jude Children's Research Hospital
2012-2024
Vector (United States)
2024
University of Tennessee Health Science Center
2012-2016
University of Birmingham
2004
Objective. We have investigated whether there is evidence that patients with soft tissue sarcomas do better if treated in a specialist centre compared district general hospitals.Patients. All diagnosed who were residents of WMRHA between 1994 and 1996, minimum follow up 5 years, excluding head neck or retroperitoneal tumors.Methods. reviewed data from the Royal Orthopaedic Hospital Oncology Service (ROHOS) database Cancer Intelligence Unit (CIU) Database, medial record review where...
Abstract Nuclear receptor subfamily 4 group A member 2 ( NR4A2 ) is an orphan nuclear that over-expressed in cancer and promotes cell proliferation, migration, transformation chemoresistance. Increased expression function of have been attributed to various signaling pathways, but little known about microRNA (miRNA) regulation cancer. To investigate the posttranscriptional , we used a 3′ untranslated region (UTR) reporter screen identified miR-34 as putative regulator . By using computer...
The nuclear receptor Nur77 is commonly upregulated in adult cancers and has oncogenic functions. an immediate-early response gene that acts as a transcription factor to promote proliferation protect cells from apoptosis. Conversely, can translocate the mitochondria induce apoptosis upon treatment with various cytotoxic agents. Because cancer may have role progression, it of interest understand mechanism controlling its expression. MicroRNAs (miRNAs) are responsible for inhibiting translation...
Vincristine (VCR) is one of the most widely prescribed medications for treating solid tumors and acute lymphoblastic leukemia (ALL) in children adults. However, its major dose-limiting toxicity peripheral neuropathy that can disrupt curative therapy. Peripheral also persist into adulthood, compromising quality life childhood cancer survivors. Reducing VCR-induced neurotoxicity without anticancer effects would be ideal. Here, we show low expression NHP2L1 associated with increased sensitivity...
Successful cell and gene therapy clinical trials have resulted in the US Food Drug Administration European Medicines Agency approving their use for treatment of patients with certain types cancers monogenetic diseases. These novel therapies, which rely heavily on lentiviral vectors to deliver therapeutic transgenes patient cells, driven additional investigations, increasing demand both pre-clinical current Good Manufacturing Practices-grade viral vectors. To better support studies by...
Abstract Nuclear receptor (NR) subfamily 4 member 2 (NR4A2), also known as Nurr1, has been shown to have oncogenic properties, in which it can mediate cell transformation, migration and drug resistance. However, the manner Nurr1 mediates these cancer-promoting features is not completely understood, but research implicates p53 a potential intermediary. In this study, we show that enhances proliferative rate of colorectal cancer cells. This increase growth accompanied by an upregulation cyclin...
The nuclear receptor Nur77 is commonly upregulated in adult cancers and has oncogenic functions. an immediate‐early response gene that acts as a transcription factor to promote proliferation protect the cell from apoptosis. Conversely, can translocate mitochondria induce apoptosis upon treatment with various cytotoxic agents. Because cancer may have role progression, it of interest understand mechanism controlling its expression. MicroRNAs (miRNAs) are responsible for inhibiting translation...
Nur77, an orphan nuclear receptor, has been shown to be overexpressed in adult cancers when compared normal cells, indicating a role proliferation. Nur77 is also implicated apoptosis. Nuclear‐accumulated promotes cell survival, whereas cytoplasmic accumulation death. We have found that gene and protein are expressed at high levels pediatric rhabdomyosarcoma cells human myoblasts, the malignant phenotype of these cells. Pediatric tumor models with higher expression were more susceptible death...
Background: Following our 2015 elucidation of the CASP1/NALP3 inflammasome mechanism glucocorticoid (GC)-resistance in pediatric acute lymphoblastic leukemia (ALL) patients, we engineered a cell-based reporter system suitable for high-throughput screening (HTS) small molecule libraries, with purpose identifying compounds capable inhibiting and synergizing GC drugs treatment GC-resistant ALL patients various autoinflammatory diseases. Methods: A Dox-controlled was utilized to induce...