A5023509015- Neuroscience of respiration and sleep
- Thermal Regulation in Medicine
- High Altitude and Hypoxia
- Heart Rate Variability and Autonomic Control
- Neuroendocrine regulation and behavior
- Heme Oxygenase-1 and Carbon Monoxide
- Physiological and biochemical adaptations
- Sleep and Wakefulness Research
- Adipose Tissue and Metabolism
- Sulfur Compounds in Biology
- Obstructive Sleep Apnea Research
- Stress Responses and Cortisol
- Regulation of Appetite and Obesity
- Vagus Nerve Stimulation Research
- Respiratory Support and Mechanisms
- Bat Biology and Ecology Studies
- Immune Response and Inflammation
- Biochemical effects in animals
- Nitric Oxide and Endothelin Effects
- Cannabis and Cannabinoid Research
- Circadian rhythm and melatonin
- Hydrogen's biological and therapeutic effects
- Pain Mechanisms and Treatments
- Neonatal Respiratory Health Research
- Eicosanoids and Hypertension Pharmacology
Universidade de São Paulo
2016-2025
Universidade de Ribeirão Preto
2008-2023
Hospital Universitário da Universidade de São Paulo
2023
Universidade Brasil
1999-2014
Fundação Oswaldo Cruz
2014
Fundação Faculdade de Odontologia
1998-2011
SUPERA Park of Innovation and Technology of Ribeirão Preto
2002-2007
Comparative Aircraft Flight Efficiency Foundation
2007
Universidade Estadual Paulista (Unesp)
2007
Clinics Hospital of Ribeirão Preto
1992-2003
Systemic inflammation is a leading cause of hospital death. Mild systemic accompanied by warmth-seeking behavior (and fever), whereas severe associated with cold-seeking hypothermia). Both behaviors are adaptive. Which brain structures mediate which unknown. The involvement hypothalamic structures, namely, the preoptic area (POA), paraventricular nucleus (PVH), or dorsomedial (DMH), in thermoregulatory endotoxin (lipopolysaccharide [LPS])-induced was studied rats. rats were allowed to select...
Abstract Systemic inflammation (SI) is a leading cause of hospital death. Although fever and hypothermia are listed as symptoms in every definition SI, how SI affects thermoregulatory behavior unclear. often modeled by systemic administration bacterial lipopolysaccharide (LPS) to rats. When rats not allowed regulate their body temperature (T b ) behaviorally, LPS causes either or hypothermia, the direction response determined dose ambient ). However, many studies which were T behaviorally...
Our hypothesis is that oxytocin (OT) causes natriuresis by activation of renal NO synthase releases followed cGMP mediates the natriuresis. To test this hypothesis, an inhibitor synthase, l -nitroarginine methyl ester (NAME), was injected into male rats. Blockade release NAME had no effect on induced atrial natriuretic peptide (ANP). This presumably caused because ANP also activates guanylyl cyclase, which synthesizes from GTP. The 18-fold increase in sodium (Na + ) excretion OT (1 μg)...
We examined the magnitude of hypoxic metabolic response in golden-mantled ground squirrels to determine whether shift thermoregulatory set point (T ) and subsequent fall body temperature b rate observed small mammals were greater a species that routinely experiences burrows hibernates. measured effects changing ambient ; 6–29°C) on metabolism (O 2 consumption CO production), T , ventilation, heart normoxia hypoxia (7% O ). The hypoxia-induced falls was larger than other rodents. Metabolic...
We tested the hypothesis that nitric oxide (NO) acts in anteroventral preoptic region (AVPO) modulating fever. To this end, body core temperature (T c ) of rats was monitored by biotelemetry before and after pharmacological modulation NO pathway. Nitrite/nitrate cGMP third ventricular (AV3V), where AVPO is located, were also determined. Intra-AVPO microinjection synthase (NOS) inhibitor N G -monomethyl-l-arginine (l-NMMA, 12.5 μg) did not affect basal T , but it enhanced early stage...
It is known that brain noradrenaline (norepinephrine) mediates fever, but the neuronal group involved unknown. We studied role of major noradrenergic nucleus, locus coeruleus (LC), in lipopolysaccharide (LPS)‐induced fever. Male Wistar rats had their LC completely ablated electrolytically or catecholaminergic neurones selectively lesioned by microinjection 6‐hydroxydopamine; controls were sham‐operated. Both lesions resulted a marked attenuation LPS (1 10 μg kg −1 , i.v. ) fever at...
There is evidence that serotonin [5-hydroxytryptamine (5-HT)] involved in the physiological responses to hypercapnia. Serotonergic neurons represent major cell type (comprising 15-20% of neurons) raphe magnus nucleus (RMg), which a medullary nucleus. In present study, we tested hypothesis 1) RMg plays role ventilatory and thermal hypercapnia, 2) serotonergic are these responses. To this end, microinjected ibotenic acid promote nonspecific lesioning RMg, or anti-SERT-SAP (an immunotoxin...
Lipopolysaccharide (LPS)-induced systemic inflammation (SI) is associated with neuroinflammation in the brain, hypotension, tachycardia, and multiple organs dysfunctions. Considering that during SI these important cardiovascular inflammatory changes take place, we measured sensitivity of reflexes baroreflex, chemoreflex, Bezold-Jarisch are key regulators hemodynamic function. We also evaluated nucleus tractus solitarius (NTS), first synaptic station integrates peripheral signals arising from status.
Rationale: Obstructive sleep apnea is recurrent upper airway obstruction caused by a loss of muscle tone during sleep. The main goal our study was to determine if designer receptors exclusively activated drugs (DREADD) could be used activate the genioglossus as potential novel treatment strategy for apnea. We have previously shown that prototypical DREADD ligand clozapine-N-oxide increased pharyngeal diameter in mice expressing hypoglossal nucleus. However, need direct brainstem viral...
Hydrogen sulfide (H(2)S) is a gaseous neuromodulator endogenously produced in the brain by enzyme cystathionine β-synthase (CBS). We tested hypothesis that H(2)S acts within anteroventral preoptic region of hypothalamus (AVPO) modulating production prostaglandin (PG) E(2) (the proximal mediator fever) and cyclic AMP (cAMP). To this end, we recorded deep body temperature (Tb) rats before after pharmacological modulation CBS-H(2)S system combined or not with lipopolysaccharide (LPS) exposure,...
Abstract Defensive responses are neurophysiological processes crucial for survival during threatening situations. immobility is a common adaptive response, in rodents, elaborated by ventrolateral periaqueductal gray matter (vlPAG) when threat unavoidable. It associated with somatosensory and autonomic reactions such as alteration the sensation of pain rate respiration. In this study, defensive was assessed chemical stimulation vlPAG different doses NMDA (0.1, 0.3, 0.6 nmol). After...
Hypothermia is a response to hypoxia that occurs in organisms ranging from protozoans mammals, but very little known about the mechanisms involved. Recently, NO pathway has been suggested be involved thermoregulation. In present study, we assessed participation of nitric oxide hypoxia-induced hypothermia by means synthase inhibition using NG-nitro-L-arginine methyl ester (L-NAME). The rectal temperature awake, unrestrained rats was measured before and after or L-NAME injection both...