A5061939836- Neurobiology and Insect Physiology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 Clinical Research Studies
- Olfactory and Sensory Function Studies
- Neurogenesis and neuroplasticity mechanisms
- Long-Term Effects of COVID-19
- Zebrafish Biomedical Research Applications
- Cell Image Analysis Techniques
- Radiopharmaceutical Chemistry and Applications
- Single-cell and spatial transcriptomics
- Neuroendocrine Tumor Research Advances
- Radiation Therapy and Dosimetry
Université Laval
2021-2023
Institut Universitaire en Santé Mentale de Québec
2020
Coronavirus disease 19 (COVID-19) is a respiratory illness caused by severe acute syndrome coronavirus-2 (SARS-CoV-2). COVID-19 pathogenesis causes vascular-mediated neurological disorders via elusive mechanisms. SARS-CoV-2 infects host cells the binding of viral Spike (S) protein to transmembrane receptor, angiotensin-converting enzyme 2 (ACE2). Although brain pericytes were recently shown abundantly express ACE2 at neurovascular interface, their response S still be elucidated. Using...
Targeted radionuclide therapy (TRT) is gaining importance. For TRT to be also used as adjuvant or for treating minimal residual disease, there a need increase the radiation dose small tumours. The aim of this in silico study was compare performances 161Tb (a medium-energy β- emitter with additional Auger and conversion electron emissions) 177Lu irradiating single tumour cells micrometastases, various distributions radionuclide.We Monte Carlo track-structure (MCTS) code CELLDOSE compute doses...
Abstract The morpho-functional properties of neural networks constantly adapt in response to environmental stimuli. olfactory bulb is particularly prone constant reshaping because ongoing neurogenesis. It remains unclear whether the complexity distinct odor-induced learning paradigms and sensory stimulation induces different forms structural plasticity. In present study, we automatically reconstructed spines 3D from confocal images performed unsupervised clustering based on morphometric...
Neuronal migration is a highly dynamic process, and multiple cell movement metrics can be extracted from time-lapse imaging datasets. However, these parameters alone are often insufficient to evaluate the heterogeneity of neuroblast populations. We developed an analytical pipeline based on reducing dimensions dataset by principal component analysis (PCA) determining sub-populations using k-means, supported elbow criterion method validated decision tree algorithm. showed that neuroblasts...
Abstract COVID-19 is a respiratory disease caused by severe acute syndrome coronavirus-2 (SARS-CoV-2). pathogenesis causes vascular-mediated neurological disorders via still elusive mechanisms. SARS-CoV-2 infects host cells binding to angiotensin-converting enzyme 2 (ACE2), transmembrane receptor that recognizes the viral spike (S) protein. Brain pericytes were recently shown express ACE2 at neurovascular interface, outlining their possible implication in microvasculature injury COVID-19....
Abstract During development and in adulthood the morpho-functional properties of neural networks constantly adapt response to environmental stimuli learned experiences. One processes that allows neuronal be reshaped is synaptic plasticity, which induced sensory experience learning. Synaptic plasticity for formation/elimination connections as well strengthening pre-existing ones. The olfactory system particularly prone constant reshaping rewiring throughout lifespan an animal, mainly because...