A5101350986- PARP inhibition in cancer therapy
- Semiconductor materials and interfaces
- Calcium signaling and nucleotide metabolism
- Silicon and Solar Cell Technologies
- Neurological disorders and treatments
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Semiconductor Lasers and Optical Devices
- Parkinson's Disease Mechanisms and Treatments
- Organic Light-Emitting Diodes Research
- GaN-based semiconductor devices and materials
- Adenosine and Purinergic Signaling
- Nuclear Receptors and Signaling
- Protein Degradation and Inhibitors
- Thin-Film Transistor Technologies
Nantong University
2024
Chinese Academy of Sciences
2024
The University of Texas Southwestern Medical Center
2021-2024
Institute of Chemistry
2024
Peking University Shenzhen Hospital
2021
China Medical University
2021
Lund University
2021
Abstract Cyclic GMP–AMP synthase (cGAS), a cytosolic DNA sensor that initiates STING-dependent innate immune response, binds tightly to chromatin, where its catalytic activity is inhibited; however, mechanisms underlying cGAS recruitment chromatin and functions of chromatin-bound (ccGAS) remain unclear. Here we show mTORC2-mediated phosphorylation human serine 37 promotes localization in colorectal cancer cells, regulating cell growth drug resistance independently STING. We discovered ccGAS...
Small‐size pixels and high efficiency under low injection levels are required for high‐resolution microdisplay. Efficient blue InGaN micro‐light‐emitting diodes (μLEDs) with 5 μm diameter fabricated using AuSn flip‐chip bonding, reflection electrodes, large‐area N electrodes surrounding the mesas. The peak external quantum (EQE) measured in an integrating sphere is as 13.67% at a current density of 5.4 A cm −2 . Moreover, 0.1 , EQE can still reach 11.69%. electrical approaches 1,...
Optimally designed silver–silicon (Ag–Si) contacts, based on silver (Ag) paste screen printing and the rapid sintering process, are widely utilized in mainstream crystalline silicon solar cells, enabling to reduce contact resistance high photo‐conversion efficiency. Ag powder is largest conductive component paste, but its impact formation of Ag–Si contacts lacks in‐depth research comprehensive understanding. In this work, it demonstrated that oxygen adsorption capacity powders affects by...
Abstract Background: Growing evidence suggest the association between Parkinson’s disease (PD) and diabetes mellitus (DM). On a cellular level, it was proven that long-term elevated levels of glucose might lead to nigrostriatal degeneration in PD models. However, underlying mechanism is still unclear. Previously, we have elucidated potential type 2 (T2DM) facilitating progression, involving aggregation both alpha-synuclein (α-syn) islet amyloid polypeptide (IAPP) pancreatic brain tissues....
Abstract The depletion of NAD is intimately linked to neurodegenerative diseases and aging. Excessive activation + -consuming enzymes that hydrolyze ADP-ribose nicotinamide closely related diseases. However, supplementation or its precursors failed show any benefits for most patients. molecular mechanisms underlying this are largely undefined. Here we ADP-ribose, as an endogenous metabolite, triggers neuronal cell death by glutathione-independent ferroptosis. cells in both the hippocampus...