A5003942281- Immune Response and Inflammation
- Orthopedic Infections and Treatments
- Immune cells in cancer
- COVID-19 Clinical Research Studies
- Advanced Proteomics Techniques and Applications
- Extracellular vesicles in disease
- Molecular Biology Techniques and Applications
- Long-Term Effects of COVID-19
- Metabolism and Genetic Disorders
- Nanoplatforms for cancer theranostics
- Immune responses and vaccinations
- Mosquito-borne diseases and control
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Vitamin C and Antioxidants Research
- Sepsis Diagnosis and Treatment
- Virus-based gene therapy research
- Youth, Drugs, and Violence
- Intensive Care Unit Cognitive Disorders
- Neonatal Respiratory Health Research
- Glycosylation and Glycoproteins Research
- Health and Lifestyle Studies
Universidade de São Paulo
2024
Universidade Cruzeiro do Sul
2020-2023
We measured plasma-derived extracellular vesicle (EV) proteins and their microRNA (miRNA) cargos in normoglycemic (NG), glucose intolerant (GI), newly diagnosed diabetes mellitus (DM) middle-aged male participants of the Brazilian Longitudinal Study Adult Health (ELSA-Brazil). Mass spectrometry revealed decreased IGHG-1 increased ITIH2 protein levels GI group compared with that NG higher serotransferrin EVs DM than those groups. The also showed serum ferritin levels, as evaluated by...
Diabetes is associated with a worse prognosis and high risk of morbidity mortality in COVID-19 patients. We aimed to evaluate the main factors involved poor diabetic A total 984 patients diagnosed admitted hospital were included this study. Patients first divided into type-2 (DM+) non-diabetic (DM-) groups. The participants analyzed based on National Early Warning Score (NEWS) Quick-Sequential Organ Failure Assessment (qSOFA) find best prognostic score for our DM+ DM- groups non-severe...
OBJECTIVES: This study sought to identify monocyte alterations from septic patients after hospital discharge by evaluating gene expression of inflammatory mediators and polarization markers. It was hypothesized that sepsis reprograms the state monocytes, causing effects persist influencing patient outcomes. DESIGN: The patterns receptors, M1 M2 macrophage markers, NLRP3 inflammasome components, pro- anti-inflammatory cytokines in monocytes were assessed. PATIENTS: Thirty-four University São...
We determined the prevalence of metabolic syndrome (MetS) among military police officers (MPOs) from radio patrol program Military Police Sao Paulo State (PMESP). Towards this goal, we analyzed following characteristics: shift duty (daytime or nighttime patrol), service length in PMESP, education level attained, weekly alcohol consumption, smoking, and physical activity 93 MPOs. The MPO groups were created based on work [daytime (n=48) (n=45)], years experience [≤3 ≥10 (n=45)]. overall MetS...
Sepsis is a life-threatening condition with high hospital mortality. Elevated mortality has also been observed in patients after discharge due to post-sepsis syndrome (PSS). The etiology of PSS still not entirely known, but it involves inflammation. Plasma extracellular vesicles (EVs) are recognized as unique mechanism intercellular communication inflammatory processes. It reported that EV microRNA (miRNA) production during the acute sepsis phase may persist until disease resolution and...
The extracellular matrix (ECM) comprises macromolecules that shape a complex three-dimensional network. Filling the intercellular space and playing crucial role in structure function of tissues, ECM regulates essential cellular processes such as adhesion, differentiation, cell signaling. In human adrenal gland, composed cortex medulla surrounded by capsule, has not yet been directly described, although its impact on proliferation steroidogenesis is recognized. This study analyzes adult...
Abstract Background : Monocytes and macrophages are essential components of the innate adaptive immune responses play a critical role in sepsis. Sepsis is life-threatening organ dysfunction associated with an unregulated host response to infection. About 20 million people develop sepsis annually, up 50% die. There lack studies regarding human monocytes This study aimed determine most stable internal gene (s) investigate expression monocytes/macrophages septic patients. Methods The stability...
Abstract Background: Sepsis is a life-threatening organ dysfunction associated with unregulated host response to infection. About 20 million people develop sepsis annually, and up 50% die. Monocytes macrophages play key role in the innate adaptive immune responses but fully of these cells patients still remains be investigated. One limitations for studies gene expression monocytes/macrophages choice reference genes. We determined herein most stable internal (s) investigate expressions septic...