A5059133151- Advanced Polymer Synthesis and Characterization
- Diabetes and associated disorders
- biodegradable polymer synthesis and properties
- Polymer Surface Interaction Studies
- Nanoparticle-Based Drug Delivery
- Pancreatic function and diabetes
- Graphene and Nanomaterials Applications
- Diabetes Management and Research
- Genetics and Neurodevelopmental Disorders
- Conducting polymers and applications
Université Paris-Saclay
2023-2024
Centre National de la Recherche Scientifique
2024
Institut Galien Paris-Saclay
2022-2023
McGill University
2020-2022
Université de Montréal
2022
Vinyl polymers are the focus of intensive research due to their ease synthesis and possibility making well-defined, functional materials. However, non-degradability leads environmental problems limits use in biomedical applications, allowing aliphatic polyesters still be considered as gold standards. Radical ring-opening polymerization cyclic ketene acetals is most promising approach impart degradability vinyl polymers. these materials exhibit poor hydrolytic degradation thus cannot yet...
Despite their great versatility and ease of functionalization, most polymer-based nanocarriers intended for use in drug delivery often face serious limitations that can prevent clinical translation, such as uncontrolled release off-target toxicity, which mainly originate from the burst phenomenon. In addition, residual solvents formulation process induce alter physico-chemical biological properties strongly impair further pharmaceutical development. To address these issues, we report polymer...
Islet transplantation offers a long-term cure for Type 1 Diabetes (T1D), freeing patients from daily insulin injections. Therapeutic peptides have shown potential to increase the output of pancreatic islets, maximizing impact grafted cells. The islet neogenesis-associated protein (INGAP), and its bioactive core (INGAP-P), stimulate beta-cell function viability, offering possibility treatment prior implant. However, dosing efficacy is limited by low circulation time enzyme degradation. This...
Despite their great versatility and ease of functionalization, most polymer-based nanocarriers intended for use in drug delivery often face serious limitations that can prevent clinical translation, such as uncontrolled release off-target toxicity, which mainly originate from the burst phenomenon. In addition, residual solvents formulation process induce alter physico-chemical biological properties strongly impair further pharmaceutical development. To address these issues, we report polymer...
Polymer prodrugs are based on the covalent linkage of therapeutic molecules to a polymer structure which avoids problems and limitations commonly encountered with traditional drug-loaded nanocarriers in drugs just physically entrapped (e.g., burst release, poor drug loadings). In past few years, reversible-deactivation radical polymerization (RDRP) techniques have been extensively used design tailor-made prodrug nanocarriers. This synthesis strategy has received lot attention due possibility...
Type 1 diabetic patients characteristically exhibit a loss of insulin production, leading to chronic hyperglycemia and related complications. Herein we describe the design, synthesis screening novel oligopeptides for their potential enhance secretion from human pancreatic islets. The investigation these compounds, based off patented INGAP-PP sequence, aims identify peptide features key maximizing secretion.Clinical Relevance — This report describes relative efficacy selected compounds...