A5035071030- Pregnancy and preeclampsia studies
- Climate Change and Health Impacts
- Global Public Health Policies and Epidemiology
- Health disparities and outcomes
- COVID-19 and Mental Health
- Maternal and fetal healthcare
- SARS-CoV-2 and COVID-19 Research
- Disaster Management and Resilience
- Pulmonary Hypertension Research and Treatments
- Folate and B Vitamins Research
- Birth, Development, and Health
- Autism Spectrum Disorder Research
- Global Health Care Issues
- Obesity, Physical Activity, Diet
- Diversity and Career in Medicine
- Genetics and Neurodevelopmental Disorders
- Cleft Lip and Palate Research
- Glaucoma and retinal disorders
- Medical Education and Admissions
- Blood Coagulation and Thrombosis Mechanisms
- Virology and Viral Diseases
- Disaster Response and Management
- Hemoglobinopathies and Related Disorders
- Collaborative Teaching and Inclusion
- Cardiovascular Issues in Pregnancy
Liaquat University of Medical & Health Sciences
2019-2025
Bilawal Medical College
2021-2024
Namal College
2021-2024
Abstract Breast cancer (BC) continues to be a significant global challenge due drug resistance and severe side effects. The increasing prevalence is alarming, requiring new therapeutic approaches address these challenges. At this point, Extracellular vesicles (EVs), specifically small endosome-released nanometer-sized EVs (SEVs) or exosomes, have been explored by literature as potential theranostics. Therefore, review aims highlight the of exosomes in BC, focusing on their advantages...
Abstract Background To study the role of single nucleotide variants (SNVs) genes related to preeclampsia in Pakistani pregnant women. Methods After ethical approval and getting informed consent; 250 women were enrolled equally divided into two groups (125 preeclamptic cases 125 normotensive women). Demographic details medical history recorded, 10 ml blood sample was obtained for DNA extraction. The tetra-primer amplification refractory mutation system (ARMS) assays developed assessing three...
Objective: To find out the association of physical activity, dietary habits and factors associated with depression among medical students Sindh, Pakistan, during coronavirus disease 2019 (COVID-19) pandemic. Methods: An online cross-sectional study was conducted between June August, 2020, on from three institutions Pakistan. The comprised structured questionnaires related to demographic details, sleep habits, COVID-19 pandemic-associated patient health questionnaire, PHQ-9. A total 864...
Objectives Hemoglobinopathies are prevalent monogenic disorders resulting from genetic abnormalities in globin genes, significantly impacting health. β-thalassemia is particularly common Pakistan, but data on other hemoglobin variants remain limited. This study aimed to investigate HbD syndrome, identify unknown variants, and examine the clinicohematological molecular profiles of hemoglobinopathies Sindh, Pakistan. Methods A prospective cross-sectional was conducted January 2021 2023 at...
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental influenced by genetic and environmental factors. This study examined the specific gene variants, dopamine transporter 1 (DAT1) rs6350, receptor D3 (DRD3) rs6280, D2 (DRD2) rs6277, catechol-O-methyltransferase (COMT) rs4633, in relation to ADHD among Pakistani children exploring potential gene-gene gene-environment interactions.
To determine the levels of angiogenic biomarkers: vascular endothelial growth factor (VEGF), soluble receptor 1 (sVEGFR1 or sFlt-1), platelet count, and VEGF/platelet ratio in preeclampsia.
To find out the association of secreted protein acidic and rich in cysteine (SPARC)-related modular calcium binding 2 (
Pre-eclampsia is a hypertensive pregnancy disorder accompanied by proteinuria. Serum Lactate Dehydrogenase (LDH) biochemical marker that reflects the severity and progression of pre-eclampsia.A cross-sectional study was conducted at Liaquat University Medical Health Sciences (LUMHS). One hundred pre-eclamptic women were enrolled categorized into mild (n=30) severe groups (n=70) to ascertain function LDH as prognostic assess its association with gestational age in women.The significant...
Preeclampsia is multi-systemic hypertensive pregnancy disorder accompanied by proteinuria.To determine the frequency of different presentations preeclampsia in tertiary care hospital and find out its risk factors.The present study was hospital-based cross-sectional conducted from 1st August 2015 to 31st July 2016 Gynaecology Obstetrics Department, Liaquat University Medical Health Sciences (LUMHS), Hyderabad after ethical approval. A total 112 pre-eclamptic women were enrolled during period...
Postcoital bleeding increases the chance of detecting cervical dysplasia and cancer; Pap smear is recommended screening test in these patients. We conducted a cross-sectional study that included 110 women to find out frequency abnormal such Their age range was 15–65 years with mean 31.2 ± 11.2 years. Abnormal found 54 (49%) women. Atypical squamous cells unknown significance (ASCUS) were 13.6%, low-grade intraepithelial lesion (LSIL) 20.9%, high-grade (HSIL) 11.8% carcinoma 2.7% those....
Upper gastrointestinal malignancies are a major global health burden. Early diagnosis of upper premalignant and malignant lesions is crucial for improving prognosis reducing morbidity mortality. The purpose this study was to investigate the diagnostic accuracy confocal laser endomicroscopy (CLE) in detecting early high-risk patients, as well diagnosing patients with inconclusive white light endoscopy (WLE) histopathology results.It cross-sectional that included ninety (n = 90) diagnoses on...
This study investigated the association of
The objectives of this study were to determine the association methylenetetrahydrofolate reductase (MTHFR) gene variant C677T with non-syndromic cleft lip/palate (NSCLP) in Pakistani population and compare maternal serum folic acid levels NSCLP-affected healthy group. A comparative cross sectional was conducted between 2017 2019 at Liaquat University Medical Health Sciences, Jamshoro. Sixty mother-infant dyads recruited (n = 120), including infants along their mothers. MTHFR exhibited...
Abstract A cross-sectional, mixed-method study was conducted in Badin, a rural area southern Sindh, which is considered high-risk disaster zone, to assess the vulnerability, preparedness, and experiences of coastal population. multistage sampling technique employed select villages, area, 3 distinct populations (I, II, III). Family heads households were recruited for population I, village community support group leaders from selected clusters III. The survey through face-to-face interviews....
OBJECTIVE:To identify the pathogenic alleles in primary congenital glaucoma patients for early cure of disease METHODOLOGY: A cross-sectional descriptive study was carried out after approval from ethical committee SIOVS December 2022 to 2023 at Sindh Institute Ophthalmology & Visual Sciences, Hyderabad.The consanguineous pedigree consisting more than one affected included, and consists only or secondary cause vision loss excluded.After getting informed consent, ten cc blood samples all...
The SARS-CoV-2 virus, responsible for the COVID-19 pandemic, has continuously evolved since its emergence. Among variants, Omicron lineage become globally dominant, displaying a diverse range of sublineages. Two significant sub lineages within are EG.5 and BA.2.8, which have gained attention due to their unique characteristics potential implications. is characterized by constellation mutations, including N501Y, L452R, D614G. Similarly, BA.2.8 carries L452Q P681R enhance ability evade...
The SARS-CoV-2 virus, responsible for the COVID-19 pandemic, has continuously evolved since its emergence. Among variants, Omicron lineage become globally dominant, displaying a diverse range of sublineages. Two significant sub lineages within are EG.5 and BA.2.8, which have gained attention due to their unique characteristics potential implications. is characterized by constellation mutations, including N501Y, L452R, D614G. Similarly, BA.2.8 carries L452Q P681R enhance ability evade...
Coronaviruses, a family of enveloped RNA viruses, have been implicated in various clinical disorders including coronavirus disease 2019 (COVID-19). Host genetic factors, the OAS1 and MxA gene variants may role determining susceptibility to viral infections. Understanding factors involved unraveling COVID-19`s diverse outcomes is critical for management. This study investigated impact rs2660 rs2071430 genotypes on COVID-19 severity among Pakistani patients.
In Pakistan, the incidence rate of aplastic anemia is 3.5 cases/million. The associated risk factors are exposure to pesticides, chemicals, and some drugs. link between socio-demographic debatable.We conducted this study investigate role socio-economic -demographic with anemia.A total 191 lab-confirmed incident cases were identified from tertiary hospital Karachi-Pakistan in 2015 2018. Age gender-matched 694 controls randomly selected same institute admitted or visited for other...