A5101842374- Extracellular vesicles in disease
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- Cardiac Fibrosis and Remodeling
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bone health and osteoporosis research
- Cardiovascular Effects of Exercise
- Kruppel-like factors research
- Renal Transplantation Outcomes and Treatments
- Metabolism and Genetic Disorders
- Hip and Femur Fractures
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
Chinese PLA General Hospital
2020-2024
Nanjing University of Chinese Medicine
2024
Kunming Medical University
2013-2021
Albert Einstein College of Medicine
2019
Guangdong General Hospital
2010
The inclusion of microRNAs (miRNAs) in extracellular microvesicles/exosomes (named cardiosomes when deriving from cardiomyocytes) allows their active transportation and ensures cell-cell communication. We hypothesize that cardiosomal miRNAs play a pivotal role the activation myofibroblasts following ischemic injury. Using murine model myocardial infarction (MI), we tested our hypothesis by measuring isolated fibroblasts expression levels set miRNAs, which are upregulated cardiomyocytes...
Biological scaffolds based stem cell delivery methods have emerged as a promising approach for tissue repair and regeneration. Here we developed hydrogel biological scaffold from human decellularized adipose matrix (hDAM) adipose-derived cells (hASCs) to accelerate chronic wound healing. The hDAM was prepared by pepsin mediated digestion pH controlled neutralization. morphology, survival, proliferation, angiogenic paracrine activity of hASCs cultured in the were assessed. Moreover,...
Our work aimed to investigate the interactive roles of transforming growth factor β1 (TGF-β1), ubiquitin-specific-processing protease 7 (USP7), and Yes-associated protein (YAP) in ferroptosis during sepsis-secondary acute lung injury (ALI). study demonstrated that was aggravated by TGF-β1 both cellular animal models injury. Additionally, YAP upregulated glutathione peroxidase 4 (GPX4) SLC7A11 regulating binding TEAD4 GPX4/SLC7A11 promoters. Furthermore, large tumor suppressor kinase 1...
Background: The inclusion of microRNAs (miRNAs) in extracellular microvesicles/exosomes (named cardiosomes when deriving from cardiomyocytes) allows their active transportation and ensures cell-cell communication. Aim: We hypothesize that cardiosomal miRNAs play a pivotal role the activation myofibroblasts following ischemic injury. Methods: Using bioinformatic approaches an established murine model myocardial infarction (MI, achieved via ligation left anterior descending coronary artery),...
Abstract Background Circulating microRNAs (miRNAs) are actively transported, via inclusion in extracellular microvesicles/exosomes (herein named cardiosomes since they deriving from cardiomyocytes), allowing protection degradation and underlying cell-cell communications. After myocardial infarction (MI), quiescent cardiac fibroblasts can acquire an activated phenotype, a recognized marker of such activation is the expression α-smooth muscle actin (α-SMA); cells commonly known as...