Shixiang Zhai

ORCID: 0000-0003-0333-7445
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About
Contact & Profiles
Research Areas
  • Gut microbiota and health
  • Diet and metabolism studies
  • Genomics and Phylogenetic Studies
  • Bacteriophages and microbial interactions
  • Clostridium difficile and Clostridium perfringens research
  • Barrier Structure and Function Studies
  • Dietary Effects on Health
  • Geophysics and Gravity Measurements
  • Plant Virus Research Studies
  • Gamma-ray bursts and supernovae
  • Adaptive optics and wavefront sensing
  • Probiotics and Fermented Foods
  • Microbial Metabolites in Food Biotechnology
  • Stellar, planetary, and galactic studies
  • Astrophysical Phenomena and Observations
  • Microbial infections and disease research
  • Ginseng Biological Effects and Applications
  • Astronomy and Astrophysical Research

Chinese Academy of Sciences
2017-2024

Institute of High Energy Physics
2023-2024

University of Chinese Academy of Sciences
2018-2023

Institute of Oceanology
2022

Yantai Institute of Coastal Zone Research
2017-2022

Butyrate, a key metabolite fermented by gut microbiota mainly from undigested carbohydrates such as dietary fibers is widely used feed additive. However, mechanisms of its contributions in maintaining host health are relatively poorly revealed. The aim this study was to investigate how butyrate impacts and immunity response high-fat diet-fed mice. Gut microbial analysis exhibited that intervention increased short-chain fatty acids (SCFAs)-producing bacteria decreased pathogenic bacteria,...

10.1093/femsle/fnz153 article EN FEMS Microbiology Letters 2019-07-01

The study aimed to analyze the global influences of dietary inulin with different degrees polymerization (DP) on intestinal microbial communities. Six-week-old male C57BL/6J mice were treated fructo-oligosaccharides and for 6 weeks. Fecal samples obtained at time point 0 6th week. 16S rRNA sequence analysis was used measure microbiota performed Illumina MiSeq platform. Influences more complex effects than bifidogenic effects, relative abundance butyrate-producing bacteria increased after...

10.1093/femsle/fnx075 article EN FEMS Microbiology Letters 2017-04-11

Abstract Gut microbiota have strong connections with health. Lactulose has been shown to regulate gut and benefit host In this study, the effect of short‐term (3 week) intervention lactulose on was investigated. were detected from mouse feces by 16S rRNA high‐throughput sequencing, short chain fatty acids ( SCFA s) gas chromatography‐mass spectrometry GC ‐ MS ). enhanced α‐diversity microbiota; increased abundance hydrogen‐producing bacteria Prevotellaceae Rikenellaceae, probiotics...

10.1002/mbo3.612 article EN cc-by MicrobiologyOpen 2018-03-24

Abstract The health‐promoting effects of phycocyanin (PC) have become widely accepted over the last two decades. In this study, we investigated different doses PC in modulating intestinal microbiota and barrier mice. Six‐week‐old male C57BL/6 mice were treated with for 28 days. Fecal samples collected before after intervention, analyzed by 16S rRNA high‐throughput sequencing. Bacterial abundance diversity increased intervention. Saccharolytic bacteria families Lachnospiraceae...

10.1002/mbo3.825 article EN cc-by MicrobiologyOpen 2019-03-25

Abstract Temperate phages (active prophages induced from bacteria) help control pathogenicity, modulate community structure, and maintain gut homeostasis. Complete phage genome sequences are indispensable for understanding biology. Traditional plaque techniques inapplicable to temperate due their lysogenicity, curbing identification characterization. Existing bioinformatics tools prophage prediction usually fail detect accurate complete genomes. This study proposes a novel computational...

10.1093/nargab/lqac057 article EN cc-by-nc NAR Genomics and Bioinformatics 2022-07-09

ABSTRACT We present the results of photometric and spectroscopic monitoring campaigns changing look AGN NGC 2617 carried out from 2016 until 2022 covering wavelength range X-ray to near-IR. The facilities included telescopes SAI MSU, MASTER Global Robotic Net, 2.3-m WIRO telescope, Swift, others. found significant variability at all wavelengths and, specifically, in intensities profiles broad Balmer lines. measured time delays ∼6 d (∼8 d) responses Hβ (Hα) line continuum variations....

10.1093/mnras/stad2442 article EN Monthly Notices of the Royal Astronomical Society 2023-08-15

Abstract We present the results of a new X-ray to near-IR photometric and spectroscopic monitoring changing look AGN NGC 2617 carried out from March 2022 2024. found significant variability at all wavelengths in intensities profiles broad Balmer lines. Reverberation mapping was for three observing seasons during 2021-2024. obtained time delays ∼4 d response Hβ line optical continuum variations. The variations correlate well with UV optical, few days lag longer wavelengths. K band lagged B by...

10.1093/mnras/stae2707 article EN cc-by Monthly Notices of the Royal Astronomical Society 2024-12-09

Temperate phages (active prophages induced from bacteria) help control pathogenicity, modulate community structure, and maintain gut homeostasis 1 . Complete phage genome sequences are indispensable for understanding biology. Traditional plaque techniques inapplicable to temperate due the lysogenicity of these phages, which curb identification characterization phages. Existing in silico tools prophage prediction usually fail detect accurate complete genomes 2–5 In this study, by a novel...

10.1101/2021.07.15.452192 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2021-07-15
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