A5006250743- Agricultural pest management studies
- Legume Nitrogen Fixing Symbiosis
- Genetic and Environmental Crop Studies
- Soybean genetics and cultivation
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Folate and B Vitamins Research
- Genetics and Plant Breeding
- Genetic Mapping and Diversity in Plants and Animals
- Liver Disease Diagnosis and Treatment
- Erythropoietin and Anemia Treatment
- Genetic Associations and Epidemiology
University of Exeter
2023-2024
Yahoo (United Kingdom)
2024
Health & Life (Taiwan)
2024
University of California, Riverside
2011-2023
Syngenta (United States)
2019
University of California System
2015
Cowpea (Vigna unguiculata L. Walp.) is a legume crop that resilient to hot and drought-prone climates, primary source of protein in sub-Saharan Africa other parts the developing world. However, genome resources for cowpea have lagged behind most major crops. Here we describe foundational their application analysis germplasm currently use West African breeding programs. Resources developed from cultivar IT97K-499-35 include whole-genome shotgun (WGS) assembly, bacterial artificial chromosome...
Cowpea [ Vigna unguiculata (L.) Walp.] is a major tropical legume crop grown in warm to hot areas throughout the world and especially important people of sub‐Saharan Africa where was domesticated. To date, relatively little understood about its domestication origins patterns genetic variation. In this study, worldwide collection cowpea landraces African ancestral wild genotyped with more than 1200 single nucleotide polymorphism markers. Bayesian inference revealed presence two gene pools...
Linkage mapping is relevant to modern plant biology and provides a framework for downstream analyses including quantitative trait loci identification, map-based cloning, assessment of diversity, association mapping, molecular breeding. Here, we report consensus genetic map cowpea [Vigna unguiculata (L.) Walp.] synteny other legumes based on expressed sequence tag (EST)-derived single nucleotide polymorphisms (SNPs). In total, 1293 individuals representing 13 populations were genotyped using...
The cowpea aphid Aphis craccivora Koch (CPA) is a destructive insect pest of cowpea, staple legume crop in Sub-Saharan Africa and other semiarid warm tropics subtropics. In California, CPA causes damage on all local cultivars from early vegetative to pod development growth stages. Sources resistance are available African germplasm. However, their utilization breeding limited by the lack information inheritance, genomic location marker linkage associations determinants. research reported...
Genome resolution of a major QTL associated with the Rk locus in cowpea for resistance to root-knot nematodes has significance plant breeding programs and R gene characterization. Cowpea (Vigna unguiculata L. Walp.) is susceptible host (Meloidogyne spp.) (RKN), plant-parasitic pests global agriculture. To date, relied on phenotypic selection which requires time-consuming expensive controlled infection assays. facilitate marker-based selection, we aimed identify map quantitative trait loci...
Objectives HFE haemochromatosis genetic variants have an uncertain clinical penetrance, especially to older ages and in undiagnosed groups. We estimated p.C282Y p.H63D variant cumulative incidence of multiple outcomes a large community cohort. Design Prospective cohort study. Setting 22 assessment centres across England, Scotland, Wales the UK Biobank (2006–2010). Participants 451 270 participants genetically similar 1000 Genomes European reference population, with mean 13.3-year follow-up...
The appearance of the seed is an important aspect consumer preference for cowpea (Vigna unguiculata [L.] Walp.). Seed coat pattern in has been a subject study over century. This makes use newly available resources, including mapping populations, reference genome and additional assemblies, high-density single nucleotide polymorphism genotyping platform, to map various traits three loci, concurrent with Color Factor (C), Watson (W), Holstein (H) factors identified previously. Several gene...
Background Brain iron in specific subcortical regions increases risk of dementia and Parkinson's Disease (PD). Genetic environmental factors affect deposition, but the underlying mechanisms are unclear. Objective Identify diseases associated with brain iron, assess causality using genetics. Methods 41,581 UK Biobank participants had MRI-estimated four or PD-associated (Caudate, Putamen, Substantia Nigra, Thalamus). We investigated common (including adiposity, blood pressure, health...
Highly specific seed market classes for cowpea and other grain legumes exists because is most commonly cooked consumed whole. Size, shape, color, texture are critical features of these breeders target development cultivars acceptance. Resistance to biotic abiotic stresses that absent from elite breeding material often introgressed through crosses landraces or wild relatives. When made between parents with different quality characteristics, recovery progeny acceptable enhanced problematic....
The HFE p.C282Y+/+ (homozygous) genotype and central adiposity both increase liver disease diabetes risks, but combined effects are unclear. We estimated waist-to-hip ratio (WHR) associations with incident clinical outcomes in routine care participants the UK Biobank community cohort.
Abstract Introduction HFE genetic variants, especially C282Y homozygosity (C282Y+/+), can increase systemic iron and cause hemochromatosis, though expression varies. Excess lead to liver disease/cancer, yet factors influencing beyond genotype remain unclear. We investigated genetic/environmental iron, including hemochromatosis diagnosis. Methods analysed 37,287 European ancestry UK Biobank participants (mean age 64.1, SD 7.6) with genotypes MRI-estimated concentrations (MRLIC). Linear...
ABSTRACT Molecular assisted breeding is currently constrained by the lack of breeder‐friendly trait‐associated markers, especially among lesser studied crops. Recent advances in genomic technology are being applied to many important crop species, promoting development robust marker–trait associations. Regions cowpea [ Vigna unguiculata (L.) Walp.] genome controlling quantitative resistance feeding foliar thrips ( Thrips tabaci and Frankliniella schultzei ) were tagged coupling phenotypic...
Seed size distinguishes most crops from their wild relatives and is an important quality trait for the grain legume cowpea. In order to breed cowpea varieties with larger seeds we introgressed a rare haplotype associated large at Css-1 locus African buff seed type cultivar, IT82E-18 (18.5 g/100 seeds), into blackeye CB27 (22 seed). Four recombinant inbred lines derived these two parents were chosen marker-assisted breeding based on SNP genotyping goal of stacking haplotypes background....
SUMMARY Cowpea ( Vigna unguiculata L. Walp.) is a legume crop that resilient to hot and drought-prone climates, primary source of protein in sub-Saharan Africa other parts the developing world. However, genome resources for cowpea have lagged behind most major plants. Here we describe foundational their application analysis germplasm currently use West African breeding programs. Resources developed from cultivar IT97K-499-35 include bacterial artificial chromosome (BAC) libraries BAC-based...
The logistics associated with a modern breeding program can be complex, relying on accuracy and communication between plant breeders, pathologists, quantitative geneticists, support staff. International academic facets may bring additional challenges to already error prone activities including the development, maintenance, distribution of lines. Furthermore, practices such as bulking seed maintenance within‐accession variation among landraces must considered when pursuing marker‐assisted...
Abstract Background Accurate genetic maps are the cornerstones of discovery, but their construction can be hampered by missing parental genotype information. Inference haplotypes and correction phase errors done manually on a one basis with aide current software tools, this is tedious time consuming for high marker density datasets currently being generated many crop species. Tools that help automate process inferring genotypes greatly speed map building. We developed tool infers outputs...
Abstract The appearance of the seed is an important aspect consumer preference for cowpea ( Vigna unguiculata [L.] Walp.). Seed coat pattern in has been a subject study over century. This makes use newly available resources, including mapping populations, reference genome and additional assemblies, high-density single nucleotide polymorphism genotyping platform, to map various traits three loci, concurrent with Color Factor C ), Watson W Holstein H ) factors identified previously. Several...
Abstract Objectives HFE haemochromatosis genetic variants have an uncertain clinical penetrance, especially to older ages and in undiagnosed groups. We estimated p.C282Y p.H63D variant cumulative incidence of multiple outcomes a large community cohort. Design Prospective cohort study. Setting 22 assessment centres across England, Scotland, Wales the UK Biobank (2006-2010). Participants 451,270 participants genetically similar 1000-Genomes European reference population, with mean 13.3-year...