A5016736327- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Air Quality and Health Impacts
- Health, Environment, Cognitive Aging
- Climate Change and Health Impacts
- Energy and Environment Impacts
- Environmental Justice and Health Disparities
- Neonatal Respiratory Health Research
- Diet and metabolism studies
- Childhood Cancer Survivors' Quality of Life
- Ultrasound in Clinical Applications
- Health disparities and outcomes
- Frailty in Older Adults
- Gun Ownership and Violence Research
- Dialysis and Renal Disease Management
- Patient Satisfaction in Healthcare
- Intergenerational Family Dynamics and Caregiving
- Healthcare cost, quality, practices
- Folate and B Vitamins Research
- Public Health Policies and Education
- Healthcare Systems and Reforms
- Cancer Genomics and Diagnostics
- Radiation Dose and Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare Policy and Management
University of Pennsylvania
2024-2025
Center for Health Justice
2025
California University of Pennsylvania
2025
Stanford Medicine
2023-2024
Emory University
2021-2024
Georgia Department of Public Health
2021-2024
Federal Reserve
2024
University of California, Berkeley
2020-2022
Harvard University
2013-2022
John F. Kennedy University
2021
// Cavin K. Ward-Caviness 1 , Jamaji C. Nwanaji-Enwerem 2 Kathrin Wolf Simone Wahl 1,3 Elena Colicino 4 Letizia Trevisi 5 Itai Kloog 6 Allan Just 7 Pantel Vokonas 8 Josef Cyrys Christian Gieger Joel Schwartz Andrea A. Baccarelli Alexandra Schneider and Annette Peters Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Bavaria, Germany Department Environmental Health, Harvard T.H. Chan School Public Boston, MA, USA 3 Research Unit Molecular Epidemiology, Health Sciences,...
After the emergence of respiratory virus SARS-CoV-2 (COVID-19), many exposure and environmental health scientists promptly recognized potentially catastrophic public ramifications concurrent infectious air pollution-mediated disease. Nevertheless, much this attention has been focused on outdoor interactions. Each year, 3.8 million people worldwide prematurely die from illnesses attributable to indoor air. Hence, poor household quality is a long-standing issue with even greater relevance now...
A World Health Organization (WHO) and International Labour (ILO) systematic review reported sufficient evidence for higher risk of non-melanoma skin cancer (NMSC) amongst people occupationally exposed to solar ultraviolet radiation (UVR). This article presents WHO/ILO Joint Estimates global, regional, national subnational occupational exposures UVR 195 countries/areas the regional attributable burdens NMSC 183 countries, by sex age group, years 2000, 2010 2019. We calculated...
Ambient particles have been shown to exacerbate measures of biological aging; yet, no studies examined their relationships with DNA methylation age (DNAm-age), an epigenome-wide based predictor chronological age.We the relationship DNAm-age fine particulate matter (PM2.5), a measure total inhalable particle mass, and black carbon (BC), from vehicular traffic.We used validated spatiotemporal models generate 1-year PM2.5 BC exposure levels at addresses 589 older men participating in VA...
Exploring the associations of air pollution and weather variables with blood leukocyte distribution is critical to understand impacts environmental exposures on human immune system.As previous analyses have been mainly based data from cell counters, which might not be feasible in epidemiologic studies including large populations long-stored samples, we aimed expand understanding this topic by employing estimated DNA methylation profiles.We measured profiles samples using Illumina...
<h3>Importance</h3> Elevated intraocular pressure is a major risk factor for glaucoma, leading cause of irreversible blindness worldwide. Environmental air pollution has been suggested as potential contributor to elevated pressure; however, no studies have demonstrated such an association date. <h3>Objective</h3> To investigate the long-term ambient black carbon exposure with in community-dwelling older adults. <h3>Design, Setting, and Participants</h3> This population-based analysis,...
Emerging research suggests associations of physical and psychosocial stressors with epigenetic aging. Although this work has included early-life exposures, data on maternal exposures aging their children remain sparse. Using longitudinally collected from the California, Salinas Valley CHAMACOS study, we examined relationships between Adverse Childhood Experiences (ACEs) reported up to 18 years life, prior pregnancy, eight measures (Horvath, Hannum, SkinBloodClock, Intrinsic, Extrinsic,...
Population aging is a looming global health challenge.New biological metrics based on DNA methylation levels have been developed in addition to traditional biomarkers.The prospective relationships of biomarkers with mitochondrial changes are still not well understood.Here, we examined the associations copy number (mtDNAcn) several -DNAm-Age, DNAm-PhenoAge, DNAm-GrimAge, and leukocyte telomere length.We analyzed 812 individuals from Veteran Affairs Normative Aging Study (NAS) available blood...
In June 2020, the National Academies of Sciences, Engineering, and Medicine hosted a virtual workshop focused on integrating science aging environmental health research. The concurrent COVID-19 pandemic national attention racism exposed shortcomings in research field's conceptualization methodological use race, which have subsequently hindered ability to address racial disparities. By workshop's conclusion, authors deduced that utility biomarkers-aging biomarkers shown be specifically...
One-carbon metabolism (OCM), a biochemical pathway dependent on micronutrients including folate and vitamin B12, plays an essential role in aging-related physiological processes. DNA methylation-based aging biomarkers may be influenced by OCM. This study investigated associations of OCM-related with epigenetic the National Health Nutrition Examination Survey (NHANES). Blood methylation was measured adults aged ≥50 years 1999-2000 2001-2002 cycles NHANES. The following were included:...
Epigenetic clocks can serve as pivotal biomarkers linking environmental exposures with biological aging. However, research on the influence of epigenetic aging has largely been limited to a small number chemicals and specific populations. We harnessed data from National Health Nutrition Examination Survey 1999-2000 2001-2002 cycles examine exposome-wide associations between A total 8 were obtained whole blood in 2,346 participants ranging 50-84 years age. 64 including phthalates, metals,...
Abstract Reproductive aging, including timing of menarche and menopause, influences long-term morbidity mortality in women, yet underlying biological mechanisms remain poorly understood. Using DNA methylation-based biomarkers, we assessed associations age at ( N = 1,033) menopause 658) with epigenetic aging a nationally representative sample women ≥ 50 years. Later was associated lower GrimAge deviation $$B$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>B</mml:mi>...
ABSTRACT Introduction Military service can significantly impact human health, with research showing that veterans experience higher mortality rates than the general population. However, limited data exist on relationships of veteran status biomarkers aging may precede clinical illness and mortality. Methods Using survey-design weighted generalized linear regression models, we examined cross-sectional relationship self-reported DNA methylation (DNAm)-based (epigenetic age) in a representative...
Astronauts undertaking long-duration space missions may be vulnerable to unique stressors that can impact human aging. Nevertheless, few studies have examined the relationship of mission duration with DNA-methylation-based biomarkers aging in astronauts. Using data from six participants Mars-500 mission, a high-fidelity 520-day ground simulation experiment, we tested relationships five longitudinally measured blood metrics: DNAmGrimAge, DNAmPhenoAge, estimator telomere length (DNAmTL),...
Abstract Background A ‘mortality risk score’ (MS) based on ten prominent mortality-related cytosine-phosphate-guanine (CpG) sites was previously associated with all-cause mortality, but has not been verified externally. We aimed to validate the association of MS mortality and compare three aging biomarkers: telomere length (TL), DNA methylation age (DNAmAge) phenotypic (DNAmPhenoAge) explore whether can serve as a reliable measure biological mortality. Methods Among 534 males aged 55–85...
Abstract Background The difference between an individual's chronological and DNA methylation predicted age (DNAmAge), termed DNAmAge acceleration (DNAmAA), can capture life-long environmental exposures age-related physiological changes reflected in status. Several studies have linked DNAmAA to morbidity mortality, yet its relationship with kidney function has not been assessed. We evaluated the associations seven DNAm aging lifespan predictors (as well as GrimAge components) five traits...
Background Immigrant status and citizenship influence health well-being, yet their associations with DNA methylation (DNAm)-based biomarkers of aging – key predictors healthspan lifespan, also known as epigenetic remain underexplored.
Abstract Background DNA methylation-based predictors of phenotypic traits including leukocyte proportions, smoking activity, biological aging, and circulating levels plasma proteins are widely used as biomarkers in public health research. However, limited racial ethnic diversity research participants is an ongoing issue for epigenetics research, the potential downstream impacts training samples on performance epigenetic remains poorly understood. We examined chronological age (also known...
Abstract Background Health status is closely linked to both healthcare access and utilization. While previous research has identified associations between health DNA methylation-based biomarkers of aging (epigenetic aging), studies exploring these relationships in the context utilization remain limited. To address this gap, we analyzed cross-sectional a representative sample 2,343 U.S. adults from 1999–2000 2001–2002 cycles National Nutrition Examination Survey (NHANES). Our study examined...